Contents - Clinical Cancer Research

Clinical Cancer Research

Contents

October 1, 2008 Vol 14, No 19

CCR Translations Colon Cancer: It’s CIN or CIMP.

Commentary on Cheng et al., p. 6005 Jean-Pierre Issa ........................................................................................................................................................5939

Molecular Pathways Single-Agent and Combination Therapeutic Strategies to Inhibit Hepatocyte Growth Factor/MET Signaling in Cancer. Luca Toschi and Pasi A. Jänne ..................................................................5941 Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia. Michail V. Sitkovsky, Jorgen Kjaergaard, Dmitriy Lukashev, and Akio Ohta .................................................................................................................................................5947

CCR Focus From the Editor. Susan E. Bates ....................................................................................................................5953 Statistical Issues in Translational Cancer Research. Stephen L. George ..............................................5954 Statistical Challenges in Preprocessing in Microarray Experiments in Cancer. Kouros Owzar, William T. Barry, Sin-Ho Jung, Insuk Sohn, and Stephen L. George ...........................................................5959 Validation of Analytic Methods for Biomarkers Used in Drug Development. Cindy H. Chau, Olivier Rixe, Howard McLeod, and William D. Figg .....................................................................................5967 Validation of Biomarker-Based Risk Prediction Models. Jeremy M.G. Taylor, Donna P. Ankerst, and Rebecca R. Andridge .................................................................................................................................5977 The Use of Genomics in Clinical Trial Design. Richard Simon ..............................................................5984

Human Cancer Biology Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer. Jennifer M. Bailey, Benjamin J. Swanson, Tomofumi Hamada, John P. Eggers, Pankaj K. Singh, Thomas Caffery, Michel M. Ouellette, and Michael A. Hollingsworth ...........................................................................................5995 CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer. Yu-Wei Cheng, Hanna Pincas, Manny D. Bacolod, Gunter Schemmann, Sarah F. Giardina, Jianmin Huang, Sandra Barral, Kamran Idrees, Sajid A. Khan, Zhaoshi Zeng, Shoshana Rosenberg, Daniel A. Notterman, Jurg Ott, Philip Paty, and Francis Barany ................................6005 Immunohistochemical Expression of Basic Fibroblast Growth Factor and Fibroblast Growth Factor Receptors 1 and 2 in the Pathogenesis of Lung Cancer. Carmen Behrens, Heather Y. Lin, J. Jack Lee, Maria Gabriela Raso, Waun Ki Hong, Ignacio I. Wistuba, and Reuben Lotan ............................6014 Immunohistochemical and Biogenetic Features of Diffuse-Type Tenosynovial Giant Cell Tumors: The Potential Roles of Cyclin A, P53, and Deletion of 15q in Sarcomatous Transformation. Hsuan-Ying Huang, Robert B. West, Ching-Cherng Tzeng, Matt van de Rijn, Jun-Wen Wang, Shih-Cheng Chou, Wen-Wei Huang, Hock-Liew Eng, Ching-Nan Lin, Shih-Chen Yu, Jing-Mei Wu, Chiu-Chin Lu, and Chien-Feng Li ..................................................................................................6023 Deletions of CDKN2C in Multiple Myeloma: Biological and Clinical Implications. Paola E. Leone, Brian A. Walker, Matthew W. Jenner, Laura Chiecchio, GianPaolo Dagrada, Rebecca K.M. Protheroe, David C. Johnson, Nicholas J. Dickens, Jose Luis Brito, Monica Else, David Gonzalez, Fiona M. Ross, Selina Chen-Kiang, Faith E. Davies, and Gareth J. Morgan ......................6033

www.aacrjournals.org Downloaded from clincancerres.aacrjournals.org on July 9, 2018. © 2008 American Association for Cancer Research.

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators. Hui-Wen Lo, Xinyu Cao, Hu Zhu, and Francis Ali-Osman ..........................................................6042 Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis. Shuji Mikami, Mototsugu Oya, Masayuki Shimoda, Ryuichi Mizuno, Masaru Ishida, Takeo Kosaka, Makio Mukai, Motowo Nakajima, and Yasunori Okada .........................................................6055 Androgen-Regulated and Highly Tumorigenic Human Prostate Cancer Cell Line Established from a Transplantable Primary CWR22 Tumor. Ayush Dagvadorj, Shyh-Han Tan, Zhiyong Liao, Luciane R. Cavalli, Bassem R. Haddad, and Marja T. Nevalainen .....................................................................6062 Effects of Manganese Superoxide Dismutase Silencing on Androgen Receptor Function and Gene Regulation: Implications for Castration-Resistant Prostate Cancer. Nima Sharifi, Elaine M. Hurt, Suneetha B. Thomas, and William L. Farrar ..............................................................................6073 Negative Regulation of the Osteoblast Function in Multiple Myeloma through the Repressor Gene E4BP4 Activated by Malignant Plasma Cells. Franco Silvestris, Paola Cafforio, Monica De Matteo, Nicola Calvani, Maria A. Frassanito, and Franco Dammacco .........................................6081 Epidermal Growth Factor Receptor Mutations in Small Cell Lung Cancer. Akiko Tatematsu, Junichi Shimizu, Yoshiko Murakami, Yoshitsugu Horio, Shigeo Nakamura, Toyoaki Hida, Tetsuya Mitsudomi, and Yasushi Yatabe ................................................................................................................6092 IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and Neck Cancer Progression. Hiroko Hatano, Yasusei Kudo, Ikuko Ogawa, Takaaki Tsunematsu, Akira Kikuchi, Yoshimitsu Abiko, and Takashi Takata ........................................................................................6097

Cancer Therapy: Preclinical Cotreatment with Vorinostat Enhances Activity of MK-0457 (VX-680) against Acute and Chronic Myelogenous Leukemia Cells. Warren Fiskus, Yongchao Wang, Rajeshree Joshi, Rekha Rao, Yonghua Yang, Jianguang Chen, Ravindra Kolhe, Ramesh Balusu, Kelly Eaton, Pearl Lee, Celalettin Ustun, Anand Jillella, Carolyn A. Buser, Stephen Peiper, and Kapil Bhalla ................................6106 An Immunotolerant HER-2/neu Transgenic Mouse Model of Metastatic Breast Cancer. Hong Song, Karineh Shahverdi, David L. Huso, Yuchuan Wang, James J. Fox, Robert F. Hobbs, Barjor Gimi, Kathleen L. Gabrielson, Martin G. Pomper, Benjamin M. Tsui, Zaver Bhujwalla, R. Todd Reilly, and George Sgouros .................................................................................................................6116 Dissociation of Its Opposing Immunologic Effects Is Critical for the Optimization of Antitumor CD8+ T-Cell Responses Induced by Interleukin 21. Sascha Ansén, Marcus O. Butler, Alla Berezovskaya, Andrew P. Murray, Kristen Stevenson, Lee M. Nadler, and Naoto Hirano ....................6125 Multimodality Imaging of IL-18–Binding Protein-Fc Therapy of Experimental Lung Metastasis. Qizhen Cao, Weibo Cai, Gang Niu, Lina He, and Xiaoyuan Chen .........................................6137 Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models of Human Hepatocellular Carcinoma. Hung Huynh, Van Chanh Ngo, Joseph Fargnoli, Mark Ayers, Khee Chee Soo, Heng Nung Koong, Choon Hua Thng, Hock Soo Ong, Alexander Chung, Pierce Chow, Pamela Pollock, Sara Byron, and Evelyn Tran .........................................................................6146 Therapy of Advanced B-Lymphoma Xenografts with a Combination of 90 Y-anti-CD22 IgG (Epratuzumab) and Unlabeled Anti-CD20 IgG (Veltuzumab). M. Jules Mattes, Robert M. Sharkey, Habibe Karacay, Myron S. Czuczman, and David M. Goldenberg ...............................................................6154 Therapeutic IMC-C225 Antibody Inhibits Breast Cancer Cell Invasiveness via Vav2-Dependent Activation of RhoA GTPase. Poonam R. Molli, Liana Adam, and Rakesh Kumar.....................................6161

Downloaded from clincancerres.aacrjournals.org on July 9, 2018. © 2008 American Association for Cancer Research.

Potent Anticarcinoma Activity of the Humanized Anti-CD70 Antibody h1F6 Conjugated to the Tubulin Inhibitor Auristatin via an Uncleavable Linker. Ezogelin Oflazoglu, Ivan J. Stone, Kristine Gordon, Christopher G. Wood, Elizabeth A. Repasky, Iqbal S. Grewal, Che-Leung Law, and Hans-Peter Gerber .....................................................................................................................................6171 Characteristics of Dasatinib- and Imatinib-Resistant Chronic Myelogenous Leukemia Cells. Seiichi Okabe, Tetsuzo Tauchi, and Kazuma Ohyashiki ................................................................................6181 Therapeutic Potential of Replication-Selective Oncolytic Adenoviruses on Cells from Familial and Sporadic Desmoid Tumors. Inge Peerlinck, Saeid Amini-Nik, Robin K. Phillips, Richard Iggo, Nicholas R. Lemoine, Sabine Tejpar, and Georges Vassaux ...................................................6187 Integrin Agonists as Adjuvants in Chemotherapy for Melanoma. Martin A. Schwartz, Kevin McRoberts, Matthew Coyner, Kumari L. Andarawewa, Henry F. Frierson, Jr., John M. Sanders, Stephen Swenson, Frank Markland, Mark R. Conaway, and Dan Theodorescu ..........................................6193 BKM1740, an Acyl-Tyrosine Bisphosphonate Amide Derivative, Inhibits the Bone Metastatic Growth of Human Prostate Cancer Cells by Inducing Apoptosis. Seong II Seo, Lajos Gera, Haiyen E. Zhau, Wei Ping Qian, Shareen Iqbal, Nicole A. Johnson, Shumin Zhang, Majd Zayzafoon, John Stewart, Ruoxiang Wang, Leland W.K. Chung, and Daqing Wu ..........................................................6198 Differentiation of Human Embryonic Stem Cells into Immunostimulatory Dendritic Cells under Feeder-Free Culture Conditions. Zhen Su, Carole Frye, Kyung-Mi Bae, Vicky Kelley, and Johannes Vieweg .......................................................................................................................................6207 N-(2,6-Dimethoxypyridine-3-yl)-9-Methylcarbazole-3-Sulfonamide as a Novel Tubulin Ligand against Human Cancer. Yue-Ming Wang, Lai-Xing Hu, Zhen-Ming Liu, Xue-Fu You, Sheng-Hua Zhang, Jing-Rong Qu, Zhuo-Rong Li, Yan Li, Wei-Jia Kong, Hong-Wei He, Rong-Guang Shao, Liang-Ren Zhang, Zong-Gen Peng, David W. Boykin, and Jian-Dong Jiang .......................................................................................6218 Liposome-Encapsulated Curcumin Suppresses Growth of Head and Neck Squamous Cell Carcinoma In vitro and in Xenografts through the Inhibition of Nuclear Factor ␬B by an AKT-Independent Pathway. Dorothy Wang, Mysore S. Veena, Kerry Stevenson, Christopher Tang, Baran Ho, Jeffrey D. Suh, Victor M. Duarte, Kym F. Faull, Kapil Mehta, Eri S. Srivatsan, and Marilene B. Wang ......................................................................................................................................6228

Imaging, Diagnosis, Prognosis Identification of GRP75 as an Independent Favorable Prognostic Marker of Neuroblastoma by a Proteomics Analysis. Wen-Ming Hsu, Hsinyu Lee, Hsueh-Fen Juan, Yu-Yin Shih, Bo-Jeng Wang, Chien-Yuan Pan, Yung-Ming Jeng, Hsiu-Hao Chang, Meng-Yao Lu, Kai-Hsin Lin, Hong-Shiee Lai, Wei-Jao Chen, Yeou-Guang Tsay, Yung-Feng Liao, and Fon-Jou Hsieh ........................................................6237 Salivary Proteomics for Oral Cancer Biomarker Discovery. Shen Hu, Martha Arellano, Pinmanee Boontheung, Jianghua Wang, Hui Zhou, Jiang Jiang, David Elashoff, Roger Wei, Joseph A. Loo, and David T. Wong .........................................................................................................................6246 Shedding of Distinct Cryptic Collagen Epitope (HU177) in Sera of Melanoma Patients. Bruce Ng, Jan Zakrzewski, Melanie Warycha, Paul J. Christos, Dean F. Bajorin, Richard L. Shapiro, Russell S. Berman, Anna C. Pavlick, David Polsky, Madhu Mazumdar, Anthony Montgomery, Leonard Liebes, Peter C. Brooks, and Iman Osman ......................................................................................6253 Transesophageal Endoscopic Ultrasound with Fine Needle Aspiration in the Preoperative Staging of Malignant Pleural Mesothelioma. Kurt G. Tournoy, Sjaak A. Burgers, Jouke T. Annema, Frank Vermassen, Marleen Praet, Marianne Smits, Houke M. Klomp, Jan P. van Meerbeeck, and Paul Baas ...................................................................................................................................................6259

www.aacrjournals.org Downloaded from clincancerres.aacrjournals.org on July 9, 2018. © 2008 American Association for Cancer Research.

Reprimo as a Potential Biomarker for Early Detection in Gastric Cancer. Carolina Bernal, Francisco Aguayo, Cynthia Villarroel, Macarena Vargas, Ignacio Díaz, Francisco J. Ossandon, Eudocia Santibáñez, Mariana Palma, Edmundo Aravena, Carlos Barrientos, and Alejandro H. Corvalan ..............................................................................................................................6264

Cancer Therapy: Clinical A Phase I-II Study of Docetaxel and Atrasentan in Men with Castration-Resistant Metastatic Prostate Cancer. Andrew J. Armstrong, Patricia Creel, James Turnbull, Cassandra Moore, Tracy A. Jaffe, Sherri Haley, William Petros, Sarah Yenser, Jon P. Gockerman, Darryl Sleep, Herbert Hurwitz, and Daniel J. George .................................................................................................................6270 A Phase I-II Study of Combined Blockade of the ErbB Receptor Network with Trastuzumab and Gefitinib in Patients with HER2 (ErbB2)-Overexpressing Metastatic Breast Cancer. Carlos L. Arteaga, Anne O’Neill, Stacy L. Moulder, Michael Pins, Joseph A. Sparano, George W. Sledge, and Nancy E. Davidson ....................................................................................................6277 Single Nucleotide Polymorphisms, Apoptosis, and the Development of Severe Late Adverse Effects After Radiotherapy. David Azria, Mahmut Ozsahin, Andrew Kramar, Sheila Peters, David P. Atencio, Nigel E.A. Crompton, Françoise Mornex, André Pèlegrin, Jean-Bernard Dubois, René-Olivier Mirimanoff, and Barry S. Rosenstein ........................................................................................6284 Zoledronic Acid Markedly Improves Bone Mineral Density for Patients with Monoclonal Gammopathy of Undetermined Significance and Bone Loss. James R. Berenson, Ori Yellin, Ralph V. Boccia, Marshall Flam, Siu-Fun Wong, Olcay Batuman, Mehdi M. Moezi, Donald Woytowitz, Herbert Duvivier, Youram Nassir, and Regina A. Swift .................................................................................6289 Phase I Study of Epigenetic Modulation with 5-Azacytidine and Valproic Acid in Patients with Advanced Cancers. Fadi Braiteh, Andres O. Soriano, Guillermo Garcia-Manero, David Hong, Marcella M. Johnson, Leandro De Padua Silva, Hui Yang, Stefanie Alexander, Johannes Wolff, and Razelle Kurzrock .................................................................................................................................................6296 Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer. Johann S. de Bono, Howard I. Scher, R. Bruce Montgomery, Christopher Parker, M. Craig Miller, Henk Tissing, Gerald V. Doyle, Leon W.W.M. Terstappen, Kenneth J. Pienta, and Derek Raghavan ................................................................................................................6302 A Phase I Trial of Pemetrexed Plus Gemcitabine Given Biweekly with B-Vitamin Support in Solid Tumor Malignancies or Advanced Epithelial Ovarian Cancer. Martee L. Hensley, Joseph Larkin, Matthew Fury, Scott Gerst, D. Fritz Tai, Paul Sabbatini, Jason Konner, Mauro Orlando, Tiana L. Goss, and Carol A. Aghajanian ..........................................................................................................6310 Fluorescence In situ Hybridization Subgroup Analysis of TRIBUTE, a Phase III Trial of Erlotinib Plus Carboplatin and Paclitaxel in Non–Small Cell Lung Cancer. Fred R. Hirsch, Marileila Varella-Garcia, Rafal Dziadziuszko, Yun Xiao, Sujatha Gajapathy, Margaret Skokan, Ming Lin, Vincent O’Neill, and Paul A. Bunn, Jr. .................................................................................................6317 Phase I Trial of Erlotinib Combined with Cisplatin and Radiotherapy for Patients with Locally Advanced Cervical Squamous Cell Cancer. Angelica Nogueira-Rodrigues, Cláudio C. do Carmo, Célia Viegas, Felipe Erlich, Cláudia Camisão, Karina Fontão, Roberta Lima, Daniel Herchenhorn, Renato G. Martins, Giulliana M. Moralez, Isabele A. Small, and Carlos G. Ferreira ..........................................6324 Letrozole is Superior to Anastrozole in Suppressing Breast Cancer Tissue and Plasma Estrogen Levels. Jürgen Geisler, Hilgegunn Helle, Dagfinn Ekse, Nhat K. Duong, Dean B. Evans, Yngve Nordbø, Turid Aas, and Per E. Lønning .........................................................................6330

Downloaded from clincancerres.aacrjournals.org on July 9, 2018. © 2008 American Association for Cancer Research.

Prevention of Anastrozole-Induced Bone Loss with Monthly Oral Ibandronate during Adjuvant Aromatase Inhibitor Therapy for Breast Cancer. James E. Lester, David Dodwell, Omprakash P. Purohit, Sandra A. Gutcher, Susan P. Ellis, Ruth Thorpe, Janet M. Horsman, Janet E. Brown, Rosemary A. Hannon, and Robert E. Coleman ........................................................................6336

Cancer Prevention and Susceptibility CASP3 Polymorphisms and Risk of Squamous Cell Carcinoma of the Head and Neck. Kexin Chen, Hui Zhao, Zhibin Hu, Li-E Wang, Wei Zhang, Erich M. Sturgis, and Qingyi Wei ..................6343

About the Cover

Immunofluorescent image showing localization of phospho-epidermal growth factor receptor (EGFR, green) and F-actin (red) in MDA-MB231 breast cancer cells stimulated with epidermal growth factor for 30 minutes. In stimulated cells, EGFR undergoes phosphorylation at tyrosine 1086 and the activated EGFR localizes to the newly formed membrane ruffles, important for cancer cell motility and invasion, around the cells rich in F-actin. Colocalization of phospho-EGFR (green) with F-actin is seen in yellow. For further details, please see Molli and co-workers on page 6161 in this issue.

www.aacrjournals.org Downloaded from clincancerres.aacrjournals.org on July 9, 2018. © 2008 American Association for Cancer Research.

14 (19) Clin Cancer Res 2008;14:5939-6349.

Updated version

E-mail alerts Reprints and Subscriptions Permissions

Access the most recent version of this article at: http://clincancerres.aacrjournals.org/content/14/19

Sign up to receive free email-alerts related to this article or journal. To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department at [email protected]. To request permission to re-use all or part of this article, use this link http://clincancerres.aacrjournals.org/content/14/19. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC) Rightslink site.

Downloaded from clincancerres.aacrjournals.org on July 9, 2018. © 2008 American Association for Cancer Research.