[ Product Guide 2011] Sales Offices:
Austria 43 1 877 18 07
Japan 81 3 3471 7191
Australia 61 2 9933 1777
Korea 82 2 6300 4800
Belgium and Luxembourg 32 2 726 1000
Mexico 52 55 52 00 1860
Brazil 55 11 4134 3788
The Netherlands 31 76 508 7200
Canada 1 800 252 4752
Norway 47 6 384 6050
China 86 21 6156 2666
Poland 48 22 833 4400
Czech Republic 420 2 617 11384
Puerto Rico 1 787 747 8445
Denmark 45 46 59 8080
Russia/CIS 495 727 4490 / 290 9737
Finland 358 9 5659 6288
Singapore 65 6593 7100
Whether you work in pharmaceuticals, biopharmaceuticals, environmental,
France 33 1 30 48 72 00
Spain 34 93 600 9300
food testing, clinical, or beyond, with Waters application focused solutions,
Germany 49 6196 400 600
Sweden 46 8 555 115 00
you can be assured that whenever a new analytical challenge arises,
Hong Kong 852 2964 1800
Switzerland 41 56 676 7000
Waters will have the technology and expertise to help you conquer it.
Hungary 36 1 350 5086
Taiwan 886 2 2501 9928
These solutions provide a comprehensive approach to address analytical
India 91 80 2837 1900
UK 44 208 238 6100
lab needs that include instrumentation, columns and sample prep,
Ireland 353 1 448 1500
US 1 800 252 4752
software, and support services.
Italy 39 02 265 0983
Designed by scientists for scientists, Waters solutions remove the guesswork in choosing the best way to achieve your application’s goals.
ACQUITY, ACQUITY UPLC, Alliance, Atlantis, AutoPurification, AutoSpec, Connections INSIGHT, ESCi, GCT Premier, nanoACQUITY UPLC, NuGenesis, Oasis, PAT ROL, Pico•Tag, Sep-Pak, StepWave, Symbiosis, Symmetry, SYNAPT, Triwave, UPLC, Waters, Waters Quality Parts, and Xevo are registered trademarks of Waters Corporation. AccQ•Tag, Auto•Blend, Auto•Blend Plus, AutoSpec, BiopharmaLynx, BioSuite, Breeze, ChromaLynx, CSH, DisQuE, DriftScope, E High Definition Proteomics, Empower, Engineered Simplicity, Expression, FractionLynx, HDI, HDMS, High Definition MS, i-FIT, IntelliStart, MALDI SYNAPT, MarkerLynx, MassFragment, MassLynx, MassPREP, MetaboLynx, OBD, OpenLynx, OpenQuan, Ostro, PoraPak, POSI+IV E, ProteinLynx Global SERV ER, QuanOptimize, Quattro micro, Quattro Premier, RADAR, Real-TIME LC, ScanWave, SDMS Vision Publisher, Sirocco, SunFire, TargetLynx, T RIZAIC nanoTile, T RIZAIC UPLC, UNIFI, UPSFC, VanGuard, Viridis, XBridge, and XSelect, and T he Science of W hat’s Possible, are trademarks of Waters Corporation. S-Matrix and Fusion are trademarks of S-Matrix Corporation. All other trademarks are the property of their respective owners. ©2011 Waters Corporation. Printed in the U.S.A. March 2011 720002048EN LL-CP
Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com
[ Product Guide 2011] Sales Offices:
Austria 43 1 877 18 07
Japan 81 3 3471 7191
Australia 61 2 9933 1777
Korea 82 2 6300 4800
Belgium and Luxembourg 32 2 726 1000
Mexico 52 55 52 00 1860
Brazil 55 11 4134 3788
The Netherlands 31 76 508 7200
Canada 1 800 252 4752
Norway 47 6 384 6050
China 86 21 6156 2666
Poland 48 22 833 4400
Czech Republic 420 2 617 11384
Puerto Rico 1 787 747 8445
Denmark 45 46 59 8080
Russia/CIS 495 727 4490 / 290 9737
Finland 358 9 5659 6288
Singapore 65 6593 7100
Whether you work in pharmaceuticals, biopharmaceuticals, environmental,
France 33 1 30 48 72 00
Spain 34 93 600 9300
food testing, clinical, or beyond, with Waters application focused solutions,
Germany 49 6196 400 600
Sweden 46 8 555 115 00
you can be assured that whenever a new analytical challenge arises,
Hong Kong 852 2964 1800
Switzerland 41 56 676 7000
Waters will have the technology and expertise to help you conquer it.
Hungary 36 1 350 5086
Taiwan 886 2 2501 9928
These solutions provide a comprehensive approach to address analytical
India 91 80 2837 1900
UK 44 208 238 6100
lab needs that include instrumentation, columns and sample prep,
Ireland 353 1 448 1500
US 1 800 252 4752
software, and support services.
Italy 39 02 265 0983
Designed by scientists for scientists, Waters solutions remove the guesswork in choosing the best way to achieve your application’s goals.
ACQUITY, ACQUITY UPLC, Alliance, Atlantis, AutoPurification, AutoSpec, Connections INSIGHT, ESCi, GCT Premier, nanoACQUITY UPLC, NuGenesis, Oasis, PAT ROL, Pico•Tag, Sep-Pak, StepWave, Symbiosis, Symmetry, SYNAPT, Triwave, UPLC, Waters, Waters Quality Parts, and Xevo are registered trademarks of Waters Corporation. AccQ•Tag, Auto•Blend, Auto•Blend Plus, AutoSpec, BiopharmaLynx, BioSuite, Breeze, ChromaLynx, CSH, DisQuE, DriftScope, E High Definition Proteomics, Empower, Engineered Simplicity, Expression, FractionLynx, HDI, HDMS, High Definition MS, i-FIT, IntelliStart, MALDI SYNAPT, MarkerLynx, MassFragment, MassLynx, MassPREP, MetaboLynx, OBD, OpenLynx, OpenQuan, Ostro, PoraPak, POSI+IV E, ProteinLynx Global SERV ER, QuanOptimize, Quattro micro, Quattro Premier, RADAR, Real-TIME LC, ScanWave, SDMS Vision Publisher, Sirocco, SunFire, TargetLynx, T RIZAIC nanoTile, T RIZAIC UPLC, UNIFI, UPSFC, VanGuard, Viridis, XBridge, and XSelect, and T he Science of W hat’s Possible, are trademarks of Waters Corporation. S-Matrix and Fusion are trademarks of S-Matrix Corporation. All other trademarks are the property of their respective owners. ©2011 Waters Corporation. Printed in the U.S.A. March 2011 720002048EN LL-CP
Waters Corporation 34 Maple Street Milford, MA 01757 U.S.A. T: 508 478 2000 F: 508 872 1990 www.waters.com
Food Profiling
Food QC and Nutritional Testing
Food Safety
■■
Detect adulteration
■■
Raw material
■■
■■
Assure authenticity
■■
Consistency
■■
■■
Confirm origin
■■
In-process monitoring
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Final product quality
■■
Mycotoxins
Verifying composition and label claims
■■
Marine biotoxins
■■
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Amino acid analysis in food and feed
■■
Pesticides Veterinary drug residues
Forensics
Pharmaceutical
Polymers
Proteomics
Tissue Imaging
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Drugs of abuse
■■
ADME screening
■■
Polymer additives
■■
Characterization
■■
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Toxicology
■■
Bioanalysis
■■
Starch
■■
Quantification
■■
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Bioequivalence
■■
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Biomarker validation
■■
Identification
■■
Processing contaminants
■■
Dissolution testing
■■
Forced degradation
■■
Impurity profiling
■■
Manufacturing
■■
QA/QC
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Lipidomics
■■
Metabolomics
■■
Method development
■■
Method validation
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Natural products
■■
Molecular weight distributions
■■
Drug/metabolite distributions
Bioseparations/ interactions
Metabolite identification
■■
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53
Compound library maintenance
Biomarker discovery
Traditional medicine analysis Open access
54
Featured Systems
6 UPLC 10
UPLC for Process Development and Manufacturing
12
Nanoscale UPLC
14
upsfc
16 HPLC 18
HPLC and SFC Purification
20
sfe
22
Quantitative and Qualitative UPLC/MS
24
Quantitative UPLC/MS/MS
[ contents]
3
26 Exact Mass UPLC MS/MS 28 Exact Mass UPLC/MALDI MS/MS 30
UPLC/MALDI IMS-MS
32
Universal Ionization Architecture
34 Exact Mass GC/MS 36
Quantitative GC/MS AND GC/MS/MS
38
HPLC and SFC Column Solutions
40
UPLC Column Solutions
42
Bioseparations and Analyses Solutions
44
Sample Preparation Solutions
46
Laboratory Informatics Solutions
48
Global Services
50 Waters Centers of Innovation Program 52
Application Solutions
1
Customer Succ ess is Our Mission Waters creates business advantages for laboratory dependent organizations by delivering practical and sustainable scientific innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide. Bringing keen understanding and deep experience to those responsible for laboratory infrastructure and performance, Waters helps customers make profound discoveries, optimize lab operations, deliver product performance, and ensure regulatory compliance. Pioneering a connected portfolio of separation and analytical science, laboratory informatics, and mass spectrometry, Waters’ technology breakthroughs and laboratory solutions provide an enduring platform for customer success.
2
[ featu red syst ems ] Waters systems combine the latest generation of instrumentation, software, consumables, and columns, and are designed to streamline your specific laboratory workflow. Our solutions help analysts satisfy compliance regulations, increase laboratory productivity, and make the best decisions possible.
Biopharmaceutical System Solution with UNIFI.
3
[ Featu red syst ems ]
Biopharmaceutical System Solution with UNIFI™ integrates robust UPLC®/MS
ACQUITY UPLC H-Class Method Development System automates
characterization technology with UNIFI
chromatographic method development
Scientific Information System. UNIFI
according to Quality-by-Design (QbD)
is an industry first comprehensive
guidelines to produce robust, fit-for-
software solution that uniquely unites
purpose methods in dramatically less
all aspects of biotherapeutic analyses
time than traditional processes. The
and workflows, enabling organizations
superior performance of the system
to apply high-resolution analytics across
stems from the power and integration
the development process continuum.
of four class-leading components:
This application-focused platform,
ACQUITY UPLC H-Class; Fusion Method
featuring ACQUITY UPLC H-Class Bio
Development™ Software; Empower™ 3
®
and Xevo G2 Tof technologies, captures
Chromatography Data Software;
complex mass spectrometry and
and Waters ® Method Development
chromatography data, in conjunction
Chemistry kits.
®
with next-generation bioinformatics and GxP data management capabilities.
PATROL UPLC Laboratory Analyzer System introduces proven UPLC Technology to reaction monitoring and optimization experiments. This system integrates sample prep and Real-TIME LC™ analysis in an automated analyzer providing fast and accurate quantitative results to define a process method.
4
ACQUITY UPSFC™ System is the world’s
UPLC with On-Line SPE Technology
first UPLC-based system for SFC. This
streamlines the analysis of drinking water
game-changing UPSFC™ solution enables
samples by providing analyte extraction,
you to confidently conduct normal phase
clean-up, concentration, separation, and
chromatographic separations – including
detection in one turn-key solution.
chiral and achiral applications – using carbon dioxide as the main mobile phase.
Xevo G2 Tof technology offers the most
Now you can minimize harmful waste while
sensitive, exact mass quantitative and
gaining superior selectivity, resolution,
qualitative performance of any benchtop
and speed.
MS system for scientists who need to confidently identify and quantify unknown
ACQUITY UPLC H-Class Bio System
compounds in complex samples.
delivers the benefits of UPLC’s resolution, sensitivity, and throughput in a quaternary
Waters has developed the MassTrak™
system purpose-built for the analysis
range of integrated system solutions to
of proteins, peptides, nucleic acids, and
meet the needs of clinical laboratories,
glycans. Featuring Auto •Blend Plus™
transplant hospitals, and reference
Technology, this is the ideal system for
laboratories. Today we offer complete
the separation of complex biomolecules
solutions, reliable results, and unparalleled
that require multiple chromatographic
support in the fields of therapeutic
techniques for complete characterization,
drug monitoring, metabolic disease,
including reversed phase (RP), ion exchange
endocrinology, and toxicology.
(IEX), size exclusion (SEC), or hydrophilic interaction (HILIC).
5
[ U Plc ]
Access the productivity and
Applications
chromatographic performance of
■■
UPLC with the familiarity of HPLC
HPLC and UPLC analyses with easy method transferability
using the Waters ACQUITY UPLC
■■
Routine analysis
H-Class System.
■■
Method development
■■
Laboratories can now achieve UPLC results with a system that combines the flexibility of ternary or quaternary solvent blending with the simplicity of flow-through
Key Technologies ■■
ACQUITY UPLC H-Class System
■■
ACQUITY UPLC H-Class Bio System
■■
needle injections. You can even continue running your existing
■■
HPLC methods with this forward looking platform and seamlessly
■■
transition to UPLC separations
■■
when you’re ready. ■■
■■
■■ ■■
■■ ■■
■■
6
Quality assurance and quality control
ACQUITY UPLC H-Class Method Development System ACQUITY UPLC H-Class System with 2D technology Quaternary Solvent Management Auto •Blend™ and Auto •Blend Plus™ Technology Photodiode Array, Tunable UV, Fluorescence, and Evaporative Light Scattering UPLC detectors ACQUITY® single and tandem quadrupole detectors Empower™ or MassLynx™ software Local Console Controller for handheld remote operation Connections INSIGHT® Remote Services ACQUITY UPLC BEH, CSH, HSS, VanGuard™ columns and chemistries ACQUITY UPLC Method Development and Method Transfer kits
Join the ACQUITY UPLC community at www.waters.com/MYUPLC
ACQUITY UPLC H-Class System.
7
[ U PLC ]
The ACQUITY UPLC System
Applications
is the original UPLC system
■■
Qualitative and quantitative analyses
introduced over six years ago.
■■
Analysis of samples in complex matrices
■■
Trace analysis
■■
High-throughput and open access runs
■■
Method development
■■
Clinical and diagnostic
This UPLC system allows analytical chemists to reach far beyond conventional LC separations and proves itself to be an asset to laboratories around the
Key Technologies
world. UPLC Technology sets
■■
new standards in resolution,
■■
sensitivity, and throughput
ACQUITY UPLC System ACQUITY UPLC System with 2D technology
by being the first holistically-
■■
UPLC Open Architecture System
designed system that maximizes
■■
UPLC with On-Line SPE Technology
the performance of sub-2-μm
■■
Binary Solvent Management
particles. It has fueled more than
■■
500 peer reviewed papers, helps
■■
laboratories conserve resources, and serves the needs of regulatory agencies around the globe. ACQUITY UPLC simultaneously
■■
makes your laboratory more sustainable and more efficient.
■■ ■■
■■ ■■
■■
8
Superior inlet to mass spectrometry independent of vendor ACQUITY UPLC Photodiode Array, Tunable UV, Fluorescence, and Evaporative Light Scattering UPLC detectors ACQUITY UPLC single and tandem quadrupole mass detectors Empower or MassLynx software Local Console Controller for handheld remote operation Connections INSIGHT Remote Services ACQUITY UPLC BEH, CSH, HSS, and VanGuard columns and chemistries ACQUITY UPLC Aflatoxin and Perfluorinated Compound kits
“ Waters introduced the technique onto the market under the name UPLC in 2004, using columns with 1.7 μm diameter spherical particles and a pumping capability of up to 15,000 psi. UPLC allowed industrial, commercial, and research laboratories to take full advantage of improved separation, and thus 2004 marked a new era of great steps forward in productivity, quality, sample throughput, and cost reduction.”
Baltussen EA, Noij THM. NOTOX BV European Pharmaceutical Contractor. 2009 Jun; 36-40.
ACQUITY UPLC System with Sample Organizer.
9
[ U PLC FOR P ROCESS DEV ELOPMENT and MANUFACTURING ]
Waters’ new PATROL UPLC
Applications
Laboratory Analyzer System is
■■
designed for reaction monitoring and optimization experiments.
■■
It integrates sample prep and
Real-TIME LC analysis in manufacturing processes Quantitative measurement of Critical Quality Attributes
Real-TIME LC analysis in an
■■
Process development
automated analyzer providing fast,
■■
Cleaning validation
and accurate quantitative results
■■
Process reaction monitoring
to define a process method.
■■
Waters PATROL UPLC Process
Key Technologies
Analyzer System is a real-time
■■
Process Analytical Technology
Development reaction optimization and characterization PATROL UPLC Laboratory Analyzer System
(PAT) system that detects and
■■
PATROL UPLC Process Analyzer System
quantifies complex multiple
■■
Online and atline configurations
component manufacturing samples
■■
Empower Software
and final product directly on the
■■
NuGenesis ® SDMS Information Platform
production floor.
■■
ACQUITY UPLC Columns
■■
Connections INSIGHT Remote Services
The validated methods transferred from the PATROL UPLC Laboratory Analyzer to the PATROL UPLC Process Analyzer ensure regulatory compliance on the manufacturing floor as well as results that improve operational efficiency, deliver quantifiable ROI, and increase profits.
10
Learn more at www.waters.com/PATROL
“ …A fast LC technique like Waters’ UltraPerformance LC® (UPLC) may be time-equivalent to techniques like near-infrared, UV, and Raman, providing what amounts to real-time analysis … Data from [ PATROL] UPLC experiments is impressive. For real-time analysis, UPLC does not demand a trade-off among resolution, sensitivity, and speed. UPLC routinely separates complex solutions in less than 30 seconds.”
DePalma A. Writer, Editor, and Consultant Genetic Engineering & Biotechnology News. 2008 Jun; 28(11).
PATROL UPLC System.
11
[ NANOSCALE U PLC ]
The nanoACQUITY UPLC® System
Applications
has been designed for microbore
■■
Biomarker discovery
to nanoscale separations to
■■
Protein identification
attain the highest sensitivity and
■■
Protein characterization
chromatographic resolution for
■■
Metabolite identification
UPLC and UPLC/MS. It allows scientists to achieve separations at nanoflow rates without flow-
Key Technologies ■■ ■■
splitting, offering significant improvements in robustness,
■■
reproducibility, and simplicity of operation over conventional
■■
nanoflow separations technologies.
nanoACQUITY UPLC System nanoACQUITY UPLC System with 2D Technology nanoACQUITY System with HDX Technology Atlantis ®, Symmetry ®, and BEH chemistries
Also available with 2D capabilities
■■
Waters MS and HDMS™ technologies
for increased peak capacity and
■■
Superior mass spectrometry inlet
dynamic range.
■■
nanoACQUITY UPLC Columns
■■
TRIZAIC UPLC nanoTile™
Optional TRIZAIC™ UPLC Technology provides UPLC performance in a userfriendly platform for sample limited separations.
12
“ T he nanoACQUITY [UPLC] System is a high-pressure nanoflow pump that can deliver flow rates down to hundreds of nanoliters per minute, and this is important because of the reproducibility requirements for the protein expression profiling. Another innovation that Waters has come forth with is small particle LC packing that delivers superior peptide separation. That truly is a step forward in our ability to see low-level proteins in this complex mixture.”
Cavey G. Special Program Investigator, Van Andel Institute
nanoACQUITY UPLC System.
13
[ u psfc ]
Experience analytical supercritical
Applications
fluid chromatography (SFC)
■■
Normal phase applications
like never before with Waters new
■■
Achiral analysis
ACQUITY UPSFC System. This
■■
Chiral analysis
normal phase chromatagraphic
■■
Pharmaceutical
solution uses CO2 as the main
■■
Fine chemicals
mobile phase, reducing solvent and waste. Now you can run normal phase chiral and achiral
Key Technologies ■■ ■■
applications using superior performance with this holistically
■■
designed, UPLC-based SFC
■■
system integrated with Waters Viridis™ SFC Columns.
■■ ■■
■■
14
ACQUITY UPSFC System ACQUITY UPSFC Binary Solvent Manager ACQUITY UPSFC PDA Detector Single and tandem quadrupole mass detectors Empower or MassLynx software Connections INSIGHT Remote Services Viridis SFC Column chemistries
Learn more at www.waters.com/UPSFC
ACQUITY UPSFC System.
15
[ H PLC ]
Whatever your application,
Applications
the Alliance HPLC and
■■
Fine and specialty chemicals
Breeze™ 2 HPLC systems offer
■■
Food safety analysis
you proven solutions for all
■■
Environmental analysis
of your HPLC requirements –
■■
Quality control
today and in the future. These
■■
Clinical/diagnostics
systems are synonymous
■■
Pharmaceutical
®
with dependable, routine performance, and versatility.
Key Technologies ■■
Alliance HPLC and HPLC/MS systems
■■
Alliance HPLC Dissolution System
■■
Alliance HPLC Bioseparations System
■■
BioSuite™ Bioseparation Columns
■■
Breeze 2 HPLC systems
■■
Empower or MassLynx software
■■
■■
■■
16
UV/Visible, Photodiode Array, Evaporative Light Scattering, Multi-λ Fluorescence, Refractive Index, Electrochemical, and Conductivity HPLC detectors Alliance HPLC System with the 3100 Mass Detector
Learn more at www.waters.com/HPLC
“ …[Alliance HPLC] methods used in the present paper are reliable, easy and fast to perform…The large number of patients tested here demonstrates that the UV method has sufficient selectivity and accuracy for the analysis of patients’ samples… Moreover, one major benefit of HPLC–UV is its availability in hospitals and small laboratories…”
Awidi A, et al. Professor of Medicine, Hematology and Oncology Jordan University Leuk Res. 2009 Sep 8.
Alliance HPLC System with the 3100 Mass Detector.
17
[ H PLC and SFC Purification ]
Waters’ robust purification
Applications
solutions are uniquely flexible
■■
Compound isolation and purification
and scalable, from high-throughput
■■
UV- or mass-directed fraction collection
fraction collection of hundreds
■■
Milligram to kilogram amounts
of samples, to simple systems
■■
Pharmaceutical
for purifying just a handful of
■■
Biopharmaceutical
samples a day. Offering MS and
■■
UV capabilities with our HPLC and
Natural products and traditional Chinese herbal medicines
supercritical fluid chromatography
Key Technologies
(SFC) innovations, a full range
■■
of Optimum Bed Density (OBD™)
AutoPurification™ LC and LC/MS systems
and Viridis SFC Columns, and
■■
SFC Prep 100 UV and MS systems
world-class service and support,
■■
Empower or MassLynx software
Waters is your single-vendor
■■
FractionLynx™ Application Manager
solution that encompasses the
■■
entire purification range. ■■
18
OpenLynx™ Open Access Application Manager 2545 Binary or 2535/2545/2555 Quaternary gradient modules
■■
Fraction Collector III
■■
Optimum Bed Density (OBD) Columns
■■
Viridis SFC Column chemistries
www.waters.com/PREP
AutoPurification System with the 3100 Mass Detector.
19
[ sfe ]
Waters’ Supercritical Fluid
Applications
Extraction (SFE) systems extract
■■
chemical compounds using supercritical CO2 in place of an
■■
organic solvent. The result is an extract with little or no residual
■■
solvent, superior purity and
■■
yield, and lower operating
Extraction and fractionation of edible fats and oils Separation of tocopherols and other antioxidants Detoxification of shellfish Production of flavors, spice extracts, herbs, dietary supplements
costs compared to traditional
■■
hydrocarbon-based solvent
Precision parts cleaning
■■
extraction systems.
Desolvation within tablets
■■
SFE is capable of extracting compounds from solid matrices
Key Technologies
to isolate the analyte of
■■
interest, without altering the
■■
taste, aroma, or chemical composition of your product.
■■
■■
20
Steroids, polymer/monomer separation High pressure CO2 pump High pressure (10,000 PSI) Finger-tight vessel Automated Back Pressure Regulator (ABPR) Custom software for easyto-use instrument control and data management
The biggest advantage of SFE is that you can extract your compound with little or no residual solvent, keeping your product safe, uncontaminated, and natural.
SFE 1000 System.
21
[ QUANT ITATIV E and QUALITATIV E U PLC /MS ]
For scientists who need to
Applications
confidently identify and quantify
■■
Peptide mapping experiments
unknown compounds in complex
■■
Intact protein analysis
samples, Xevo G2 Tof with UPLC/MS E
■■
Metabolite identification
and QuanTof Technology offers
■■
Discovery DMPK quantitation
exceptional levels of selectivity,
■■
Food safety screening
in-spectrum dynamic range, speed
■■
Environmental monitoring
of analysis, quantitative accuracy,
■■
Exact mass open access analysis
and exact mass performance
■■
Toxicology screening
simultaneously at unparalleled levels of sensitivity.
Key Technologies ■■
Waters’ sample preparation solutions
■■
ACQUITY UPLC Columns
■■
■■
QuanTof Technology
■■
UPLC/MS E
■■
■■
■■
Waters’ Universal Ion Source Architecture Atmospheric Solids Analysis Probe (ASAP) Atmospheric Pressure GC (APGC) source
■■
IntelliStart™ Technology
■■
MassLynx Software
■■
■■
22
MassPrep™ Peptide and Protein Standards
ChromaLynx™, MarkerLynx™, BiopharmaLynx™, MetaboLynx™ XS, TargetLynx™, and POSI±IVE™ application managers Biopharmaceutical System Solution with UNIFI
“ … the capacity for conducting preliminary metabolite identification experiments has increased by almost an order of magnitude, and the turnaround time for metabolism data has been shortened to the point where the information has a much greater impact on decision making.”
Tiller PR, et al. Drug Metabolism, Merck Research Laboratories Rapid Commun. Mass Spectrom. 2008 Apr; 22(7):1053-61.
ACQUITY UPLC H-Class System with the Xevo G2 Tof.
23
[ Quant itativ e U PLC /MS/MS ]
Xevo TQ and Xevo TQ-S are the
Applications
analytical tools of choice for your
■■
most challenging quantitative UPLC/MS/MS applications,
■■
delivering the ultimate in versatility
Environmental and food safety analysis Pharmaceutical discovery and development
for a wide variety of applications –
■■
Quantitative bioanalysis
both quantitative and qualitative.
■■
Clinical assays
■■
Metabolite screening
Xevo TQ-S features a revolutionary new off-axis ion-source technology, known as StepWave™. Quantify and confirm trace components at the lowest possible levels in the most complex samples. Both Xevo TQ
Key Technologies ■■
ACQUITY UPLC System
■■
ACQUITY Columns
■■
■■
and Xevo TQ-S offer ScanWave™ Technology for rapid MRM
■■
acquisition for targeted
■■
quantification – and RADAR™ – for collection of highly specific
■■
quantitative data for target compounds and visualization of all other components in sample matrices. With Xevo TQ and Xevo TQ-S, you will develop methods that bring drugs to market faster, identify a broader array of food contaminants, and report reliable forensic data with complete confidence.
24
■■ ■■
MassPrep Peptide and Protein Standards TQ Detector, Xevo TQ, and Xevo TQ-S IntelliStart Technology MassLynx or Empower software (TQ Detector only) TargetLynx, QuanOptimize™, OpenQuan™, ChromaLynx, and MetaboLynx XS application managers NuGenesis SDMS Atmospheric GC ion source option for fast swapping between LC and GC applications (Xevo TQ and TQ-S only)
“ A fast and simple UPLC/MS/MS method involving… very fast switching of the polarity of ionization allows simultaneous determination of compounds that are amenable to analysis as positive and negative ions. Furthermore, the rapid voltage stabilization in the electronics and detection system… following switches of polarity, ensured that very short inter-channel delays could be used minimizing losses in response. The high resolution capacity of the UPLC method combined with the extremely short analysis times… offers significant benefit for this type of analysis…”
Leandro C.C., et al. Central Science Laboratory, University of York J Chromatogr A. 2007 Mar 16;1144(2):161-9.
ACQUITY UPLC System with the Xevo TQ-S.
25
[ EXACT MASS U PLC MS/MS ]
Xevo G2 QTof with UPLC/MS E
Applications
and QuanTof Technology offers
■■
Biopharmaceutical characterization
unparalleled sensitivity with
■■
Metabolite profiling
exceptional levels of selectivity,
■■
Forensic toxicology
in-spectrum dynamic range, speed
■■
Food analysis
of analysis, quantitative accuracy,
■■
Environmental research
and exact mass performance
■■
Chemical industry research
simultaneously, for any UPLC/MS,
■■
Proteomics studies
MS or MS/MS experiment. E
Key Technologies
Xevo G2 QTof delivers UPLC/MS E –
■■
Waters’ sample preparation solutions
a simple, patented method of data
■■
ACQUITY UPLC
acquisition that comprehensively
■■
ACQUITY UPLC Columns
catalogs complex samples in a
■■
QuanTof Technology
single analysis. It also provides
■■
UPLC/MS E
UPLC/FastDDA: rapid, automated,
■■
intelligent exact-mass MS/MS for full structural characterization and isobaric labeling quantitative
■■
■■
proteomics experiments.
Atmospheric Solids Analysis Probe (ASAP) Atmospheric Pressure GC (APGC) source
■■
IntelliStart Technology
■■
MassLynx Software
■■
26
Waters’ Universal Ion Source Architecture
ProteinLynx Global Server™, POSI+IVE, MarkerLynx, TargetLynx, BiopharmaLynx, ChromaLynx, and MetaboLynx application managers
See the Xevo G2 QTof video at www.waters.com/XEVO
“ T he completeness of the UPLC/QTof MS E data set is impressive. You can’t fully appreciate it until you’ve solved a major problem with it. We simply didn’t have access to these kinds of results before.”
Johnson D. Director of DMPK, MicroConstants
ACQUITY UPLC System with the Xevo G2 QTof MS System.
27
[ EXACT MASS U PLC /MALDI MS/MS ]
The SYNAPT® G2 MS is our second
Applications
generation quadrupole, oa-Tof MS
■■
Proteomics and biomarker discovery
platform. Incorporating Waters
■■
Small molecule analysis
innovative QuanTof technology, it is
■■
designed to provide a new dimension in high-resolution exact mass MS and
■■
MS/MS and quantitative performance
Peptide mapping and intact protein analysis Biopharmaceutical and protein characterization
in a timeframe compatible with UPLC
■■
Tissue imaging
separations. Central to its design is
■■
Polymer and petrochemical analysis
Engineered Simplicity™, so while it is
■■
Fine chemicals
engineered to handle your most complex
■■
Lipidomics
applications, it is also engineered to
■■
Food safety and analysis
add simplicity throughout your entire
Key Technologies
workflow. SYNAPT G2 MS is the only
■■
QuanTof Technology
application-specific system solution
■■
MS E ‘data independent’ acquisition
with the versatility to give you complete
■■
sample coverage, without compromise in performance, to meet your laboratory
■■
requirements today and the freedom
■■
to upgrade to the innovative HDMS capabilities in the future. The MALDI SYNAPT™ G2 MS System combines the speed and simplicity
■■
of MALDI with the power of QuanTof
■■
Technology to deliver the very best sensitivity, selectivity, and specificity for your discovery research challenges.
28
■■
Collision induced dissociation and electron transfer dissociation IntelliStart Technology Multiple ionization techniques: ESI, APCI, APPI, MALDI, Atmospheric Solids Analysis Probe (ASAP), Atmospheric Pressure GC (APGC), and TRIZAIC UPLC nanoTile MassLynx Software BiopharmaLynx, MarkerLynx XS, ProteinLynx Global SERVER, MetaboLynx XS, ChromaLynx, and TargetLynx application managers i-FIT™ isotope correlation, and MassFragment™ structural assignment
“ In terms of efficiency for metabolite identification studies, the accurate mass LC/MS E approach has provided significant gains… Typical savings using the approach outlined in this paper have been in the range of 13 hours per molecule. As a result the capacity for conducting preliminary metabolite identification experiments has increased by almost an order of magnitude.”
Tiller PR, et al. Drug Metabolism, Merck Research Laboratories Rapid Commun. Mass Spectrom. 2008 Apr; 22(7):1053-61.
SYNAPT G2 MS System.
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[ U PLC /MALDI IMS-MS ]
The second-generation SYNAPT G2
Applications
High Definition™ (HDMS) System
■■
Structural biology
combines enhanced high-efficiency
■■
Proteomics and biomarker discovery
ion mobility separation power
■■
Small molecule analysis
with high resolution tandem mass
■■
High Definition Imaging (HDI™) MALDI
spectrometry to deliver new
■■
Polymer analysis
levels of specificity and sample
■■
Biopharmaceutical characterization
definition, enabling researchers
■■
Fine chemicals
to differentiate samples by size,
■■
Food analysis
shape, charge, and mass.
Key Technologies
The MALDI SYNAPT G2 HDMS
■■
SYNAPT G2 HDMS
System combines the speed and
■■
MALDI SYNAPT G2 HDMS
simplicity of MALDI with ion
■■
Triwave ® Technology
mobility-based separations and
■■
high-resolution mass spectrometry to deliver enhanced specificity for the analysis of the most
■■
■■
complex mixtures and challenging discovery applications. ■■ ■■
■■
30
DriftScope™ Mobility Environment Software v.2.1 Multiple ionization techniques: ESI, ESCi™, APCI, APPI, MALDI, Atmospheric Solids Analysis Probe (ASAP), Atmospheric Pressure GC (APGC), and TRIZAIC UPLC nanoTile MassLynx Software BiopharmaLynx, MarkerLynx XS, ProteinLynx Global SERVER, MetaboLynx XS, and TargetLynx application managers MassFragment structural assignment
Learn more at www.waters.com/SYNAPT
“ …imaging IM-MS provides several unique advantages including (1) selective imaging of isobaric species (i.e. lipids versus peptides) or structural/conformational subpopulations of the same species on the basis of IM, (2) separation/rejection of undesirable endogenous chemical noise, (3) reduction of ion suppression effects in the source of the Tof- MS, by temporal IM separation of analytes, and (4) potential utility for nearly simultaneous IM-MS/ MS of all analytes at a particular pixel coordinate.”
McLean J. A., et al. Laboratory for Biological Mass Spectrometry, Texas A&M University J Mass Spectrom. 2007 Aug; 42(8):1099-105.
SYNAPT G2 HDMS System.
31
[ UNIV ERSAL IONIZATION ARCHITECTURE ]
When you need to extract the
■■
maximum amount of information from a diverse range of compounds, you require the
■■
ultimate in ionization flexibility and performance. Waters Universal Ion Source
■■
Architecture enables the widest range of ionization techniques to be utilized universally across a single analytical platform. Providing the highest performance,
■■
without compromise, the ionization source options are quick and easy to interchange.
■■
■■
■■
32
ESI/APCI/ESCi: For the analysis of polar and semipolar analytes, when coupled with the ACQUITY UPLC System. APPI/APCI: For the analysis of semi-polar and non-polar analytes when coupled with ACQUITY UPLC separations. Atmospheric pressure Solids Analysis Probe (ASAP): For the rapid analysis of volatile and semi-volatile solid and liquid samples using atmospheric pressure ionization. Atmospheric Pressure GC: Enables rapid switching from LC/MS/MS to GC/MS/MS applications on a single instrument platform. For the analysis of volatile and semi-volatile compounds of low and intermediate polarity. MALDI: For the analysis and imaging of biomolecules and synthetic polymers. NanoFlow™ ESI: For the analysis of minute sample amounts when coupled with the nanoACQUITY UPLC System. TRIZAIC UPLC nanoTile Technology: Uses micro-fabricated nanofluidic UPLC separations, it utilizes sub-2-μm particle chemistries to provide the very best chromatographic performance simply and without compromise.
“ T he chromatographic resolution and sensitivity of this novel GC/MS instrument [APGC] surpassed all expectations… every molecule we have thrown at the APGC ion source has responded well and the flexibility for optimizing the signal of choice has opened up a whole new avenue of opportunity for research.”
Mosely J. Senior Research Officer, Department of Chemistry, Durham University
APGC – Atmospheric Pressure Gas Chromatography Source.
33
[ EXACT MASS GC /MS ]
Exact mass measurements allow
Applications
compounds to be identified and
■■
Flavor and fragrance analysis
confirmed with a greater degree
■■
Metabolomic studies
of confidence than traditional
■■
Food safety screening
low-resolution MS techniques. The
■■
Unknown contaminant monitoring
GCT Premier™ Mass Spectrometer
■■
Impurity profiling
brings the specificity of exact mass
■■
measurement to GC/MS analyses. Isotope prediction/filtering
Key Technologies
software, exact mass library
■■
scoring, and a range of application
■■
specific software solutions maximize the potential of the data and allow you to rapidly get to the right answers.
34
Natural products and pharmaceutical research
■■
GCT Premier Mass Spectrometer MassLynx Software, i-FIT, and exact mass library scoring ChromaLynx, MarkerLynx, and MetaboLynx application managers
“ T he use of DRE improved mass accuracy across the tested concentration range, thus enhancing detection and quantification at higher analyte concentrations. The [GCT Premier] also provided an improvement in selectivity for the pesticides by narrowing the m/z window, giving better separation of the target compounds from coeluting compounds, which is very important when analyzing complex matrices. …The targeted approach with TargetLynx is essential for successful identification and confirmation of the analytes and ChromaLynx is a valuable tool for additional analysis, enabling untargeted analytes to be recognized.”
Leandro C. C ., et al. Central Science Laboratory, University of York J Chromatogr A. 2007 Sep 28;1166(1-2):152-62.
G CT Premier Mass Spectrometer.
35
[ QUANT ITATIV E GC /MS AND GC /MS/MS ]
Extend your MS/MS application
Applications
coverage with the Quattro micro™ GC
■■
Environmental analysis
System for superior quantitative
■■
Toxicology screening
analysis of volatile and less polar
■■
Food and beverage analysis
samples. You’ll benefit from a range of ionization capabilities and
Key Technologies ■■
introduction techniques as well as
Quattro micro GC System
■■
the high sensitivity and specificity
Dedicated EI and CI+/CI- sources
■■
of GC/MS/MS. This ensures the most comprehensive quantitative analysis of compound extracts. For the most demanding environmental and trace GC/MS quantitative assays, the AutoSpec™ magnetic sector GC/MS offers highresolution MS, unrivalled dynamic range, and customizable regulatory compliant reporting.
36
■■
Sample introduction with GC or DIP and DCI probes TargetLynx Application Manager for confirmatory quantitation and reporting
“ Analyses were performed by gas chromatography with tandem mass spectrometry (MS/MS) in electron impact mode …The excellent selectivity and sensitivity reached in selected reaction monitoring mode allowed us satisfactory quantification and confirmation at levels as low as 25 ng L-1…Analytical methodology using negative chemical ionization mode was also validated for the organochlorine compounds selected, showing a superior sensitivity and lower detection limits.”
Pitarch E., et al. Research Institute for Pesticides and Water, University Jaume I Anal Chim Acta. 2007 Feb 5;583(2):246-58.
Quattro micro GC System.
37
[ H PLC and SFC COLUMN SOLUTIONS ]
Waters is committed to advancing materials science with our continued development of ground-breaking HPLC column technologies designed to address the scientific and business challenges of our customers.
XSelect Columns
XBridge Columns
Atlantis Columns
XSelect™ HPLC Columns redefine the definition of a broadly selective modern HPLC column family. Carefully chosen ligands (C18, Phenyl-Hexyl, FluoroPhenyl) combined with proprietary Charged Surface Hybrid (CSH) Technology provide chromatographers with uniquely selective columns that deliver high analyte loading, operational stability, and full scalability from UPLC, HPLC, and preparative formats.
Possessing unmatched versatility and performance, XBridge™ Columns are the benchmark for LC method development. With superior pH stability over the widest range (1-12), high efficiencies and symmetrical peak shape, XBridge column chemistries (C18, C 8, Phenyl, Shield RP18, HILIC, and Amide) can be utilized to address challenging separations. Based upon BEH particle technology present in ACQUITY UPLC BEH Columns, XBridge Columns offer seamless method migration between HPLC and UPLC.
Atlantis HILIC Columns provide an attractive alternative separation to reversed-phase that utilizes high organic HILIC mobile phases to provide increased sample throughput and improved mass spectrometry response, in addition to exceptional polar compound retention.
38
High Strength Silica (HSS) HPLC Columns Waters developed HSS HPLC columns in response to the active feedback from our customers who have developed UPLC assays, yet require the need to transfer UPLC methods to HPLC. This is necessary in efforts to utilize existing LC systems present in other parts of an organization, or contract partners, which have not yet implemented UPLC Technology. Present in three chemistries (C18, C18 SB, and T3), and two HPLC particle sizes (3.5 and 5 μm), HSS HPLC columns enable methods to be seamlessly transferred between HPLC and UPLC systems.
Viridis SFC Columns
SunFire Columns
Designed to support the new ACQUITY UPSFC system, four new 1.7 µm SFC column chemistries based on patented Ethylene-Bridged Hybrid (BEH) particle technology were developed. New Viridis SFC chemistries include 2-Ethylpyridine, 4-Ethylpyridine, FluoroPhenyl, and unbonded BEH offer excellent peak shape and wide range of selectivity. Purification scientists can scale up to prep with these same Hybrid chemistries which are also offered in 5 µm and packed with patented Optimum Bed Density (OBD) technology for unmatched column lifetimes.
SunFire™ Columns set the performance standard in silica-based HPLC technology. With the stateof-the-art reversed-phase C18 and C 8 bonding and endcapping technologies, SunFire Columns provide best peak shape for basic compounds at low pH in addition to excellent low pH stability, high efficiency, and high mass loading capacity. SunFire Prep Columns simplify purification for low pH separations by increasing sample load through greater capacity and achieving longer lifetimes with Waters patented OBD (Optimum Bed Density) Prep Column Technology*. The SunFire Prep Column offering includes C18, C 8, and Silica (NP) chemistries. *U S Patent Number 7,399,410 and UK Patent Number GB 2408469
Order your 2010 /2011 Waters Quality Parts, Chromatography Columns, and Supplies Catalog at www.waters.com/catalog. 39
[ U PLC COLUMN SOLUTIONS ]
More and more organizations have realized the benefits of improved productivity, higher data quality, and lower cost per sample, as well as faster time-to-market, inherent in assays that utilize UPLC Technology. For these reasons, Waters continues to develop new and innovative UPLC column chemistries.
ACQUITY UPLC Columns and VanGuard Pre-Columns The ACQUITY UPLC Column family continues to evolve and expand, now including five particle substrates [BEH 130Å, BEH 200Å, BEH 300Å, HSS, and CSH] and 14 chemistries which are scalable between HPLC and UPLC particle sizes. Additionally, six application-directed UPLC chemistries for SEC, amino acid analysis, proteins, peptides, oligonucleotides, and glycan analysis are available. With a number of selectivity choices for both small molecule and biopharmaceutical applications, Waters has a UPLC column solution to meet your application needs. New ACQUITY UPLC CSH (Charged Surface Hybrid) Columns are designed to maximize chromatographic selectivity in method development and are available in C18, Fluoro-Phenyl and Phenyl-Hexyl chemistries. These are just the latest addition to the ACQUITY UPLC Column family, providing complementary selectivity to our existing portfolio. 40
ACQUITY UPLC BEH Columns (available in C18, C 8, Shield RP18, Phenyl, HILIC, Amide, SEC 200Å, 300 Å C18, and 300A C 4 chemistries), as well ACQUITY UPLC HSS Columns (available in C18, C18 SB, and T3 chemistries). All of Waters ACQUITY UPLC Columns are the only columns designed, tested, and guaranteed for routine use in applications up to 15,000 psi (1034 bar). Available in 200 plus combinations of column configurations and chemistries, ACQUITY UPLC Columns combine faster separations with higher resolution by harnessing the full potential of small particles. For UPLC column protection, VanGuard Pre-Columns feature a patentpending design that efficiently prolongs UPLC Column lifetimes in demanding applications with challenging and variable sample quality.
www.waters.com/PRIMERS
Method Transfer Kits
Method Validation Kits
New Method Transfer Kits are designed to preserve the integrity of a separation as it is transferred between UPLC and HPLC platforms. Based on the concept of maintaining column length (L) to particle size (dp) ratio (L/dp), these kits provide a ACQUITY UPLC Column with an HPLC Column of equivalent selectivity and resolving power. Using the ACQUITY UPLC Columns calculator (which can be downloaded at www.waters.com/myuplc), methods can be fully transferred from HPLC to UPLC or from UPLC to HPLC.
With exceptional batch-to-batch and column-to-column reproducibility, Waters well-established particle and column manufacturing process control provide confidence in the long-term reliability of your analytical method. ACQUITY UPLC Method Validation Kits include three batches of chromatographic media [derived from different base particles] to judge the quality, reliability, and consistency of your chromatographic method.
Method Development Kits
ACQUITY UPLC Column, VanGuard Pre-Columns, and Method Transfer Kits.
With a seemingly endless number of method parameters to try, developing a new chromatographic method can be an overwhelming, and timeconsuming experience. Waters Method Development kits consist of several UPLC Columns, encompassing a broad range in selectivity, to accommodate your method development approach and enable methods to be developed efficiently and effectively.
Learn about the techniques and technologies of analytical sciences. View our Primers at www.waters.com/primers. 41
[ BIOSEPARATIONS AND ANALYSES SOLUTIONS ]
Waters is dedicated to providing
Biomolecule Separation Technologies
innovative UPLC solutions as well as
■■
traditional HPLC-based offerings for the separation, analysis, and characterization of DNA/RNA, amino
■■
acids, peptides, proteins, and glycans. Beginning with a keen understanding of today’s biomolecule-related challenges, Waters chemistry operations scientists and engineers continuously seek
■■
purposeful innovations that help deliver impactful solutions in applications ranging from proteomics and biomarker discovery through the commercialization
■■
of advanced biopharmaceuticals.
■■
■■
IEX and SEC columns for analytical and purification applications.
42
Peptide Separation Technology Columns for nano, capillary, analytical, and preparative peptide applications Protein Separation Technology reversedphase and ion-exchange columns, as well as new SEC offerings for Waters UPLC SEC Solution, and BioSuite™, SEC, IEX, RP, and HIC Columns for HPLC-based applications AccQ•Tag™ Ultra chemistry specific for Waters UPLC Amino Acid Analysis Solution, as well as Pico•Tag™ and AccQ•Tag for HPLC based amino acid analyses Oligonucleotide Separation Technology Columns for the analysis and lab scale isolation of synthetic oligonucleotides and DNA/RNA fragments Glycan Separation Technology sample preparation columns for UPLC or UPLC/MS analysis of glycoprotein derived glycans MassPREP™ chemistry consumables and kits for MS and LC/MS applications of peptides, proteins, and other biomolecules
Harness Waters’ technologies for bioseparations and analyses.
43
[ SAM PLE P REPARATION SOLUTIONS ]
Waters offers comprehensive solutions for sample preparation challenges, regardless of your preferred sample preparation technique.
Oasis SPE Family Products
Ostro Sample Preparation Products
Combining revolutionary sorbents with innovative hardware, Oasis ® products are the preeminent choice in solid-phase extraction. Chosen for their reliable, highly selective performance, Oasis products are used by separation scientists across the globe to solve their most difficult sample preparation challenges. Relying on Oasis’ superior technical performance, researchers are able to achieve unmatched purity, consistency, and quality in their sample preparation methods.
A novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, this technology can be quickly implemented in order to optimize your laboratory’s workflow. Providing cleaner, more reproducible extracts than competitive phospholipid removal devices or techniques, the Ostro™ 96-well plate allows for more sensitive analyses, increased sample throughput, and reduced instrument downtime.
44
Learn more at www.waters.com/OSTRO
Waters Certified Vials Waters vials are certified for cleanliness by HPLC and LC/MS testing. These vials fit ACQUITY UPLC and Alliance HPLC systems and most other autosamplers on the market. For more information, visit www.waters.com/vialsselector.
Sep-Pak SPE Products Sep-Pak ® cartridges and plates are recognized throughout the world and remain the most referenced solid-phase extraction product for sample preparation. A diverse selection of formats and sorbents make Sep-Pak SPE products ideally suited for all types of samples for GC, HPLC, and UPLC analysis methods.
Sirocco 96-Well Filtration Plates Eliminates time-consuming, extra samplehandling steps traditionally done with classical PPT. Provides efficient sample processing resulting in clear filtrates from small sample volumes. Sirocco™ can be automated to process large numbers of samples efficiently.
Pall Life Sciences Sample and Solvent Filtration Products Waters offers a range of different membranes for solvent and sample compatibility. Filtration formats include apparatus for filtering solvents, and Acrodisc syringe filters for sample filtering needs.
DisQuE™ Dispersive Sample Preparation (QuEChERS) Conveniently-packaged centrifuge tubes with pre-weighed sorbents and buffers for multi-residue pesticide analysis in food.
PoraPak Rxn Products for Post Synthesis Cleanup PoraPak™ Rxn is designed for reaction cleanup in drug discovery. The product comes pre-packed in a range of sizes and is offered in bulk for the scale of reaction needs.
Waters, family of sample preparation solutions.
45
[ LABORATORY INFORMATICS SOLUTIONS ]
“ S DMS and Empower address the real need to share data among different scientists. It is clear that they [Waters] are seeing what the industry needs, and they are doing everything they can to deliver it to the customer and support the modern laboratory.”
DeSilva T. CEO, Scimcon
46
www.waters.com/INFORMATICS
Waters Laboratory Informatics solutions convert the scientific data generated in your lab into valuable information throughout your organization. With the Waters Laboratory Informatics Suite at the core of your lab, you bring together all of the information management solutions needed to compile, analyze, find, and share your data for faster and more effective decision-making. For an application-specific solution or a complete data management platform, rely on Waters Laboratory Informatics.
Applications ■■
■■
Improve data accessibility and scientific collaboration Automate and streamline laboratory workflow
■■
Compliance management
■■
Data security and traceability
■■
■■
■■
Advanced data acquisition and analysis for chromatography and mass spectrometry Authoring and reporting of scientific information with an analytical electronic laboratory notebook (ELN) Automatic information capture, cataloging, and archiving from all data sources
Key Technologies ■■
■■
■■
■■
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NuGenesis Scientific Data Management System (SDMS) and SDMS Vision Publisher™ Empower Chromatography Data Software (CDS), Method Validation Manager, and Enterprise Data Manager MassLynx Mass Spectrometry Software and Application Managers Fusion Method Development Software from S-Matrix ® UNIFI Scientific Information System, available as part of a complete application-based system solution
47
[ GLOBAL SERV ICES ]
“ We put more demands on the Waters Service team than most companies. We completed one recent project by working 34 days straight, 24 hours a day. With the help of Waters, we actually delivered the compound a week early.”
Mannerino F. Director of Chromatography and Separation Services, Regis Technologies
48
Be Assured. Choose Waters Global Services. Waters Global Services focuses on optimizing Waters products with superior service, support, upgrades, training, and Waters Quality Parts®. Only the Waters Service team has the most in-depth and up-to-date knowledge of the advanced science and technologies that provide the foundation for Waters systems. This enables Waters to help you maximize system uptime, increase laboratory productivity, and meet stringent compliance requirements. With 94 offices in more than 50 countries, Waters maintains a strong global presence. Whether your company is a single-location lab or a large multinational organization, Waters Global Services provides you with the expertise and responsiveness you need.
Services and Products ■■
■■
■■
Instrument and software support plans Automated qualification for Waters and Agilent Systems Instrument and software upgrades
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Empower Driven Services
■■
Performance Maintenance
■■
Education and training
■■
Waters Quality Parts
Application and technical support
■■
Relocation Services
■■
Asset Management
■■
■■
Remote monitoring and diagnostics
Choose Waters for Proven Satisfaction For nine consecutive years, an independent quality auditing firm ranked Waters Global Services best-in-class in providing expert technical knowledge, quick resolution of system issues, and process support.
49
Waters Centers of Innovation Program recognizes analytical scientists facilitating breakthroughs in health and life science research, food safety, environmental protection, sports medicine and many other areas.
Professor David Cowan Forensic Science and Drug Monitoring Director, Drug Control Centre King’s College London
Under the direction of Professor
Dr. Julie Leary
David Cowan, King’s College London
Professor University of California-Davis
Drug Control Centre will be responsible
Professor Leary’s use of mass
for drug testing all athletes at the 2012
spectrometry to study biological and
Olympic Games. That translates into
chemical systems, particularly how
5,000 to 6,000 samples in two weeks,
certain bacteria and viruses affect
with results back in 24 hours.
host organisms, has advanced the scientific community’s understanding of infectious diseases.
To hear more of what our customers are saying, go to www.waters.com/customers.
50
Professor Julie Leary
Dr. John Engen Associate Professor of Chemistry and Chemical Biology The Barnett Institute Northeastern University
A pioneer in the combined use of
Professor David Cowan
hydrogen-deuterium exchange (HDX) technology, UPLC and ion mobility mass spectrometry, Dr. Engen is a
Dr. Jeremy Nicholson
leading expert on understanding
Chair in Biological Chemistry Department of Surgery and Imperial College
proteins and protein confirmation, more specifically on how chemically active
Professor Nicholson was one of the
sites on a protein structure are affected
first to embrace the importance of
by conformation and the impact that
metabolic profiling, and is now Head
this might have on disease.
of one of the largest clinical academic departments in the world.
51
[ A P PLICATION SOLUTIONS ]
Biopharmaceutical
Clinical Solutions
Environmental
Fine and Specialty Chemicals
■■
Amino acids
■■
Neonatal screening
■■
Drinking water testing
■■
Structural elucidation
■■
Peptides
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Endocrinology
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Wastewater testing
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Sample profiling
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Vaccines
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Amino acid analysis
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Soil testing
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Oligonucleotides
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Tacrolimus monitoring
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Biosolid analysis
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Intact proteins
■■
■■
Air monitoring
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Carbohydrates
■■
Emerging contaminants
■■
EPA methods
Method development
■■
■■
In-process monitoring
■■ ■■
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Immunosuppressant monitoring Toxicology screening Drugs of abuse
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Impurity identification Structural confirmation
Food Profiling
Food QC and Nutritional Testing
Food Safety
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Detect adulteration
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Raw material
■■
■■
Assure authenticity
■■
Consistency
■■
■■
Confirm origin
■■
In-process monitoring
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Final product quality
■■
Mycotoxins
Verifying composition and label claims
■■
Marine biotoxins
■■
■■
Amino acid analysis in food and feed
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Pesticides Veterinary drug residues
Forensics
Pharmaceutical
Polymers
Proteomics
Tissue Imaging
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Drugs of abuse
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ADME screening
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Polymer additives
■■
Characterization
■■
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Toxicology
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Bioanalysis
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Starch
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Quantification
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Bioequivalence
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Biomarker validation
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Identification
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Processing contaminants
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Dissolution testing
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Forced degradation
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Impurity profiling
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Manufacturing
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QA/QC
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Lipidomics
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Metabolomics
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Method development
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Method validation
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Natural products
■■
Molecular weight distributions
■■
Drug/metabolite distributions
Bioseparations/ interactions
Metabolite identification
■■
■■
53
Compound library maintenance
Biomarker discovery
Traditional medicine analysis Open access
54
Food Profiling
Food QC and Nutritional Testing
Food Safety
■■
Detect adulteration
■■
Raw material
■■
■■
Assure authenticity
■■
Consistency
■■
■■
Confirm origin
■■
In-process monitoring
■■
Final product quality
■■
Mycotoxins
Verifying composition and label claims
■■
Marine biotoxins
■■
■■
Amino acid analysis in food and feed
■■
Pesticides Veterinary drug residues
Forensics
Pharmaceutical
Polymers
Proteomics
Tissue Imaging
■■
Drugs of abuse
■■
ADME screening
■■
Polymer additives
■■
Characterization
■■
■■
Toxicology
■■
Bioanalysis
■■
Starch
■■
Quantification
■■
■■
Bioequivalence
■■
■■
Biomarker validation
■■
Identification
■■
Processing contaminants
■■
Dissolution testing
■■
Forced degradation
■■
Impurity profiling
■■
Manufacturing
■■
QA/QC
■■
Lipidomics
■■
Metabolomics
■■
Method development
■■
Method validation
■■
Natural products
■■
Molecular weight distributions
■■
Drug/metabolite distributions
Bioseparations/ interactions
Metabolite identification
■■
■■
53
Compound library maintenance
Biomarker discovery
Traditional medicine analysis Open access
54
[ Product Guide 2011] Sales Offices:
Austria 43 1 877 18 07
Japan 81 3 3471 7191
Australia 61 2 9933 1777
Korea 82 2 6300 4800
Belgium and Luxembourg 32 2 726 1000
Mexico 52 55 52 00 1860
Brazil 55 11 4134 3788
The Netherlands 31 76 508 7200
Canada 1 800 252 4752
Norway 47 6 384 6050
China 86 21 6156 2666
Poland 48 22 833 4400
Czech Republic 420 2 617 11384
Puerto Rico 1 787 747 8445
Denmark 45 46 59 8080
Russia/CIS 495 727 4490 / 290 9737
Finland 358 9 5659 6288
Singapore 65 6593 7100
Whether you work in pharmaceuticals, biopharmaceuticals, environmental,
France 33 1 30 48 72 00
Spain 34 93 600 9300
food testing, clinical, or beyond, with Waters application focused solutions,
Germany 49 6196 400 600
Sweden 46 8 555 115 00
you can be assured that whenever a new analytical challenge arises,
Hong Kong 852 2964 1800
Switzerland 41 56 676 7000
Waters will have the technology and expertise to help you conquer it.
Hungary 36 1 350 5086
Taiwan 886 2 2501 9928
These solutions provide a comprehensive approach to address analytical
India 91 80 2837 1900
UK 44 208 238 6100
lab needs that include instrumentation, columns and sample prep,
Ireland 353 1 448 1500
US 1 800 252 4752
software, and support services.
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Designed by scientists for scientists, Waters solutions remove the guesswork in choosing the best way to achieve your application’s goals.
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