Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Habre W, Disma N, Virag K, et al. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe. Lancet Respir Med 2017; published online March 28. http://dx.doi. org/10.1016/S2213-2600(17)30116-9.
INCIDENCE OF SEVERE CRITICAL EVENTS IN PAEDIATRIC ANAESTHESIA: A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY IN 261 HOSPITALS IN EUROPE
Results of APRICOT: (Anaesthesia PRactice In Children Observational Trial) Web extra material Table A. Details on the participating countries, institutions, and exemption of parents/patient consent. Institutions were classified as A for dedicated paediatric hospital, B for mixed adult-paediatric teaching hospital, C for Community hospital and D for private institution.
Countries
Austria Belgium Croatia Czech Republic Denmark Estonia Finland France Germany Gibraltar Greece Ireland Israel Italy Kosovo Latvia Lithuania Malta Netherlands Norway Poland Portugal Romania Russia Serbia Slovakia Slovenia Spain Sweden Switzerland Turkey Ukraine United Kingdom Total number
Number Number of of centres included patients
Classification of participating centres
Exemption of parents/patient consent 7No 4Yes/7No 5Yes/1No 2Yes/2No Waived Waived 2Yes/1No Waived 14Yes/15No Waived 1Yes/2No Waived Waived 2Yes/23No Waived Waived 3No Waived Waived Waived 3Yes/3No 3Yes/4No 12Yes/3No 3Yes/1No 5No No No 2Yes/8No 3Yes/1No Waived 10 No Waived Waived
7 11 6 4 3 2 3 20 29 1 3 2 2 25 1 1 3 1 13 6 6 7 15 4 5 1 1 10 4 8 10 4 43
602 1,337 357 846 427 318 266 3,559 2,229 15 135 474 512 2,087 119 253 343 60 1,455 664 896 595 1,467 375 505 96 167 1,240 163 952 682 637 7,045
5B, 1C, 1D 2A, 6B, 1C, 2D 1A, 2B, 3C 1A, 3B 1A, 2B 1A, 1B 3B 5A, 12B, 1C, 2D 3A, 20B, 5C, 1D 1C 1A, 2B 1A, 1B 1A, 1D 6A, 14B, 4C, 1D 1B 1A 1A, 2B 1B 2A, 7B, 4C 5B, 1C 4A, 1B, 1C 5B, 2C 6A, 3B, 4C, 2D 3A, 1B 4A, 1B 1A 1B 2A, 7B, 1C 1A, 3C 4A, 2B, 1C, 1D 8B, 1C, 1D 1A, 1B, 2C 10A, 17B, 16C
261
30,878
63A/134B/52C/12D
Total number of paediatric cases performed in the 2 weeks and in 2012 679/18,932 1,518/31,068 365/9,420 1,033/23,232 445/7,900 344/8,069 382/8,055 3,825/78,359 2,492/66,251 15/300 263/7,998 520/14,000 533/13,000 2,481/76,230 242/3,456 260/11,428 513/15,481 60/700 1,521/45,669 675/16,148 1083/21,714 685/17,849 1,497/60,302 670/27,969 540/17,900 127/3,000 183/3,500 1,516/35,165 399/9,155 975/23,962 842/27,067 724/20,411 7,520/200,330 34,927/924,020
1
Table B. Study population characteristics and medical history. Percentages express the incidence in the whole study population. N.A. for not asked/not relevant. * indicating 10 missing values for the medical history. ** allergy was not asked for 223 (0·7%) cases. Frequency % Sex
Boys Girls White/Europeans Arabic Hispanic/Latino Asian Black-Caribbean/African Mixed cultures
Ethnicity
Medical History* Handicap/congenital disease
Yes N.A. Recent URI < 2 weeks Yes N.A. Asthma Yes N.A. Wheezing in the last 12 months Yes N.A. Atopy Yes N.A. Snoring Yes N.A. Fever > 38°C Yes N.A. Passive smoking Yes N.A. Medication Yes N.A. History of anaesthesia/complications Yes N.A. Allergy** Yes Food Nut Latex Antibiotics Pollen/Birch Dust mite NSAIDs Animal hair Myorelaxant Bees/insects Iode/contrast products Blood products Other
18,887 11,987 25,412 1,789 1,465 1,091 932 174
61·2 38·8 82·3 5·8 4·7 3·5 3 0·6
4,025 357 4,153 860 1,878 580 1,954 1,723 2,313 1,400 4,399 4,830 886 683 3,362 9,536 7,115 256 578 1,054 3,789 1,208 191 77 1,074 472 244 81 158 53 49 72 48 327
13 1·2 13·5 2·8 6·1 1·9 6·3 5·6 7·5 4·5 14·3 15·6 2·9 2·2 10·9 30·9 23·1 0·8 1·9 3·4 12·3 3·9 0·6 0·2 3·5 1·5 0·8 0·3 0·5 0·2 0·2 0·3 0·2 1·1
2
Table C. Anaesthesia plan characteristics. Percentages express the incidence estimated from the total number of procedures. § for percentages estimated from number of patients. † for percentage of outpatients· G·A· for general anaesthesia, NIRS for Near infrared spectroscopy, RSI for rapid sequence induction·* defining a procedure that is required within less than 48 hours, ** for emergency procedure where the patient’s life or organ-being jeopardised. # displaying the mean age and standard deviation of children who received premedication or had their parents present at induction. *** Standard for monitoring including electrocardiography, pulse oximetry, capnography, inhalation agent analyser, non-invasive blood pressure and temperature· Ψ for significance between mean age of children with cuffed vs uncuffed endotracheal tube (p< 0·001). NMB refers to patients who received neuromuscular blockade. Frequency Type of anaesthesia General anaesthesia Sedation Regional Stand-by Degree of urgency Admission type
Regional alone Regional with GA Regional with sedation Elective Urgent* Emergency** Outpatient Inpatient
(%)
29,064 1,961 76 7,481 297 18 25,072 4,974 826 11,703 19,424
93·4 6·3 0·2 24 1 0·06 81·2 16·1 2·7 37·6 62·4
5,790 6,287 6,163 6,038 5,323 3,144 872 654 18,344
18·6 20·2 19·8 19·4 17·1 10·1 2·8 2·1 § 59·4
6,753 15,197 15,658
§ 21·9 † 57·7 § 49·2 § 50·7
7,220 989 720 172 247 3’250
23·4 3·2 2·3 0·6 0·8 10·53
975 645
3·2 2·1
19,152 10,966
61·5 35·2
650 354
2·1 1·1
15,994 13 9,461
51·4 0·04 30·4
Procedure scheduled time Weekdays Opening hours Monday Tuesday Wednesday Thursday Friday After-hours Saturday Sunday Preoperative consultation at least 24 hrs prior to elective procedures Premedication Parental presence
Preoperative assessment for elective out-patients 6·7 ± 4·3 years # 6·3 ± 4·3 years # with premedication (43%)
Type of premedication Midazolam orally Midazolam rectally Midazolam intravenously Midazolam intranasal Clonidine orally Miscalleneous: 40 different combinations NSAID’s in combination Atropine in combination Monitoring Standard*** Standard with at least one equipment missing Invasive NIRS applied Induction of anaesthesia Inhalation
Sevoflurane Halothane
Nitrous Oxide at induction
3
Intravenous
Propofol Thiopentone Ketamine Etomidate Midazolam
15,971 1,199 653 16 1,217 16,037 9,421 3,387 1,710 1,445
30·4 2·3 1·2 0·03 2·3 51·5 30·3 10·9 5·5 4·6
1,372 641 731 592 379 116 30/15
4·4 2·1 2·3 -
28 22 30 19 52
-
13,671 9,828 48% 3,843 21% 8,367 1,134 10,919 446 4,970 1,438
44 31·6
27 3·6 35 16 16% NMB
Neostigmine Sugammadex
2,566 374
29% NMB 4% NMB
Awake Deep Left intubated
9,370 3,562 732
-
Awake Deep
6,211 4,600
-
Opioids Fentanyl Sufentanil Remifentanil Alfentanil Rapid sequence induction Modified with mask ventilation No mask ventilation Myorelaxant use (89% of cases)
Suxamethonium Rocuronium Atracurium Cisatracurium/Vecuronium
Induction technique without myorelaxant Deep level of sevoflurane Sevoflurane & opiates Sevoflurane & propofol Deep level of propofol Propofol & opiates Airway management Endotracheal intubation Cuffed # Uncuffed #
7·5 ± 4·7 years Ψ Cuff pressure monitoring 3·3 ± 2·9 years Packing inserted
Myorelaxants for tracheal intubation Vocal cords sprayed prior to intubation Supraglottic airway Myorelaxant for supraglottic airway Face mask Monitoring neuromuscular blockade Reversal of neuromuscular blockade
12·3
Removal of Endotracheal tube
Removal supraglottic airway
4
Table D1. Surgical procedures: number (n) and percentage (%) of surgical procedures (total number, n=22,952), mean age in years (SD for standard deviation), outpatient/inpatient distribution, degree of urgency, mean duration in minutes (SD) of the anaesthesia and the procedure.
n (%)
Age (mean (SD))
Outpatient/inpatient n (%)
Elective/urgent/emergency n (%)
Mean (SD) duration of anaesthesia (min)
Mean (SD) duration of procedure (min)
ENT
5,707 (25·3%)
6·0 (3·6)
2,342 (41·0%)
3,365 (59·0%)
5,317 (93·1%)
329 (5·8%)
61 (1·1%)
51·4 (46·2)
32·7 (38·1)
Gastro/abdominal
3,963 (17·5%)
5·8 (4·9)
947 (23·9%)
3,015 (76·1%)
2,487 (62·8%)
1,229 (31·0%)
246 (6·2%)
84·5 (69·7)
56·1 (56·8)
Urological/Kidney
3,641 (16%)
5·8 (4·4)
1,647 (45·2%)
1,994 (54·8%)
3,349 (92·0%)
233 (6·4%)
59 (1·6%)
73·2 (55·9)
48·6 (47·0)
Orthopaedics
3,455 (15.3%)
9·0 (4·5)
936 (27·1%)
2,519 (72·9%)
2,418 (70·0%)
893 (25·8%)
144 (4·2%)
93·9 (88·1)
62·2 (69·7)
Cutaneous/dermatology
1,143 (5·1%)
6.0 (4·6)
475 (41·6%)
667 (58·4%)
894 (78·3%)
217 (19·0%)
31 (2·7%)
52·6 (38·8)
31·0 (30·4)
Plastic (including cleft)
1,075 (4·8%)
5·6 (4·6)
344 (32·0%)
731 (68·0%)
787 (73·2%)
251 (23·3%)
37 (3·4%)
87·2 (66·2)
61·3 (55·1)
Ophtalmology
962 (4·3%)
5·5 (4·1)
559 (58·1%)
403 (41·9%)
909 (94·5%)
38 (3·9%)
15 (1·6%)
62·6 (38·1)
41·5 (31·5)
Trauma
835 (3·7%)
8·7 (4·0)
207 (24·8%)
628 (75·2%)
225 (26·9%)
515 (61·7%)
95 (11·4%)
63·2 (50·7)
40·3 (41·3)
Head and Neck
668 (3%)
7·6 (4·9)
250 (37·4%)
418 (62·6%)
532 (79·6%)
124 (18·6%)
12 (1·8%)
73·3 (76·8)
49·0 (61·0)
Neurosurgery
530 (2·3%)
6·0 (5·2)
6 (1·1%)
524 (98·9%)
336 (63·4%)
166 (31·3%)
28 (5·3%)
187·0 (138·0)
129·0 (115·0)
Cardiac surgery
256 (1·1%)
3·5 (4·7)
4 (1·6%)
252 (98·4%)
192 (75·0%)
52 (20·3%)
12 (4·7%)
254·6 (134·1)
179·1 (114·9)
Thoracic
156 (0·7%)
7.0 (6·1)
2 (1·3%)
154 (98·7%)
111 (71·1%)
40 (25·6%)
5 (3·2%)
157·2 (105·3)
102·6 (85·3)
Hepato-biliary/Pancreas
64 (0·3%)
8·2 (5·0)
2 (3·1%)
62 (96·9%)
55 (85·98%)
8 (12·0%)
1 (1·6%)
235·4 (185·7)
179·8 (154·9)
Others
137 (0·6%)
8·1 (5·1)
38 (27·7%)
99 (72·3%)
99 (72·3%)
31 (22·6%)
7 (5·1%)
96·6 (88·5)
68·6 (79·2)
5
Table D2. Non-Surgical procedures: number (n) and percentage (%) of non-surgical procedures (total number, n=9172), mean age in years (SD for standard deviation), outpatient/inpatient distribution, degree of urgency, mean duration in minutes and standard deviation (SD) of anaesthesia and procedure duration. n (%)
Age (mean (SD))
Mean (SD) duration of anaesthesia (min)
Mean (SD) duration of procedure (min)
MRI
2,055 (22·4)
4·3 (3·4)
1,267 (61·6)
788 (38·3)
1,925 (93·7)
114 (5·5)
16 (0·8)
55·1 (27·9)
40·7 (22·3)
Dental
1,650 (18·0)
7·1 (3·4)
1,449 (87·8)
201 (12·2)
1,602 (97·1)
44 (2·7)
4 (0·2)
46·1 (41·3)
32·4 (33·6)
Gastro-enterology
1,476 (16·1)
8·10(4·9)
704 (47·7)
772 (52·3)
1,266 (85·8)
191 (12·9)
19 (1·3)
40·1 (26·7)
24·4 (21·3)
Bone marrow & Lumbar puncture
915 (10·0)
6·9 (4·2)
434 (47·4)
481 (52·6)
784 (85·7)
127 (13·9)
4 (0·4)
28·2 (31·0)
18·5 (25·0)
Venous access
660 (7·2)
5·4 (4·6)
108 (16·4)
552 (83·6)
386 (58·)
262 (39·7)
12 (1·8)
64·9 (42·2)
43·1 (34·2)
Bronchoscopy
360 (3·9)
4·4 (4·2)
65 (18·1)
295 (81·9)
256 (71·1)
81 (22·5)
23 (6·4)
44·5 (25·3)
25·3 (19·1)
CT-scan
337 (3·7)
3·3 (3·2)
117 (34·7)
220 (65·3)
249 (73·9)
71 (21·1)
17 (5·1)
30·2 (31·7)
18·0 (25·3)
243 (2·6)
6·0 (5·1)
23 (9·5)
220 (90·5)
234 (96·3)
8 (3·3)
1 (0·4)
117·1 (60·2)
85·4 (54·5)
235 (2·6)
4·5 (4·0)
142 (60·4)
93 (39·6)
206 (87·6)
23 (9·8)
6 (2·5)
54·1 (46·9)
38·0 (41·9)
Burns dressing
206 (2·2)
2·9 (2·8)
76 (36·9)
130 (63·1)
170 (82·5)
33 (16·0)
3 (1·5)
37·2 (24·1)
23·2 (17·5)
Ophthalmology examination
204 (2·2)
3·3 (3·0)
157 (77·0)
47 (23·1)
199 (97·5)
5 (2·4)
0 (0·0)
38·7 (29·1)
26·0 (22·9)
Infiltration / puncture
185 (2·0)
7·1 (4·1)
123 (66·5)
62 (33·5)
176 (95·1)
8 (4·3)
1 (0·5)
35·6 (28·1)
20·2 (19·2)
Biopsy
173 (1·9)
6·8 (4·8)
49 (28·3)
124 (71·7)
142 (82·1)
31 (17·9)
0 (0·0)
52·6 (43·6)
32·3 (34·2)
Radiotherapy
130 (1·4)
4·6 (2·8)
88 (67·7)
42 (32·3)
124 (95·4)
6 (4·6)
0 (0·0)
30·0 (36·1)
19·5 (31·1)
Cystoscopy/TEE
109 (1·2)
5·3 (4·1)
33 (30·3)
76 (69·7)
99 (90·8)
10 (9·2)
0 (0·0)
38·5 (23·4)
22·5 (17·6)
Angioembolisation/scle rotherapy
99 (1·1)
7·4 (4·9)
17 (17·2)
82 (82·8)
89 (89·9)
9 (9·1)
1 (1·0)
91·2 (76·0)
62·0 (62·0)
Cast
77 (0·8)
7·0 (4·9)
9 (11·7)
68 (88·3)
37 (48·0)
38 (49·3)
2 (2·6)
37·5 (29·4)
22·5 (19·5)
Laser Eye
43 (0·5)
5·1 (3·4)
35 (81·4)
8 (18·6)
41 (95·3)
2 (4·6)
0 (0·0)
24·2 (18·9)
13·1 (18·0)
Pleural/pericardial drainage
13 (0·1)
5·4 (4·6)
0 (0·00)
13 (100·0)
2 (15·4)
9 (69·2)
2 (15·4)
38·7 (28·4)
27·8 (25·6)
Challenging intubation
2 (0·0)
9·6 (6·5)
0 (0·00)
2 (100·0)
0 (0·0)
0 (0·0)
2 (100·0)
507·0 (695·8)
15·0 (-)
Cardiac cath/His/pace maker Radiology (non interventional)
Outpatient/inpatient n (%)
Elective/urgent/emergency n (%)
6
Table E. Composition of the anaesthesia team in charge and mean years (SD) of experience of the different categories. The distribution is based on the most experienced health provider present in the room. SD for standard deviation. It is of note that a trainee was present for 8,740 procedures (28%), an anaesthetic nurse in 10,928 cases (35%) and an anaesthetic technician in 1,018 cases (3·3%).
Anaesthesia team showing percentage of practice as paediatric anaesthesia
Number of procedures performed solo
Team of 2 including 2 physicians
Team of 2 including physician and nurse/technician
Team of 3 or more with at least 3 physicians
Team of 3 or more with at least 2 physicians
Team of 3 or more with only one physician
Specialist >80% Frequent practice 50-80% Occasional practice <50% Trainee Nurses/technician
9,505 2,899
1,267 268
4,560 664
41 16
2,985 508
3,275
416
1,276
-
1,584 30/1 (7 cases with both) 17,294/17,301
-
798 -
1,951
7,298
Total
9 4
Mean years of experience (SD) of the most experienced health provider 16·3 (9·5) 13·9(8·0)
Total
18,367 4,359
987
15
14·4 (9·0)
5,969
-
-
8 -
5·7 (4·7) 12·9 (9·9)
2,390 38
57
4,480
36
31,116/31,123
7
Table F. Relative risk and 95% confidence interval (CI) for the risk factors associated with the occurrence of perioperative bronchial aspiration. Variable
Age (mean ± SD) Sex (male/female)
Univariate yes total 5·01 1,9015
n ± 14
% 4·7 0·1
no total 6·34 12,109
n ± 15
% 4·5 0·1
p
RR
0·167 0·161
0·93 0·59
Prematurity 2,363 4 0·2 25,272 24 0·1 0·284 1·78 Fever 904 0 0·0 29,522 28 0·1 Handicap 4,083 2 0·1 26,672 26 0·1 0·348 0·50 ASA Status II 8,739 10 0·1 18,883 13 0·1 0·227 1·66 3,497 6 0·2 18,883 13 0·1 0·064 2·49 ASA Status III-IV-V 8,095 9 0·1 23,030 20 0·1 0·538 1·28 Physical condition General anaesthesia/Sedation 29,064 28 0·1 1,961 1 0·1 0·532 1·89 Inpatient/outpatient 18,670 23 0·1 12,455 6 0·1 0·040 2·56 5,893 11 0.2 25,232 18 0.1 0.012 2.62 Urgent-Emergency/elective After hours/opening hours 3,133 3 0·1 27,993 26 0·1 0·960 1·03 Surgical/non-surgical 22,225 20 0·1 8,902 9 0·1 0·772 0·89 Premedication 15,263 13 0·1 15,862 16 0·1 0·650 0·84 Type of centers Mixed adult-paediatric/Paediatric 14,626 13 0·1 12,966 12 0·1 0·920 0·96 3,535 4 0·1 12,966 12 0·1 0·728 1·22 Community private hospital/Paediatric Anaesthesia team Frequent/specialist 4,359 3 0·1 18,367 20 0·1 0·459 0·63 Occasional/specialist 5,969 5 0·1 18,367 20 0·1 0·600 0·77 Trainee/specialist 2,428 1 0·0 18,367 20 0·1 0·343 0·38 Years of experience of senior person 13·31 ± 8·2 14·78 ± 9·4 0·351 0·98 2 19,598 27 0·1 11,528 2 0·0 0.013 6.14 Anesthesia Plan Induction type (intravenous/inhalation) 13,906 13 0·1 15,105 15 0·1 0·873 0·94 Myorelaxant for intubation 8,382 12 0·1 5,284 7 0·1 0·870 1·08 Rapid sequence 1,372 3 0·2 12,295 16 0·1 0·409 1·68 Cricoid pressure 540 1 0·2 1,100 2 0·2 0·988 1·02 Cuffed/uncuffed 3,843 11 0·3 9,828 8 0·1 0·007 3·52 Deep/awake extubation 3,562 5 0·1 9,370 9 0·1 0·496 1·46 Deep/awake removal SGA 4,600 3 0·1 6,211 4 0·1 0·987 1·01 Anaesthesia management 1 Variables in the multivariate model: Age, gender, physical condition, years of experience, anaesthesia plan 2 Anaesthesia plan: Urgent-emergency or after hours or inpatient
95%CI
p
0·84 0·29
-
1·03 1·23
0·62 0·12 0·73 0·95 0·58 0·26 1·04 1.24 0·31 0·40 0·41
-
5·13 2·12 3·79 6·55 2·81 13·88 6·28 5.54 3·40 1·95 1·75
0·44 0·40
-
2·10 3·79
0·19 0·29 0·05 0·95 1.46 0·45 0·43 0·49 0·09 1·41 0·49 0·23
-
2·13 2·05 2·82 1·02 25·82 1·98 2·74 5·76 11·21 8·73 4·36 4·52
Multivariate1 (n=31,064) RR 95%CI
0·162 0·137
0·93 0·60
0·85 0·31
-
1·03 1·17
0·955
1·02
0·51
-
2·03
0·376 0·004
0·98 8·43
0·93 1·97
-
1·03 36·10
8
APRICOT – List of Participating Centres and Collaborators for Publication
Austria 1. Donauspital Wien, Walter Klimscha*, Regina Konecny, Robert Luntzer, Ulrike Morawk-Wintersperger, Franz Neiger, Lydia Rustemeyer 2. Klinikum Klagenfurt, Christian Breschan, Denise Frey, Manuela Platzer* 3. Landeskrankenhaus Feldkirch, Reinhard Germann*, Joachim Oeding 4. Paracelsus Medical University Stoegermüller, Bernhard Ziegler*
Salzburg
-
LKH
Salzburg,
Birgit
5. Medical University Graz, Philipp Brotatsch, Anton Gutmann, Gerlinde Mausser, Brigitte Messerer, Wolfgang Toller, Maria Vittinghoff*, Gregor Zangl 6. Orthopädisches Spital Speising, Natascha Seidel-Ahyai * 7. University Hospital Innsbruck, Paal*
Christoph Hochhold, Ruth Kroess ,Peter
Belgium 1. AZ Sint-Jan Brugge-Oostende, Steven Cnudde*, Patricia Coucke, Birgit Loveniers 2. CHU Godinne, John Mitchell* 3. Cliniques Universitaires Saint-Luc ASBL, David Kahn*, Thierry Pirotte, Caroline Pregardien, Francis Veyckemans 4. Ghent University Hospital, Marc Coppens, Luc De Baerdemaeker, Stefan De Hert*, Björn Heyse, Martine Neckebroek, Aliaksandra Parashchanka, Jurgen Van Limmen, Nancy Van Den Eynde, Caroline Vanpeteghem, Piet Wyffels 5. Grand Hopital de Charleroi, Stevens*
Michaël Lalot, Jean-Paul Lechat, France
6. GZA Sint-Augustinus, Sari Casaer* 7. Queen Fabiola Children's University Hospital, Françoise De Groote*, Françoise De Pooter, Andrée De Villé, Marc Gerin, Natalia Magasich, Cristel Sanchez Torres, Denise Van Deenen 8. Queen Paola Children’s hospital,Antwerp Johan Berghmans*, Dirk Himpe, Eva Roofthooft 9. Universitair Ziekenhuis Antwerpen, Ellen Joukes, Carine Smitz, Veronique Van Reeth* 10. University Hospitals Leuven, Christel Huygens, Julie Lauweryns*, Karen De Smet 11. Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Nadia Najafi*, Jan Poelaert, Anne Van de Velde, Veerle Van Mossevelde
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication Croatia 1. Children's Hospital Zagreb, Ivan Bekavac, Diana Butkovic*, Dubravka Heli Litvic, Ivana Kerovec Soric, Hrvoje Maretic, Djurdjica Moscatello, Ljiljana Popovic 2. Clinical Hospital Centre Rijeka, Slobodan Mićić, Ivana Stuck Tus* 3. General Hospital Pula, Lada Kalagac Fabris* 4. General Hospital Zadar, Tatjana Simurina*, Nina Sulen 5. Opća bolnica Bjelovar, Gordana Kesić-Valpotić* 6. University Clinic of Osijek, Dajana Djapic* Czech Republic 1. University Children´s Hospital Brno, Jiří Žurek* 2. University Hospital Olomouc, Lucie Jureckova*, Iveta Mackova, Monika Skacel, Stanislava Weinlichova 3. University Hospital Ostrava, Jan Divák*, Michal Frelich, René Urbanec 4. University Hospital Prague Motol - Fakultní nemocnice v Motole, Vera Biskupova, Vladimir Mixa* , Jana Pavlickova Denmark 1. Copenhagen University Hospital, Arash Afshari*, Morten Bøttger, Marguerite B. Ellekvist, Mathias Johansen, Birgitte Ingeborg Madsen, Jens Christian Nilsson, Birgitte MB Schousboe 2. Odense University Hospital, Nicola G. Clausen, Tom G. Hansen* 3. SLB, Vejle Hospital , Nick Phaff Steen* Estonia 1. Tallinn Children`s Hospital, Mari-Liis Ilmoja*, Virge Tonise 2. Tartu University Hospital, Juri Karjagin, Reet Kikas* Finland 1. Helsinki University Central Hospital, Mika Isohanni*, Anniina Lyly, Annika Takala 2. Oulu University Hospital, Johanna Happo, Kai Kiviluoma, Kati Martikainen* 3. Turku University Hospital, Riku Aantaa, Tuula Manner*, Sanna Vilo France 1. American Memorial Hospital CHU Reims, Catherine Amory, Hugues Ludot* 2. Centre Hospitalier de Tourcoing, Patricia Lambotte*,
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 3. Centre hospitalo-universitaire de Nantes, René Busche, Olivier Jacqmarcq, Corinne Lejus* 4. CHRU de Lille Hôpital Jeanne de Flandre, Julien Corouge, Christian Erb, Delphine Garrigue, Patricia Gillet, Anne Laffargue*, Veronique Lambelin, Hélène Le Freche, Daliana Peresbota, Pierre Richart 5. CHU Angers, Jerome Berton, Catherine Chapotte, Laurent Colbus, Thierry Lehousse*, Jean Monrigal 6. CHU Bicetre, Catherine Baujard*, Philippe Roulleau, Giuseppe Staiti 7. CHU Bordeaux, Hélène Batoz, Maryline Bordes, Anne Didier, Yann Hamonic, Sylvaine Lagarde, Karine Nouette-Gaulain, François Semjen, Brigitte Zaghet* 8. CHU d'Amiens, Jacky Dekens, Axelle Delcuze, Hervé Dupont*, Aurélien Legrand, Celine Raffoflandreur 9. CHU de Grenoble, Noémie Audren*, Blandine Camus, Marielle Cartal, Chantal Chazelet, Isabelle Davin, Marion Guillier 10. CHU de Toulouse hôpital des enfants, Luc Desjeux, Claire Larcher* 11. CHU Nancy – Brabois, Elodie Grein, Mickeal Leclercq, Roxana Levitchi, Lilica Rosu, Dominique Simon, Aurélien Zang* 12. Hôpital Femme-Mère-Enfant, Bron, Anne Migeon*, Anne-Charlotte Gagey, Nathalie Bourdaud, Anne-Charlotte Carre 13. Clinique du Val d'Ouest, Frédéric Duflo*, Jean-Claude Riche, Philippe Robert 14. Hôpital Universitaire Necker Enfants Malades, Université Paris Descartes, PRES Sorbonne Paris Cité, Emilie Druot, Olivier Maupain, Gilles Orliaguet*, Lucie Sabau, Hanna Taright, Lynn Uhrig, Juliette Verchere-Montmayeur 15. Hôpital privé de Villeneuve d'Ascq, Lise Debrabant, Clotaire Pilla*, Alexandre Podvin, Benjamin Roth 16. Hôpital Robert Debré. Université Paris Diderot, PRES Sorbonne Paris Cité, Souhayl Dahmani*, Florence Julien-Marsollier 17. Hopital Trousseau, Université Paris VI Pierre et Marie Curie, Hôpitaux Universitaires de l’Est Parisien : Nada Sabourdin* 18. Hopitaux Pédiatriques de Nice CHU Lenval, Bogdan Alexandri, Gilles Brezac, Francois de la Brière*, Catherine Hayem, Elizabeth Lhubat, Jean Paul Mission, Charlotte Rémond 19. Lapeyronie University Hospital, Christophe Dadure*, Maud Maniora, Anais Marie, Philippe Pirat, Anne-Charlotte Saour, Chrystelle Sola 20. Hôpital Sud-Université Rennes 1, Claude Ecoffey*, Eric Wodey
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication Germany 1. Academic Hospital Solingen, Christian Adam, Thomas Standl* 2. Asklepios Klinik Sankt Augustin, Ehrenfried Schindler*, Tomohiro Yamamoto 3. Auf der Bult Children's Hospital, Michael Brackhahn, Christoph Bernhard Eich*, Holger Guericke 4. Childrens Hospital Amsterdamer Straße, Petra Kindermann, Laschat, Cornel Schink, Frank Wappler*
Michael
5. University Hospital Leipzig, Claudia Hoehne*, Natalia Skordou, Johanna Ulrici 6. Duesseldorf University Hospital, Martin Jetzek-Zader, Peter Kienbaum, Tanja Meyer-Treschan*, Olaf Picker, Maximilian S. Schaefer 7. Elisabeth-Krankenhaus Essen, Golo Mielke* 8. Evangelische Elisaebeth Klinik Berlin, Sabine Baethge, Axel Ramminger* 9. Georg-August-University, Martin Bauer, Matthias Bollinger, José Hinz*, Michael Quintel, Sebastian G. Russo 10. Jena University Hospital, Michael Bauer, Dfominik Geil, Andreas Kortgen*, Niels-Peter Preussler 11. Kinderkrankenhaus Sankt Marien, Ulrich Hofmann, Manfred Raber*, Doris Reindl 12. Klinik Hallerwiese/Cnopf´sche Kinderklinik, Karin Becke*, Karin Oppenrieder, Bettina Schierlinger, Jens Roth 13. Klinikum Amberg, Wolfgang Funk* 14. Klinikum Kassel, Thomas Fischer, Christian Gernoth*, Christina Wiefelspütz 15. Klinikum Nuernberg Hauke Volger*, Nicole Zederer 16. Klinikum Oldenburg gGmbH, Anja Diers, Matthias Huber, Clemens Schorer, Andreas Weyland* 17. Klinikum Saarbruecken, Konrad Schwarzkopf* 18. Klinikum Traunstein, Catharina Grau, Winfried Roth* 19. Krankenhaus St. Elisabeth und St. Barbara Halle, Rolf Holy, Thomas Mader*, Laura Peter, Hauke Supthut 20. Marienhospital Osnabrueck, Thomas Kuehhirt, Alexander Milde* 21. St. Elisabeth-Krankenhaus, Fritz Fiedler, Carsten Isselhorst* 22. Universitätsklinikum des Saarlandes, Ulrich Grundmann, Alexander Pattar, Jennifer Reinert*
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 23. University Hospital Carl Gustav Carus, Birgit Ehm, Katrin Fritzsche, Ralf Gaebler* 24. University Hospital Frankfurt, Patrick Meybohm* 25. University Hospital of Wuerzburg, Maximilian Hein, Ines Guzman, Johanna Jokinen, Peter Kranke* 26. University Medical Centre Freiburg, Ulrich Goebel*, Sarah Harris 27. University Medical Centre Mannheim, Christoph Eisner, Miriam Ochsenreiter, Michael Schoeler, Elke Thil* 28. University of Bonn, Richard Ellerkmann*, Andreas Hoeft, Claudia Neumann Stefan Weber 29. University Hospital of Cologne, Julia Keilhauer, Jan Kloessing, Michael Schramm, Uwe Trieschmann* 30. University Hospital Regensburg, Kristina Knauss, Barbara Sinner*, Johannes Steinmann Gibraltar 1. Gibraltar Health Authority, St. Bernard´s Hospital, Herbert Koessler* Greece 1. Children Hospital P&A Kyriakou, Evagelia Kalliardou, Anna Malisiova*, Adelais Tsiotou 2. Demokritous University of Thrase , Pelagia Chloropoulou* 3. Hippokrateion General Hospital Thessaloniki, Mpratzou Chrysi, Despoina Iordanidou*, Merkourios Ntavlis Hungary 1. University of Szeged, Ferenc Rarosi, Krisztina B Boda* Ireland 1. Our Lady’s Children's Hospital, Crumlin, Christilynn Guerin Claire Magner Solmaz Nakhjavani Brendan O'Hare*
Janice Irwin
2. Waterford Regional Hospital, Deborah Galvin* Israel 1. Herzliya Medical center, Yosry Jamil, Carlos Lesmes* 2. Schneider Children's Medical center of Israel, Yuri Barak, Haran Fisher, Ludmyla Kachko, Jacob Katz*, Dmitry Kirilov, Michael Levinzon, Yair Manevich, Konstantin Nekrasov, Elia Peled, Elena Sanko, Dmitri Schmain,
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication Olga Sheinkin, Eliahu Simhi, Alex Tarabikin, Evelina Trabkin, Irena Yagudaev, Yelena Zeitlin, Igor Zunser Italy 1. AOU Città della Salute e della Scienza di Torino, Elisabetta Cerutti*, Maria Maddalena Schellino, Silvia Valzan 2. ASST-Ovest Milanese Ospedale Civile di Legnano, Rosa Lucia Pinciroli* 3. Azienda Ospedaliero Universitaria di Parma, Luciano Bortone*, Giorgia Cerati, Fabiana Salici 4. Azienda Ospedaliera Universitaria Meyer - Ospedale Pediatrico Meyer, Leonardo Bussolin, Giuliana Rizzo*, Francesca Rossetti* 5. Azienda Ospedaliero-Universitaria Perugia, Laura Marchesini, Simonetta Tesoro* 6. Azienda Ospedaliero-Universitaria Guarracino, Beate Kuppers*
Pisana,
Brita
De
Lorenzo,
Fabio
7. Azienda Ospedaliero-Universitaria “Policlinico-Vittorio Emanuele”, Policlinico “G Rodico”, Catania, Marinella Astuto*, Sofia Pitino, Rita Scalisi, Lucia Scordo 8. Bambino Gesù Hospital Sandra D'Alessandro, Luigi Dei Giudici, Ivano Farinelli, Giuseppe Lofino, Giuliano Marchetti, Sergio Giuseppe Picardo, Simone Reali, Alessandro Vittori* 9. Catholic University of Sacred Heart, Policlinico “A. Gemelli” Rome, Francesco Antonio Idone, Maria Sammartino*, Fabio Sbaraglia 10. Istituto Giannina Gaslini, Cinzia Barbera, Michela Bevilacqua, Valeria Cento, Nicola Disma*, Svetlana Kotzeva, Leila Mameli, Giovanni Montobbio, Leandro Passariello, Cinzia Punzo, Rosanna Sileo, Rosanna Viacava, Claudia Volpe, Clelia Zanaboni 11. IRCCS Fondazione Policlinico Ca Granda, Edoardo Calderini, Daniele Genco, Simona Neri*, Davide Ottolina 12. ASST FBF SACCO Ospedale dei Bambini Vittore Buzzi, Anna Camporesi, Francesca Izzo, Ida Salvo, Andrea Wolfler* 13. Niguarda Ca' Granda, Andrea Sanna, Angela Sciascia, Paolo Stoia* 14. Ospedale dei Bambini G. Di Cristina, Annamaria Guddo*, Maria Lapi 15. Ospedale Infantile Regina Margherita, Giorgio Ivani*, Annalisa Longobardo, Valeria Mossetti 16. Ospedale S. Chiara,Trento, Dino Pedrotti* 17. Padova Hospital, Maurizia Grazzini, Luisa Meneghini, Salvatore Metrangolo, Stefania Michelon, Carmelo Minardi, Costanza Tognon, Nicola Zadra*
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 18. Papa Giovanni XXIII, Ilaria Busi, Magda Khotcholava, Bruno Guido Locatelli*, Valter Sonzogni, Giusi Starita 19. University La Sapienza, Policlinico Umberto I, Nicole Almenrader* 20. Second University of Naples, Caterina Aurilio*, Pasquale Sansone 21. St. Orsola-Malpighi University Hospital, Raffaella Albarello Paolo Bracci Mariateresa Cecini Maria Cristina Mondardini Lorena Pasini* 22. University Hospital of Ferrara, Milo Vason*, Gianluca Zani, Roberto Zoppellari 23. University Hospital of Sassari, Laura Pistidda* 24. University of Palermo. Policlinico P.Giaccone, Andrea Cortegiani*, Santi Maurizio Raineri Kosovo 1. Faculty of Medicine, University of Prishtina, University Clinical Center of Kosovo, Antigona Hasani*, Medita Hashimi Latvia 1. Riga Children University Hospital, Agris Ancupans, Arta Barzdina, Zane Straume*, Anda Zundane Lithuania 1. Children hospital of Klaipeda, Mikhail Chlopin*, Dalia Gestautaite, 2. Lithuanian University of Health Sciences Medical Lukosiene*, Evelina Paliokaite, Ilona Razlevice
Academy,
Laura
3. Vilnius Children Hospital, Inesa Armoniene, Aurelija Bernotiene, Vidunas Daugelavicius*, Ilona Dockiene, Lina Gaidelyte, Nijole Saviciene, Jolita Krikstaponiene, Dominika Sidlovskaite-Baltake, Vladyslav Stasevski, Agne Vaitoskaite Malta 1. Mater Dei Hospital, David Gatt, Stephanie Mifsud, Simone Zammit* Netherlands 1. Amsterdam Medical Center (AMC), Celia Allison, Hamid Aslami, Susanne Eberl, Mireille F M van Stijn, Markus F Stevens* 2. Atrium Medisch Centrum, Kees Punt*, Rob van Osch 3. Catharina hospital, Arthur Bauwman, Harm Scholten, Vesna Svircevic* 4. Erasmus MC-Sophia Childrens Hospital, Veronique Adriaens, Maaike Dirckx, Jaap Dogger, Ilse Dons-Sinke, Andreas Machotta, Xavier Moors, Mandana
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication Rad, Lonneke Staals*, Anouk van der Knijff - van Dortmont, Caroline van der Marel 5. Haga Teaching Hospital, Anne Sieben, Tim van der Zwan*, Marianne Veldhuizen 6. Leiden University Medical Center, David Alders* 7. Maastricht University Medical Centre, Wolfgang Buhre, Petronella M Vermeulen*, Nicole Engel, Carine Vossen 8. Maxima Medical Centre, Ravin Mahadewsing, Patrick Meijer* 9. Meander Medisch Centrum Amersfoort, Volker Gerling, Schatte Olivier, Thea van Doorn*, Kristy Vons
Roelof van der
10. Radboud University Medical Centre, Mark Hendriks*, Sandra Lako, Gert jan Scheffer, Luc Tielens, Marieke Voet 11. University medical centre Groningen, Anthony Absalom, Margot Bergsma, Vera Spanjer, Rob Spanjersberg, Yvette van de Riet, Martin Volkers* 12. Wilhelmina Children's Hospital, UMCU, Jurgen C. de Graaff*, Geranne A. J. Hopman, Teus H. Kappen, J. Hannie A. M. Megens, Sandra C. Numan, Anton N. J. Schouten, Nigel M. Turner, Désirée B.M. Van Der Werff, Renee T. M. Wensing 13. Zaans Medisch Centrum, Erik Ephraim, Claire Nolte* Norway 1. Haukeland University Hospital, Tore Reikvam* 2. Hospital of Oestfold, Ole Fredrik Lund* , Lene Skaaden 3. Oslo University Hospital, Rikshospitalet, Kari Marthe Ballovarre, Wenche Bakken Boerke*, Guro Grindheim, Pal H H Lindenskov, Anne Beate Solas, Sjur Sponheim, Kyrre Ullensvang, Oddbjorn Viken 4. Oslo University Hospital - Ullevål, Inger Marie Drage* 5. University Hospital of Northern Norway, Kasper Gymoese Berthelsen*, Bjørn Anders Kroken 6. University Hospital of Stavanger, Unni Bergland* Poland 1. Childrens University Hospital Bialystok, Mirosław Pryzmont, Mariola Talalaj*, Malgorzata Wasiluk, Dorota Zalewska 2. John Paul II Upper Silesian Child Health Centre in Katowice, Maria Damps*, Jadzia Siemek-Mitela, Pawel Wieczorek 3. Karol Jonscher’s University Hospital Poznan, Magdalena Juzwa, Jowita Rosada-Kurasinska, Alicja Bartkowska-Sniatkowska*
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 4. L.Rydygier Regional Hospital in Toruń, Maciej Cettler*, Renata Kopycinska, Iwona Rudewicz, Jaek Sobczyk, Dariusz Wojciechowski 5. Medical University of Warsaw, Artur Baranowski, Ewa Basiewicz, Magdalena Mierzewska-Schmidt*, Wlodzimierz Retka, Piotr Sawicki 6. University Hospital Wroclaw, Magdalena Checinska, Marzena Zielinska*, Magdalena Zurawska Portugal 1. Centro Hospitalar do Porto, Teresa Leal, Catia Mascarenhas, António Pedro Pina*, Maria Joao Susano 2. Centro Hospitalar Lisboa Central, Antonio Moniz, Maria Teresa Rocha*, Carolina Calvao Santos 3. Centro Hospitalar Lisboa Norte - Hospital de Santa Maria, M Domingas Patuleia*, Ricardo Pereira, Helena Roxo 4. Centro Hospitalar Tondela-Viseu ,Rosa Amaral*, Isabel Guedes 5. Hospital de Braga, Cristina Gomes, Marta Gonçalves, Helena Salgado, Maria Santos* 6. Santarem Hospital, Sara Rodrigues, Angela Sa* 7. Unidade Local de Saúde de Matosinhos, Elvira Machado, Sandra Pé d'Arca, Manuel Seabra* Romania 1. Children's Clinical Hospital, Ligia Mihaela Gheorghe*, Constantin Ivascu, Lucia Moraru-Draghici, Mirela Suvejan 2. Children's Emergency Hospital, Remus Babici, Kovacs Eniko, Cristiana Hogea*, Dubau Mihaela Daraban Nicoleta 3. County Emergency Hospital Sf.Ioan cel Nou Suceava, Danut Barbunc, Alina Maria Nistor*, Violeta Stefan 4. Emergency children's hospital Grigore Alexandrescu, Gabriela Catalina Ionescu, Irina Davidescu, Alina Teodora Nastase, Florin Dumitru Rusu* 5. Emergency Clinical Hospital of Constanta, Victoria Badarau*, Iulia Cindea 6. Emergency Clinic Hospital of Ophthalmology Bucharest, Melania Moscaliuc, Dana Olteanu, Luxita Petrescu* 7. Emergency County Hospital Bacau, Daniela Ceuca*, Irena Galinescu 8. Louis Turcanu Emergency Children Hospital, Rodica Badeti*, Alin Capusan, Cosmina Cucui-Cozma, Barbura Popescu 9. Sf. Constantin Hospital, Luminita Cimpeanu*
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 10. Sf. IOAN - Children's Hospital Galati, Mihaela-Petronela Birliba, Magdalena Miulescu* 11. Emergency Children Hospital “Maria Curie” – Bucharest. Stefania Balamat, Adriana Gurita, Luminita Ilie, Gabriel Mocioiu, Darina Pick, Rodica Sirghie, Radu Tabacaru*, Irinel Trante, Adriana Gurita, 12. Spital Orasenesc Bolintin Vale, Lucian Horhota* 13. Spital Regina Maria, Daniela Bandrabur* 14. St. Maria Children's Hospital, Tudor Ciobanu, Veaceslav Cuciuc, Valentin Munteanu*, Valentin Olaru, Corneliu Paiu, Anca Savu, Oana Trifan, 15. Universitary Emergency Hospital nr.1 Craiova, Anca Elena Malos* Russia 1. Morozov Children Hospital, Anton Glazunov, Alexander Ivanov, Evgeny Poduskov*, Alexander Popov 2. Moscow Regional Research and Clinical Institute (MONIKI), Igor Guskov, Alexander Lugovoy, Vladislav Nechaev, Alexey Ovezov* 3. Pirogov Russian National Research Medical University, Mikhail Basov, Vladimir Kochkin, Vladimir Lazarev* 4. Russian Medical Academy Postgraduate Education, Dmitri Chizhov, Ivan Ostreikov*, Konstantin Tolasov Serbia 1. Clinic for Pediatric Surgery and Orthopedics, Clinical Centre Nis, Ivana Budic*, Vesna Marjanovic 2. Institute for child and youth healthcare of Vojvodina, Novi Sad, Biljana Draskovic*, Marina Pandurov, Jovana Simin 3. Clinical Centre of Vojvodina, Novi Sad, Serbia, Vladimir Dolinaj, Dusanka Janjevic* 4. Mother and Child Healthcare Institute, Ana Mandras, Maja Mircetic, Sladjana Petrovic, Vlatka Rebac, Bojana Slavkovic, Vesna Stevanovic*, Ana Velcev 5. University Childrens Hospital, Belgrade, Mirjana Knezevic, Irina Milojevic*, Selena Puric, Irena Simic, Marija Stevic, Vladimir Stranjanac, Dusica Simic Slovakia 1. University Children Hospital Banska Bystrica, Barbora Cabanova, Miloslav Hanula*, Slovenia 1. University Klinical Centre Ljubljana, Andry Grynyuk, Jelena Berger*, Uros Cerne, Andraz Nastran, Dejan Pirc, Rok Popic, Spela Stupnik
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication Spain 1. 12 de Octubre University Hospital, Paloma Rubio*, Cristina del Río, Pilar Benito, Gema Pino, Ignacio Gutierrez 2. Hospital Clinico Universitario Valencia, León Carsi*
Andrea Gutierrez Valcarcel, Irene
3. Hospital General de la Palma, Anibal Perez Garcia* 4. Hospital Of Sabadell, Sílvia López Galera*, Joan Marco Valls, Laura Ricol Lainez, Andrea Vallejo Tarrat 5. Hospital Sant Joan de Déu, University Paediatric Hospital Espluges de Llobregat, Barcelona, David Artes, Ester Banus, Luca Chirichiello, Leidy De Abreu, Belen De Josemaria, M Helena Gaitan, Antonio Garces, Juan J Lazaro, Ferran Manen Berga*, Dolors Molies, Enric Monclus, Montserrat Navaro, Carmen Pamies, Marina Perelló, Mar Prat, Laura Ribo, M Angeles Sanz, Silvia Serrano, Eva Sola Ruiz* 6. Hospital Universitario Cruces, Blanca Anuncia Escontrela Rodríguez, Andrea Maria Gago Martinez, Alberto Martínez Ruiz* 7. La Paz University Hospital, Maria Del Carmen Cuatecontzi Flores, Fausto De La Cruz Benito, Gustavo Gabilondo Garcia, Ever Martinez Maldonado, Bryant Noriega, Lara Oller Duque, Alberto Olmos Mendez, Antonio PerezFerrer*, Francisco Reinoso Barbero 8. Ramon y Cajal Hospital, Ismael Acevedo Bambaren*, Fernando Domínguez 9. Hospital Universitari Germans Trias i Pujol, Teresa Franco*, Anabel Jiménez, Alicia Melero 10. Vall d'Hebron Hospital, Montserrat Feliu, Irene García*, Núria Montferrer, Francisca Munar, Cristina Muro, Rosario Nuño, Remel Perera, Erika Schmucker Sweden 1. Centralsjukhuset i Kristianstad, Glenda Börjesson, Lars Gillberg* 2. Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Albert Castellheim*, Kerstin Sandström
University
of
3. Falu Lasarett, Annette Bauer*, Torbjörn Roos 4. Skelleftea Lasarett, Lars Hedlund* Switzerland 1. Centre Hospitalier Universitaire Vaudois, Yann Boegli, Mirko Dolci*, Carine Marcucci 2. Hôpital de la Tour, Isabelle Spahr-Schopfer* 3. Hôpitaux Universitaires de Genève, Walid Habre, Michel Pellegrini* 4. Inselspital, University Hospital Bern, Malte Book*, Loreen Errass, Christine Riggenbach
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 5. Kantonsspital Luzern, Mattias Casutt*, Martin Hölzle, Thomas Hurni, Martin Jöhr, Jacqueline Mauch 6. Ospedale San Giovanni, Luciano Anselmi*, Irene Anselmi 7. Ostschweizer Kinderspital St. Gallen, Alfred Jacomet, Markus Oberhauser*, Stephanie Wossner, Angelika Zettl 8. University Children's Hospital Basel, Thomas Erb*, Tomasz Mackiewicz, Helena Simitzes Turkey 1. Anadolu Health Center, Yetkin Ozer, Arzu Takil* 2. Ankara University Medical School - Cebeci Hospital, Zekeriyya Alanoglu*, Onat Bermede, K.Sanem Cakar Turhan, 3. Ankara University Medical School - Ibni Sina Hospital, Neslihan Alkis*, Cigdem Yildirim Guclu, Basak Ceyda Meco 4. Cukurova University Faculty Of Medicine, Zehra Hatipoglu, Dilek Ozcengiz* 5. Inonu Univ. Medical School, Zekine Begec*, Huseyin Ilksen Toprak 6. Istanbul University Cerrahpasa Medical Faculty, Pinar Kendigelen*, Ayse Ciğdem Tütüncü 7. Istanbul University, Istanbul Medical Faculty, Meltem Savran Karadeniz*, Tulay Seyhan Ozkan, Nuket Sivrikoz 8. Marmara University, Mustafa Kemal Arslantas, Ayse Hizal, Gülbin Tore Altun, Tumay Umuroglu* 9. Ondokuz Mayıs University, Sibel Baris* 10. UFUK University Hospital, Zuleyha Kazak Bengisun* Ukraine 1. OKHMATDYT National Children's Hospital, Galyna Goncharenko, Maksym Khrapak, Tetyana Klymenko, Vitaliy Pavlenko, Dmytro Prysiazhniuk, Olga Rudio, Mykhailo Varyvoda, Sergii Vodianytskyi* 2. P.L.Shupyk National Medical Academy of Postgraduate Education, Ivanna Boryshkevych, Iryna Kyselova*, Nikolay Trikash 3. Regional Children's Clinic Hospital, Cukurova Regional Children's Clinic Hospital, Andrew Albokrinov*, Valentina Perova-Sharonova 4. Regional Children Hospital Mikhail Isak, Vitaliy Sklyar, Denis Surkov* United Kingdom 1. Addenbrooke's Hospital, Amr Abdelaal, Nicola Barber*, Sarah Checuti, Leisha Godsiff, Lynch Johanne, Joanna Simpson, Helen Underhill 2. Alder Hey Children's NHS FoundationTrust, Rishi Diwan, Nivedita Kelgeri, Nuria Masip, Radha Ravi, Steve Roberts*
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 3. Birmingham Children's Hospital, Annagrazia Cillis, Ritchie Marcus*, Federica Merella 4. Borders General Hospital, David Love* 5. Broomfield Hospital, Paolo Baraggia*, Victoria Bird, Joseph Hussey 6. Calderdale & Huddersfield NHS Foundation Trust, Peter Alderson, Karen Bartholomew*, Michael Moncreiff 7. Chelsea and Westminster Foundation Trust, Sarah Davidson, Alison Hare, Ami Kotecha, Corina Lee*, Ganga Liyanage, Shivali Patel, Amee Samani 8. Derriford Hospital Plymouth NHS Trust, Mark Abou-Samra, Matthew Boyd, Laurence Hullatt*, David Levy, Mark Pauling, Sarah-Jane Sharman, Natalie Smith 9. Dumfries & Galloway Royal Infirmary, John Rutherford* 10. East Surrey Hospital, Alison Cavalier, Christie Locke, Frederic Sage* 11. Evelina London Children's Hospital, Smita Bapat, Jacinda Hammerschlag, Ioannis Ioannou, Stephanie King*, Rachel Pegg, Vishal Salota, Jonathan Sketcher, Muthu Thadsad, Deborah Zeitlin 12. Forth Valley Hospital, Ewan Jack*, Colin Lang 13. Great North Children's Hospital, Royal Victoria Infirmary, Samira Ahmed*, Reema Ayyash, Francoise Bari, Sarah J Bell, Claire Elizabeth Biercamp, Sandra Briggs, Maria Gabriella Elena Clement, Mark Dalton, Mohamed Ali Eissa Eid, Monica Gandhi, Idse Harmen Herrema, Ranj Khaffaf, Savio Jeng Min Law, Joanna McClintock, Nicholas Ireland, Mohammed Majid Saleem, Fiona Smith 14. Great Ormond Street Hospital for Children NHS Foundation Trust, Marc Cohen, Clover-Ann Lee, Lizanne O'Donahue, Alex Powell, Ellen Rawlinson*, Aarjan Snoek, Katja Weiss, Hugo Wellesley* 15. Hairmyres Hospital, Michael Crawford* 16. Hull and East Yorkshire Hospitals NHS Trust, Mostafa Abdel-Hafiz*, Alexandra Day, Balaji Rajamani, Rita Saha, Dave Wright 17. Inverclyde Royal Hospital, Lew-Chin Chee* 18. Leeds Chidrens hospital - Leeds General Infirmary, Stephanie Bew*, Rachel Homer, Nalini Malarkkan, Juliet Wolfe Barry 19. Leicester Royal infirmary, Pradeep Angadi, Brid Cagney, Eric De Melo, Elsa Dekker*, Emma Helm, Gareth Jones, Kawshala Peiris, William Russell, Patricia Slater, Puja Sodhi 20. Maidstone hospital - Maidstone and Tunbridge Wells NHS Trust, Mike Browning*, Trudie Phillips, Rachel Van Hecke 21. Monklands Hospital, Vimty Muir*
* site lead investigators
APRICOT – List of Participating Centres and Collaborators for Publication 22. Morriston Hospital, ABMU Health Board, Piyush Singh*, Tereza Soskova 23. Ninewells Hospital, Craig Cumming*, Pamela Farquharson, Karen Pearson, Neil Shaw 24. Raigmore Hospital, Jonathan Whiteside*, Emma Whyte 25. Royal Aberdeen Children's Hospital, Gordon Byers, Kay Davies, Thomas Engelhardt*, Isabella Faliszewski, Graham Johnston, Nils Kaufmann, Zuzana Kusnirikova, Graham Wilson 26. Royal Alexandra Hospital, Peter Carachi, Andrew Makin* 27. Royal Belfast Hospital for Sick Children, Brian Foster*, Dariusz Lipczynski 28. Royal Cornwall Hospital Trust, Rebecca Mawer, William Rutherford* 29. Royal Derby Hospital, David Rogerson*, Sarah Rushman, Christopher Taylor, William Tomlinson 30. Royal Devon and Exeter NHSFT, Philippa Dix*, Tom Woodward 31. Royal Hospital For Children, Glasgow, Graham Bell, David Boyle, Marianne Cloherty, Julia Cullen, Pauline Cullen, Ross Fairgrieve, Robert Ghent, Russell Glasgow, Elena Gordeeva, Alison Harden, Sarah Hivey, Kevin Jerome, Lesley McKee, Neil Morton*, Vicky Pribul, John Sinclair, Maria Steiner, Heather Steward, Lorraine Sweeney, Wendy Thomson, Jeanette Whiteside 32. Royal Hospital for Sick Children Edinburgh, Andrew Dalton, Mark Ross, Carolyn Smith* 33. Royal Manchester Children's Hospital, Claire Allen, Nicola Anders, Victoria Barlow, Mike Bassett, Leanne Darwin, Rachel Davison, Jacques Diacono, Amy Hobbs, Adel Hutchinson, Bernadette Lomas, Hannah Lonsdale, Leila Nasser, Vimmi Oshan*, Pradip Patel, Christopher Raistrick, Victoria ScottWarren, Laura Talbot, Carolynn Wai 34. Royal Surrey County Hospital,Sophie Childs, Matthew Dickinson* 35. St. John's Hospital, Livingston, Tom Bloomfield, Sweyn Garrioch, Karen Watson* 36. Salisbury District Hospital, James Gaynor*, Richard Harrison, Juliette Lee 37. Sheffield Childrens Hospital, Elizabeth Blythe, Teresa Dorman, Ayman Eissa, James Ellwood, Ingrid Gooch, Robert Hearn, Vanessa Hodgetts, Robert John, Christine Kirton, Nadia Ladak, Judith Morgan, Nina Plant, Elizabeth Shepherd, Judith Short, Charles Stack, Simon Steel, Matthew Taylor*, Deborah Thomas, Catharine Wilson, Elaine Wilson-Smith 38. University Hospital Coventry, Carol L. Bradbury*, Nageena Hussain, Antonia Mayell, Ahmed Mesbah, Arif Qureshi, Chandra Vaidyanath 39. University Hospital Crosshouse, Tim Tamaraichelvi Parasuraman, Nicole Perry
* site lead investigators
Geary*,
Chris
Hawksworth,
APRICOT – List of Participating Centres and Collaborators for Publication 40. University Hospital Southampton, Indrani Banerjee, Katharine Barr, Patrick Butler, Jack Davies, Lisa Flewin*, Richard Gande, James Montague, James Plumb, Thomas Pratt, Paul Sutherland, Matthew Taylor, Hannah Vail, Andrew Wilkins 41. Victoria Hospital, Catherine Hunter*, Susan Russell 42. West Wales General Hospital, Alun Thomas* 43. Wishaw General Hospital, Mark Mifsud*, Dominic Strachan Management Team Brigitte Leva, European Society of Anaesthesiology aisbl (Brussels), Belgium Benoit Plichon, European Society of Anaesthesiology aisbl (Brussels), Belgium Pierre Harlet, European Society of Anaesthesiology aisbl (Brussels), Belgium Chief investigator Walid Habre Hôpitaux Universitaires de Genève, Genève, Switzerland
* site lead investigators
