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Musculoskeletal Multisite Pain and Patterns of Association After Adjusting for Sleep, Physical Activity and Screen Time in Adolescents. 2.499

PMID 29557924

Spine 2018 Mar 19

DOI 10.1097/BRS.0000000000002646



Silva AG, Couto PS, Queirós A, Neto M, Rocha NP

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STUDY DESIGN:cross-sectional. OBJECTIVE:This study aims to describe how pain at multiple body sites is associated after controlling for other predictive factors such as age, gender, sleeping hours, time spent in physical activity and time spent in screening based activities in adolescents aged 13 to 19 years old. SUMMARY OF BACKGROUND DATA:The prevalence of multisite pain in adolescents is high but studies investigating the patterns of association between painful body sites are scarce. METHODS:Pain for the last 3 months was assessed using Nordic Musculoskeletal Questionnaire (NPQ). In addition, data on time spent in moderate and vigorous physical activity, sleeping and in screen based activities was also (0) (100) Endnote assessed. RESULTS:In univariable analysis of associations, there is a significant association between most painful body sites (OR between 1.52 and 3.73, p<0.05). After controlling for age, sex, physical activity, sleep and screen time, most of the TiO-based (FeO, SiO, reduced graphene oxide) magnetically recoverable previous associations remain significant (OR between 1.50 and 3.07, p<0.05). photocatalysts for imazalil degradation in a synthetic wastewater. CONCLUSIONS:This study results seem to suggest that pain at one body site is more important in determining multiple painful body sites than demographic or lifestyle factors. Longitudinal studies exploring the association and chronology 2.741 PMID 29557041 Environ Sci Pollut Res Int 2018 Mar 02 of multisite pain are needed. DOI 10.1007/s11356-018-1586-1 LEVEL OF EVIDENCE:3. ¯

Santiago DE, Pastrana-Martínez LM, Pulido-Melián E, Araña J, Faria JL, Silva AMT, González-Díaz Ó, Doña-Rodríguez JM ­

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Magnetite (FeO), a core-shell material (SiO@FeO), and reduced graphene oxide-FeO(referred as rGO-MN) were used as supports of a specific highly active TiOphotocatalyst. Thermal treatments at 200 or 450 °C, different atmospheres (air or N), and TiO:support weight ratios (1.0, 1.5, or 2.0) were investigated. X-ray diffractograms revealed that magnetite is not oxidized to hematite when the core-shell SiO@FeOmaterial-or a Natmosphere (instead of air) in the thermal treatment-was employed to prepare the TiO-based catalysts (the magnetic properties being preserved). The materials treated with Nwere first tested for degradation of imazalil (a well-known fungicide) in deionized water. The best compromise between the photocatalytic activity, magnetic separation, and Fe leached (1.61 mg L, i.e., below the threshold for water reuse in irrigation) was found for the magnetic catalyst prepared with SiO@FeO, an intermediate (0) (100) Endnote TiO:support ratio (1.5), and treated at 200 °C under Natmosphere (i.e., [email protected]). This material was then tested for the treatment of imazalil in a synthetic wastewater, SW (with a chemical composition simulating an effluent resulting from fruit postharvest activity). This SW has a pH of 4.2 and the experiments were carried out at this Heterologous expression of three antigenic proteins from Angiostrongylus natural pHand at neutral conditions (keeping pH at 7 along the reaction). The magnetic catalyst was more active than cantonensis: ES-7, Lec-5, and 14-3-3 in mammalian cells. bare TiOfor the treatment of imazalil in SW at natural pH. Since Fe leaching was observed (3.53 mg L), added HOenhanced both imazalil degradation and mineralization. Conveniently, these catalysts can be readily recovered by 2.536 PMID 29555232 Mol. Biochem. Parasitol. 2018 Mar 16 using a conventional magnetic field, as demonstrated over three consecutive recycling runs. Graphical abstract % DOI 10.1016/j.molbiopara.2018.03.001 Imazalil conversion using different magnetic catalysts and comparison with bare TiO. Cognato BB, Handali S, Morassutti AL, da Silva AJ, Graeff-Teixeira C

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Angiostrongylus cantonensis is a parasitic nematode and the main causative agent of human cerebral eosinophilic meningoencephalitis (EoM). A definitive diagnosis of EoM usually requires serologic or molecular analysis of the patient's clinical sample. Currently, a 31kDa antigen is used in immunological tests for this purpose, however as a crude antigen preparation it may present cross-reactivity with other helminthic infections, especially echinococcosis. Heterologous expression studies using prokaryotic systems failed on producing antigenic proteins. The aim of this study was to express and purify three recombinant glycoproteins representing A. cantonensis antigens: ES-7, Lec-5, and 14-3-3, in Chinese hamster ovary (CHO) cells and ES-7 in human embryonic kidney (HEK) cells to develop a source of specific antigens to be used in the diagnosis of angiostrongyliasis. The potential diagnostic value of these (0) (100) Endnote three proteins was subsequently characterized in one- and two-dimensional electrophoresis and Western blot to dot blot analyses, with Angiostrongylus-positive sera, normal human sera (NHS), and a pool of Echinococcus-positive sera (included as a specificity control) used for detection. In addition, recognition of these three proteins following treatment Antibacterial naphthoquinone derivatives targeting resistant strain Gram-negative with N-glycosidase F was examined. The ES-7 proteins that were expressed in HEK and CHO cells, and the Lec-5 bacteria in biofilms. protein that was expressed in CHO cells, were specifically recognized by A. cantonensis-positive sera in the 2D electrophoresis analysis. This recognition was shown to be dependent on the presence of glycidic portions, making 2.009 PMID 29550501 Microb. Pathog. 2018 Mar 14 ;118 mammalian cells a very promising source of heterologous expression antigenic proteins from Angiostrongylus. DOI 10.1016/j.micpath.2018.03.024 Novais JS, Moreira CS, Silva ACJA, Loureiro RS, Sá Figueiredo AM, Ferreira VF, Castro HC, da Rocha DR

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The aims of this study were the planning, synthesis and in vitro evaluation of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]naphthoquinones against Gram-negative and Gram-positive strains, searching for potential lead compounds against bacterial biofilm formation. A series of 12 new analogs of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinones were synthesized by adding a thiol and different substituents to a -quinone methide using microwave irradiation. The compounds were tested against Gram-positive (Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, S. simulans ATCC 27851, S. epidermidis ATCC 12228 and a hospital Methicillin-resistant S. aureus (MRSA) strain), as well as Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, P. aeruginosa ATCC 15442, Proteus mirabilis ATCC 15290, Serratia marcescens ATCC 14756, Klebsiella pneumoniae (0) (102) Endnote ATCC 4352 and Enterobacter cloacae ATCC 23355) strains, using the disk diffusion method. Ten compounds showed activity mainly against Gram-negative strains with a minimal inhibitory concentration (MIC=4-64µg/mL) within the Clinical and Laboratory Standards Institute (CLSI) levels. The biofilm inhibition data showed compounds, 9e, 9f, 9j and A new species of Cystoisospora Frenkel, 1977 (Apicomplexa: Sarcocystidae) from 9k, are anti-biofilm molecules when used in sub-MIC concentrations against P. aeruginosa ATCC 15442 strain. Oecomys mamorae Thomas (Rodentia: Cricetidae) in the Brazilian Pantanal. Compound (9j) inhibited biofilm formation up to 63.4% with a better profile than ciprofloxacin, which is not able to prevent biofilm formation effectively. The reduction of P. aeruginosa ATCC 15442 mature biofilms was also observed 1.181 PMID 29549562 Syst. Parasitol. 2018 Mar 16 DOI 10.1007/s11230-018-9788-y for 9e and 9k. The structure modification applied in the series resulted in 12 new naphthoquinones with antimicrobial activity against Gram-negative bacteria strains (E. coli ATCC 25922, P. aeruginosa ATCC 27853 and ATCC 15442). Barreto WTG, de Andrade GB, Viana LA, de Oliveira Porfírio GE, Santos FM, Perdomo AC, do Carmo JS, da Silva AR, ¯ Four compounds decreased P. aeruginosa biofilm formation effectively. Maltezo TR, Herrera HM ­ Despite the great diversity of coccidians, to our knowledge, no coccidian infections have been described in Oecomys spp. In this context, we examined Oecomys mamorae Thomas (Rodentia: Cricetidae) from the Brazilian Pantanal for infections with enteric coccidia. Nine individuals were sampled, and one was found to be infected. The oöcysts were recovered through centrifugal flotation in sugar solution. Using morphological and morphometric features, we described a new species of Cystoisospora Frenkel, 1977. Sporulated oöcysts were ovoidal 20.0-29.1 × 16.4-23.2 (26.7 × 21.2) µm and contained two sporocysts, 12.9-19.1 × 9.4-13.9 (16.4 × 12.4) µm, each with four banana-shaped sporozoites. Polar granule and oöcyst residuum were both absent. We documented the developmental forms in the small intestine and described the histopathological lesions in the enteric tract. Our results indicate that the prevalence of (0) (100) Endnote Cystoisospora mamorae n. sp. in O. mamorae is low, and tissue damage in the enteric tract is mild, even in the presence of coccidian developmental stages.

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Determination of main fruits in adulterated nectars by ATR-FTIR spectroscopy combined with multivariate calibration and variable selection methods. 4.529

PMID 29548454

DOI 10.1016/j.foodchem.2018.02.015

Food Chem 2018 Jul 15 ;254



Miaw CSW, Assis C, Silva ARCS, Cunha ML, Sena MM, de Souza SVC

Grape, orange, peach and passion fruit nectars were formulated and adulterated by dilution with syrup, apple and cashew juices at 10 levels for each adulterant. Attenuated total reflectance Fourier transform mid infrared (ATR-FTIR) spectra were obtained. Partial least squares (PLS) multivariate calibration models allied to different variable selection methods, such as interval partial least squares (iPLS), ordered predictors selection (OPS) and genetic algorithm (GA), were used to quantify the main fruits. PLS improved by iPLS-OPS variable selection showed the highest predictive capacity to quantify the main fruit contents. The selected variables in the final models varied from 72 to 100; the root mean square errors of prediction were estimated from 0.5 to 2.6%; the correlation coefficients of prediction ranged from 0.948 to 0.990; and, the mean relative errors of prediction varied from 3.0 to 6.7%. All of the developed models (0) (100) Endnote were validated.

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From localization to anomalous diffusion in the dynamics of coupled kicked rotors. 2.366

PMID 29548167

DOI 10.1103/PhysRevE.97.022202

Phys Rev E 2018 Feb ;97(2-1)



Notarnicola S, Iemini F, Rossini D, Fazio R, Silva A, Russomanno A

We study the effect of many-body quantum interference on the dynamics of coupled periodically kicked systems whose classical dynamics is chaotic and shows an unbounded energy increase. We specifically focus on an N-coupled kicked rotors model: We find that the interplay of quantumness and interactions dramatically modifies the system dynamics, inducing a transition between energy saturation and unbounded energy increase. We discuss this phenomenon both numerically and analytically through a mapping onto an N-dimensional Anderson model. The thermodynamic limit NÕ∞, in particular, always shows unbounded energy growth. This dynamical delocalization is genuinely quantum and very different from the classical one: Using a mean-field approximation, we see that the system self-organizes so that the energy per site increases in time as a power law with exponent smaller than 1. This wealth of phenomena is a (0) (100) Endnote genuine effect of quantum interference: The classical system for N≥2 always behaves ergodically with an energy per site linearly increasing in time. Our results show that quantum mechanics can deeply alter the regularity or ergodicity properties of a many-body-driven system.

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Diffuse correlation tomography in the transport regime: A theoretical study of the sensitivity to Brownian motion. 2.366

PMID 29548080

DOI 10.1103/PhysRevE.97.022408

Phys Rev E 2018 Feb ;97(2-1)



Tricoli U, Macdonald CM, Durduran T, Da Silva A, Markel VA

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Diffuse correlation tomography (DCT) uses the electric-field temporal autocorrelation function to measure the meansquare displacement of light-scattering particles in a turbid medium over a given exposure time. The movement of blood particles is here estimated through a Brownian-motion-like model in contrast to ordered motion as in blood flow. The sensitivity kernel relating the measurable field correlation function to the mean-square displacement of the particles can be derived by applying a perturbative analysis to the correlation transport equation (CTE). We derive an analytical expression for the CTE sensitivity kernel in terms of the Green's function of the radiative transport equation, which describes the propagation of the intensity. We then evaluate the kernel numerically. The simulations demonstrate that, in the transport regime, the sensitivity kernel provides sharper spatial information about the medium (0) (101) Endnote as compared with the correlation diffusion approximation. Also, the use of the CTE allows one to explore some additional degrees of freedom in the data such as the collimation direction of sources and detectors. Our results can be used to improve the spatial resolution of DCT, in particular, with applications to blood flow imaging in regions where the A Novel Betabaculovirus Isolated from the Monocot Pest Mocis latipes Brownian motion is dominant.

(Lepidoptera: Noctuidae) and the Evolution of Multiple-Copy Genes. 3.465

PMID 29547534

Viruses 2018 Mar 16 ;10(3)

DOI 10.3390/v10030134



Ardisson-Araújo DMP, da Silva AMR, Melo FL, Dos Santos ER, Sosa-Gómez DR, Ribeiro BM

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In this report, we described the genome of a novel baculovirus isolated from the monocot insect pest, the striped grass looper. The genome has 134,272 bp in length with a G + C content of 38.3%. Based on the concatenated sequence of the 38 baculovirus core genes, we found that the virus is a betabaculovirus closely related to the noctuid-infecting betabaculoviruses including Pseudaletia unipuncta granulovirus (PsunGV), Trichoplusia ni granulovirus (TnGV), Helicoverpa armigera granulovirus (HearGV), and Xestia c-nigrum granulovirus (XecnGV). The virus may constitute a newspecies tentatively named Mocis latipes granulovirus (MolaGV). After gene content analysis, five open reading frames (ORFs) were found to be unique to MolaGV and several auxiliary genes were found including,,,, and three. The virus genome lacked bothand. We then looked at the evolutionary history of thegene and found that betabaculovirus (0) (100) Endnote acquired this gene from an alphabaculovirus followed by several duplication events. Gene duplication also happened to an-like gene. Genomic and gene content analyses revealed both a strict collinearity and gene expansion into the genome of the MolaGV-related species. We also characterized the granulin gene using a recombinant Autographa GW170817: Implications for the Stochastic Gravitational-Wave Background from californica multiple nucleopolyhedrovirus (AcMNPV) and found that occlusion bodies were produced into the nucleus of Compact Binary Coalescences. infected cells and presented a polyhedral shape and no occluded virions within. Overall, betabaculovirus genome sequencing is of importance to the field as few genomes are publicly accessible.is a secondary pest of maize, rice, and 8.462 PMID 29547330 Phys. Rev. Lett. 2018 Mar 02 ;120(9) wheat crops in Brazil. Certainly, both the discovery and description of novel baculoviruses may lead to development of DOI 10.1103/PhysRevLett.120.091101 greener and safer pesticides in order to counteract and effectively control crop damage-causing insect populations. ¯

Abbott BP, Abbott R, Abbott TD, Acernese F, Ackley K, Adams C, Adams T, Addesso P, Adhikari RX, Adya VB, Affeldt C, Afrough M, Agarwal B, Agathos M, Agatsuma K, Aggarwal N, Aguiar OD, Aiello L, Ain A, Ajith P, Allen B, Allen G, Allocca The LIGO Scientific and Virgo Collaborations have announced the event GW170817, the first detection of gravitational A, Altin PA, Amato A, Ananyeva A, Anderson SB, Anderson WG, Angelova SV, Antier S, Appert S, Arai K, Araya MC, waves from the coalescence of two neutron stars. The merger rate of binary neutron stars estimated from this event Areeda JS, Arnaud N, Arun KG, Ascenzi S, Ashton G, Ast M, Aston SM, Astone P, Atallah DV, Aufmuth P, Aulbert C, suggests that distant, unresolvable binary neutron stars create a significant astrophysical stochastic gravitational-wave background. The binary neutron star component will add to the contribution from binary black holes, increasing the AultONeal K, Austin C, Avila-Alvarez A, Babak S, Bacon P, Bader MKM, Bae S, Baker PT, Baldaccini F, Ballardin G, amplitude of the total astrophysical background relative to previous expectations. In the Advanced LIGO-Virgo Ballmer SW, Banagiri S, Barayoga JC, Barclay SE, Barish BC, Barker D, Barkett K, Barone F, Barr B, Barsotti L, Barsuglia frequency band most sensitive to stochastic backgrounds (near 25 Hz), we predict a total astrophysical background with amplitude _{GW}(f=25Hz)=1.8_{-1.3}^{+2.7}×10^{-9} with 90% confidence, compared with _{GW}(f=25 M, Barta D, Bartlett J, Bartos I, Bassiri R, Basti A, Batch JC, Bawaj M, Bayley JC, Bazzan M, Bécsy B, Beer C, Bejger M, Hz)=1.1_{-0.7}^{+1.2}×10^{-9} from binary black holes alone. Assuming the most probable rate for compact binary (0) (100) Endnote Belahcene I, Bell AS, Berger BK, Bergmann G, Bero JJ, Berry CPL, Bersanetti D, Bertolini A, Betzwieser J, Bhagwat S, mergers, we find that the total background may be detectable with a signal-to-noise-ratio of 3 after 40 months of total observation time, based on the expected timeline for Advanced LIGO and Virgo to reach their design sensitivity. Bhandare R, Bilenko IA, Billingsley G, Billman CR, Birch J, Birney R, Birnholtz O, Biscans S, Biscoveanu S, Bisht A, Bitossi

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Changes in the cerebral phosphotransfer network impair energetic homeostasis in M, Biwer C, Bizouard MA, Blackburn JK, Blackman J, Blair CD, Blair DG, Blair RM, Bloemen S, Bock O, Bode N, Boer M, an aflatoxin B-contaminated diet. Bogaert G, Bohe A, Bondu F, Bonilla E, Bonnand R, Boom BA, Bork R, Boschi V, Bose S, Bossie K, Bouffanais Y, Bozzi A, 1.647 PMID 29546539 Fish Physiol. Biochem. 2018 Mar 15 Bradaschia C, Brady PR, Branchesi M, Brau JE, Briant T, Brillet A, Brinkmann M, Brisson V, Brockill P, Broida JE, Brooks DOI 10.1007/s10695-018-0493-1 AF, Brown DA, Brown DD, Brunett S, Buchanan CC, Buikema A, Bulik T, Bulten HJ, Buonanno A, Buskulic D, Buy C, Byer

Baldissera MD, Souza CF, Zeppenfeld CC, Descovi S, da Silva AS, Baldisserotto B RL, Cabero M, Cadonati L, Cagnoli G, Cahillane C, Bustillo JC, Callister TA, Calloni E, Camp JB, Canepa M, Canizares P, Cannon KC, Cao H, Cao J, Capano CD, Capocasa E, Carbognani F, Caride S, Carney MF, Diaz JC, Casentini C, Caudill

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The phosphotransfer network system, through the enzymes creatine kinase (CK), adenylate kinase (AK), and pyruvate S, Cavaglià M, Cavalier F, Cavalieri R, Cella G, Cepeda CB, Cerdá-Durán P, Cerretani G, Cesarini E, Chamberlin SJ, kinase (PK), contributes to efficient intracellular energetic communication between cellular adenosine triphosphate Chan M, Chao S, Charlton P, Chase E, Chassande-Mottin E, Chatterjee D, Cheeseboro BD, Chen HY, Chen X, Chen Y, (ATP) consumption and production in tissues with high energetic demand, such as cerebral tissue. Thus, the aim of this study was to evaluate whether aflatoxin B(AFB) intoxication in diet negatively affects the cerebral phosphotransfer Cheng HP, Chia H, Chincarini A, Chiummo A, Chmiel T, Cho HS, Cho M, Chow JH, Christensen N, Chu Q, Chua AJK, network related to impairment of cerebral ATP levels in silver catfish (Rhamdia quelen). Brain cytosolic CK activity Chua S, Chung AKW, Chung S, Ciani G, Ciolfi R, Cirelli CE, Cirone A, Clara F, Clark JA, Clearwater P, Cleva F, Cocchieri decreased in animals fed with a diet contaminated with AFBon days 14 and 21 post-feeding, while mitochondrial CK activity increased, when compared to the control group (basal diet). Also, cerebral AK and PK activity decreased in C, Coccia E, Cohadon PF, Cohen D, Colla A, Collette CG, Cominsky LR, Constancio M, Conti L, Cooper SJ, Corban P, animals fed with a diet contaminated with AFBon days 14 and 21 post-feeding, similarly to the results observed for (0) (100) Endnote Corbitt TR, Cordero-Carrión I, Corley KR, Cornish N, Corsi A, Cortese S, Costa CA, Coughlin MW, Coughlin SB, Coulon cerebral ATP levels. Based on this evidence, inhibition of cerebral cytosolic CK activity is compensated by stimulation of mitochondrial CK activity in an attempt to prevent impairment of communication between sites of ATP generation and JP, Countryman ST, Couvares P, Covas PB, Cowan EE, Coward DM, Cowart MJ, Coyne DC, Coyne R, Creighton JDE, ATP utilization. The inhibition of cerebral AK and PK activity leads to impairment of cerebral energy homeostasis, Maternal 5CpG Imprints at theandDifferentially Methylated Regions Are Decoupled Creighton TD, Cripe J, Crowder SG, Cullen TJ, Cumming A, Cunningham L, Cuoco E, Dal Canton T, Dálya G, Danilishin decreasing the brain's ATP availability. Moreover, the absence of a reciprocal compensatory mechanism between From Parent-of-Origin Expression Effects in Multiple Human Tissues. these enzymes contributes to cerebral energetic imbalance, which may contribute to disease pathophysiology. SL, D'Antonio S, Danzmann K, Dasgupta A, Da Silva Costa CF, Dattilo V, Dave I, Davier M, Davis D, Daw EJ, Day B, De 3.789 PMID 29545821 Front Genet 2018 ;9 DOI 10.3389/fgene.2018.00036 S, DeBra D, Degallaix J, De Laurentis M, Deléglise S, Del Pozzo W, Demos N, Denker T, Dent T, De Pietri R, Dergachev

V, De Rosa R, DeRosa RT, De Rossi C, DeSalvo R, de Varona O, Devenson J, Dhurandhar S, Díaz MC, Di Fiore L, Di de Sá Machado Araújo G, da Silva Francisco Junior R, Dos Santos Ferreira C, Mozer Rodrigues PT, Terra Machado D,

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Giovanni M, Di Girolamo T, Di Lieto A, Di Pace S, Di Palma I, Di Renzo F, Doctor Z, Dolique V, Donovan F, Dooley KL, Louvain de Souza T, Teixeira de Souza J, Figueiredo Osorio da Silva C, Alves da Silva AF, Andrade CCF, da Silva AT,

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A hallmark of imprinted genes in mammals is the occurrence of parent-of-origin-dependent asymmetry of DNA cytosine Doravari S, Dorrington I, Douglas R, Dovale Álvarez M, Downes TP, Drago M, Dreissigacker C, Driggers JC, Du Z, Ducrot Ramos V, Garcia AB, Machado FB, Medina-Acosta E ­ methylation (5C) of alleles at CpG islands (CGIs) in their promoter regions. This 5CpG asymmetry between the M, Dupej P, Dwyer SE, Edo TB, Edwards MC, Effler A, Eggenstein HB, Ehrens P, Eichholz J, Eikenberry SS, Eisenstein parental alleles creates allele-specific imprinted differentially methylated regions (iDMRs). iDMRs are often coupled to the transcriptional repression of the methylated allele and the activation of the unmethylated allele in a tissue-specific, RA, Essick RC, Estevez D, Etienne ZB, Etzel T, Evans M, Evans TM, Factourovich M, Fafone V, Fair H, Fairhurst S, Fan developmental-stage-specific and/or isoform-specific fashion. iDMRs function as regulatory platforms, built through the X, Farinon S, Farr B, Farr WM, Fauchon-Jones EJ, Favata M, Fays M, Fee C, Fehrmann H, Feicht J, Fejer MM, recruitment of chemical modifications to histones to achieve differential, parent-of-origin-dependent chromatin segmentation states. Here, we used a comparative computational data mining approach to identify 125 novel Fernandez-Galiana A, Ferrante I, Ferreira EC, Ferrini F, Fidecaro F, Finstad D, Fiori I, Fiorucci D, Fishbach M, Fisher RP, constitutive candidate iDMRs that integrate the maximal number of allele-specific methylation region records (0) (100) Endnote Fitz-Axen M, Flaminio R, Fletcher M, Fong H, Font JA, Forsyth PWF, Forsyth SS, Fournier JD, Frasca S, Frasconi F, Frei overlapping CGIs in human methylomes. Twenty-nine candidate iDMRs display gametic 5CpG asymmetry, and another 96 are candidate secondary iDMRs. We established the maternal origin of the 5CpG imprints of one gametic () and one Z, Freise A, Frey R, Frey V, Fries EM, Fritschel P, Frolov VV, Fulda P, Fyffe M, Gabbard H, Gadre BU, Gaebel SM, Gair secondary () iDMRs. We also found a constitutively hemimethylated, nonimprinted domain at thepromoter CGI with JR, Gammaitoni L, Ganija MR, Gaonkar SG, Garcia-Quiros C, Garufi F, Gateley B, Gaudio S, Gaur G, Gayathri V, Zooplankton From a Reef System Under the Influence of the Amazon River Plume. oocyte-derived methylation asymmetry. Given that the 5CpG level at the iDMRs is not a sufficient criterion to predict active or silent locus states and that iDMRs can regulate genes from a distance of more than 1 Mb, we used RNA-Seq Gehrels N, Gemme G, Genin E, Gennai A, George D, George J, Gergely L, Germain V, Ghonge S, Ghosh A, Ghosh A, 4.076 PMID 29545783 Front Microbiol 2018 ;9 DOI 10.3389/fmicb.2018.00355 experiments from the Genotype-Tissue Expression project and public archives to assess the transcriptional expression Ghosh S, Giaime JA, Giardina KD, Giazotto A, Gill K, Glover L, Goetz E, Goetz R, Gomes S, Goncharov B, González G, profiles of SNPs across 4.6 Mb spans around the novel maternal iDMRs. We showed thatandare expressed biallelically Neumann-Leitão S, Melo PAMC, Schwamborn R, Diaz XFG, Figueiredo LGP, Silva AP, Campelo RPS, de Melo Júnior in multiple tissues. We found evidence of tissue-specific monoallelic expression ofand, located 363 kb upstream and Gonzalez Castro JM, Gopakumar A, Gorodetsky ML, Gossan SE, Gosselin M, Gouaty R, Grado A, Graef C, Granata M, M, Melo NFAC, Costa AESF, Araújo M, Veleda DRA, Moura RL, Thompson F ­ 419 kb downstream, respectively, of theiDMR. We hypothesize that theiDMR regulates the tissue-specific, monoallelic Grant A, Gras S, Gray C, Greco G, Green AC, Gretarsson EM, Groot P, Grote H, Grunewald S, Gruning P, Guidi GM, expression ofbut not of. We annotated the non-coding epigenomic marks in the two maternal iDMRs using data from At the mouth of the Amazon River, a widespread carbonate ecosystem exists below the river plume, generating a hardthe Roadmap Epigenomics project and showed that theandiDMRs achieve contrasting activation and repression bottom reef (~9500 km) that includes mainly large sponges but also rhodolith beds. The mesozooplankton associated Guo X, Gupta A, Gupta MK, Gushwa KE, Gustafson EK, Gustafson R, Halim O, Hall BR, Hall ED, Hamilton EZ, Hammond chromatin segmentations. Lastly, we found that the maternal 5CpG imprints are perturbed in several hematopoietic with the pelagic realm over the reef formation was characterized, considering the estuarine plume and oceanic G, Haney M, Hanke MM, Hanks J, Hanna C, Hannam MD, Hannuksela OA, Hanson J, Hardwick T, Harms J, Harry GM, cancers. We conclude that the maternal 5CpG imprints atandiDMRs are decoupled from parent-of-origin transcriptional influence. Vertical hauls were carried out using a standard plankton net with 200 µm mesh size during September expression effects in multiple tissues. 2014. An indicator index was applied to express species importance as ecological indicators in community. Information Harry IW, Hart MJ, Haster CJ, Haughian K, Healy J, Heidmann A, Heintze MC, Heitmann H, Hello P, Hemming G, Hendry

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on functional traits was gathered for the most abundant copepod species. Overall, 179 zooplankton taxa were M, Heng IS, Hennig J, Heptonstall AW, Heurs M, Hild S, Hinderer T, Hoak D, Hofman D, Holt K, Holz DE, Hopkins P, Horst recorded. Copepods were the richest (92 species), most diverse and most abundant group, whereas meroplankton were rare and less abundant. Species diversity (>3.0 bits.ind) and evenness (>0.6) were high, indicating a complex C, Hough J, Houston EA, Howell EJ, Hreibi A, Hu YM, Huerta EA, Huet D, Hughey B, Husa S, Huttner SH, Huynh-Dinh T, (0) (100) Endnote community. Small holoplanktonic species dominated the zooplankton, and the total density varied from 107.98 ind. Indik N, Inta R, Intini G, Isa HN, Isac JM, Isi M, Iyer BR, Izumi K, Jacqmin T, Jani K, Jaranowski P, Jawahar S, Jiménezmover the reef area to 2,609.24 ind. min the estuarine plume, with a significant difference between coastal and oceanic areas. The most abundant copepods were the coastal speciesandand early stages copepodites of Paracalanidae. The Forteza F, Johnson WW, Jones DI, Jones R, Jonker RJG, Ju L, Junker J, Kalaghatgi CV, Kalogera V, Kamai B, Rickettsia amblyommatis infecting Amblyomma pseudoconcolor in area of new holoplanktonic, an important producer of mucous houses, was very abundant on the reefs. The indicator species index Kandhasamy S, Kang G, Kanner JB, Kapadia SJ, Karki S, Karvinen KS, Kasprzack M, Katolik M, Katsavounidis E, focus of spotted fever in northeast Brazil. revealed three groups: (1) indicative of coastal waters under the influence of the estuarine plume [and Hydromedusae]; (2) characterized coastal and oceanic conditions (); (3) characterized the reef system (). Two major copepods Katzman W, Kaufer S, Kawabe K, Kéfélian F, Keitel D, Kemball AJ, Kennedy R, Kent C, Key JS, Khalili FY, Khan I, Khan 2.218 PMID 29545159 Acta Trop. 2018 Mar 12 DOI 10.1016/j.actatropica.2018.03.005 functional groups were identified and sorted according to their trophic strategy and coastal-oceanic distribution. The S, Khan Z, Khazanov EA, Kijbunchoo N, Kim C, Kim JC, Kim K, Kim W, Kim WS, Kim YM, Kimbrell SJ, King EJ, King PJ, species that dominated the coastal area and the area over the rhodolith beds are indicators of the estuarine plume and Silva AB, Cardoso KM, de Oliveira SV, Costa RMF, Oliveira G, Amorim M, Alves LC, Monteiro MFM, Gazeta GS are mixed with species of the North Brazil Current. These species practically disappear offshore, where occur oceanic Kinley-Hanlon M, Kirchhoff R, Kissel JS, Kleybolte L, Klimenko S, Knowles TD, Koch P, Koehlenbeck SM, Koley S, species commonly found in other oligotrophic tropical areas. This ecosystem shows a mixture of estuarine, coastal and Kondrashov V, Kontos A, Korobko M, Korth WZ, Kowalska I, Kozak DB, Krämer C, Kringel V, Krishnan B, Królak A, Kuehn oceanic communities coexisting in the waters over the Amazon reefs, with no significant differences among these In Brazil, active infections of Rickettsia spp. is confirmed in all regions, involving various species of ticks. During areas. However, the MDS clearly separated the communities along the salinity gradient in the plume. G, Kumar P, Kumar R, Kumar S, Kuo L, Kutynia A, Kwang S, Lackey BD, Lai KH, Landry M, Lang RN, Lange J, Lantz B, investigation of a new focus of Spotted Fever (SF) incidence in the state of Pernambuco, northeastern Brazil, tick



species Rhipicephalus sanguineus sensu lato (Latreille), and Amblyomma pseudoconcolor were collected from one Lanza RK, Lartaux-Vollard A, Lasky PD, Laxen M, Lazzarini A, Lazzaro C, Leaci P, Leavey S, Lee CH, Lee HK, Lee HM, Canis familiaris and four Dasypus novemcinctus, respectively, and analized for the presence of rickettsial genes. Ten Lee HW, Lee K, Lehmann J, Lenon A, Leonardi M, Leroy N, Letendre N, Levin Y, Li TGF, Linker SD, Littenberg TB, Liu J, A. pseudoconcolor ticks (90.9%) were found to be infected with Rickettsia, whereas no evidence of Rickettsia spp. was found in R. sanguineus s. l. Genetic analysis based of five rickettsial genes showed that the detected strain is most Lo RKL, Lockerbie NA, London LT, Lord JE, Lorenzini M, Loriette V, Lormand M, Losurdo G, Lough JD, Lousto CO, closely related to Rickettsia amblyommatis (formerly Candidatus Rickettsia amblyommii). R. amblyommatis was, for the Lovelace G, Lück H, Lumaca D, Lundgren AP, Lynch R, Ma Y, Macas R, Macfoy S, Machenschalk B, MacInnis M, first time, detected in Amblyomma pseudoconcolor and the results pointed to this tick like a potential vector in the (0) (100) Endnote enzootic cycle of R. amblyommatis in a typical semiarid Brazilian savannah region. In conclusion, despite the need for Macleod DM, Magaña Hernandez I, Magaña-Sandoval F, Magaña Zertuche L, Magee RM, Majorana E, Maksimovic I, further studies to confirm if R. amblyommatis was responsible for the observed case in the state of Pernambuco, the Man N, Mandic V, Mangano V, Mansell GL, Manske M, Mantovani M, Marchesoni F, Marion F, Márka S, Márka Z, presence of this bacterium during an SF focussed investigation should be a major concern in terms of public health due The Diagnostic Yield of Brugada Syndrome After Sudden Death With Normal the capacity of SF for rapid and extensive dispersion within Brazilian territory. Markakis C, Markosyan AS, Markowitz A, Maros E, Marquina A, Martelli F, Martellini L, Martin IW, Martin RM, Martynov

Autopsy.

DV, Mason K, Massera E, Masserot A, Massinger TJ, Masso-Reid M, Mastrogiovanni S, Matas A, Matichard F, Matone L, 19.896 PMID 29544603 J. Am. Coll. Cardiol. 2018 Mar 20 ;71(11) Mavalvala N, Mazumder N, McCarthy R, McClelland DE, McCormick S, McCuller L, McGuire SC, McIntyre G, McIver J, DOI 10.1016/j.jacc.2018.01.031

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McManus DJ, McNeill L, McRae T, McWilliams ST, Meacher D, Meadors GD, Mehmet M, Meidam J, Mejuto-Villa E, Papadakis M, Papatheodorou E, Mellor G, Raju H, Bastiaenen R, Wijeyeratne Y, Wasim S, Ensam B, Finocchiaro G, Melatos A, Mendell G, Mercer RA, Merilh EL, Merzougui M, Meshkov S, Messenger C, Messick C, Metzdorff R, Meyers Gray B, Malhotra A, D'Silva A, Edwards N, Cole D, Attard V, Batchvarov VN, Tome-Esteban M, Homfray T, Sheppard MN, PM, Miao H, Michel C, Middleton H, Mikhailov EE, Milano L, Miller AL, Miller BB, Miller J, Millhouse M, Milovich-Goff MC, BACKGROUND:Familial evaluation after a sudden death with negative autopsy (sudden arrhythmic death syndrome; Sharma S, Behr ER ­ SADS) may identify relatives at risk of fatal arrhythmias. Minazzoli O, Minenkov Y, Ming J, Mishra C, Mitra S, Mitrofanov VP, Mitselmakher G, Mittleman R, Moffa D, Moggi A, OBJECTIVES:This study aimed to assess the impact of systematic ajmaline provocation testing using high right Mogushi K, Mohan M, Mohapatra SRP, Montani M, Moore CJ, Moraru D, Moreno G, Morriss SR, Mours B, Mow-Lowry precordial leads (RPLs) on the diagnostic yield of Brugada syndrome (BrS) in a large cohort of SADS families. METHODS:Three hundred three SADS families (911 relatives) underwent evaluation with resting electrocardiogram CM, Mueller G, Muir AW, Mukherjee A, Mukherjee D, Mukherjee S, Mukund N, Mullavey A, Munch J, Muñiz EA, Muratore using conventional and high RPLs, echocardiography, exercise, and 24-h electrocardiogram monitor. An ajmaline test M, Murray PG, Napier K, Nardecchia I, Naticchioni L, Nayak RK, Neilson J, Nelemans G, Nelson TJN, Nery M, Neunzert with conventional and high RPLs was undertaken in 670 (74%) relatives without a familial diagnosis after initial evaluation. Further investigations were guided by clinical suspicion. A, Nevin L, Newport JM, Newton G, Ng KKY, Nguyen TT, Nichols D, Nielsen AB, Nissanke S, Nitz A, Noack A, Nocera F, (0) (99) Endnote RESULTS:An inherited cardiac disease was diagnosed in 128 (42%) families and 201 (22%) relatives. BrS was the Nolting D, North C, Nuttall LK, Oberling J, O'Dea GD, Ogin GH, Oh JJ, Oh SH, Ohme F, Okada MA, Oliver M, Oppermann most prevalent diagnosis (n = 85, 28% of families; n = 140, 15% of relatives). Ajmaline testing was required to unmask the BrS in 97% of diagnosed individuals. The use of high RPLs showed a 16% incremental diagnostic yield of ajmaline P, Oram RJ, O'Reilly B, Ormiston R, Ortega LF, O'Shaughnessy R, Ossokine S, Ottaway DJ, Overmier H, Owen BJ, Pace Complexity of autonomic nervous system function in individuals with COPD. testing by diagnosing BrS in an additional 49 families. There were no differences of the characteristics between AE, Page J, Page MA, Pai A, Pai SA, Palamos JR, Palashov O, Palomba C, Pal-Singh A, Pan H, Pan HW, Pang B, Pang individuals and families with a diagnostic pattern in the conventional and the high RPLs. On follow-up, a spontaneous 1.496 PMID 29538539 J Bras Pneumol 2018 Jan-Feb ;44(1) type 1 Brugada pattern and/or clinically significant arrhythmic events developed in 17% (n = 25) of the concealed BrS PTH, Pankow C, Pannarale F, Pant BC, Paoletti F, Paoli A, Papa MA, Parida A, Parker W, Pascucci D, Pasqualetti A, DOI 10.1590/S1806-37562017000000086 cohort. Passaquieti R, Passuello D, Patil M, Patricelli B, Pearlstone BL, Pedraza M, Pedurand R, Pekowsky L, Pele A, Penn S, CONCLUSIONS:Systematic use of ajmaline testing with high RPLs increases substantially the yield of BrS in SADS Vanzella LM, Bernardo AFB, Carvalho TD, Vanderlei FM, Silva AKFD, Vanderlei LCM families. Assessment should be performed in expert centers where patients are counseled appropriately for the Perez CJ, Perreca A, Perri LM, Pfeiffer HP, Phelps M, Piccinni OJ, Pichot M, Piergiovanni F, Pierro V, Pillant G, Pinard L, potential implications of provocation testing. Pinto IM, Pirello M, Pitkin M, Poe M, Poggiani R, Popolizio P, Porter EK, Post A, Powell J, Prasad J, Pratt JWW, Pratten G, OBJECTIVE:To evaluate autonomic modulation in individuals with COPD, compared with healthy controls, via Predoi V, Prestegard T, Prijatelj M, Principe M, Privitera S, Prodi GA, Prokhorov LG, Puncken O, Punturo M, Puppo P, recurrence plots (RPs) and linear heart rate variability (HRV) indices. METHODS:We analyzed data on 74 volunteers, who were divided into two groups: COPD (n = 43) and control (n = 31). Pürrer M, Qi H, Quetschke V, Quintero EA, Quitzow-James R, Raab FJ, Rabeling DS, Radkins H, Raffai P, Raja S, Rajan For calculation of HRV indices, heart rate was measured beat-by-beat during 30 min of supine rest using a heart-rate C, Rajbhandari B, Rakhmanov M, Ramirez KE, Ramos-Buades A, Rapagnani P, Raymond V, Razzano M, Read J, meter. We analyzed linear indices in the time and frequency domains, as well as indices derived from the RPs. RESULTS:In comparison with the control group, the COPD group showed significant increases in the indices derived Regimbau T, Rei L, Reid S, Reitze DH, Ren W, Reyes SD, Ricci F, Ricker PM, Rieger S, Riles K, Rizzo M, Robertson NA, from the RPs, as well as significant reductions in the linear indices in the time and frequency domains. No significant Robie R, Robinet F, Rocchi A, Rolland L, Rollins JG, Roma VJ, Romano JD, Romano R, Romel CL, Romie JH, Rosińska differences were observed in the linear indices in the frequency domains expressed in normalized units or in the low (0) (100) Endnote frequency/high frequency ratio. D, Ross MP, Rowan S, Rüdiger A, Ruggi P, Rutins G, Ryan K, Sachdev S, Sadecki T, Sadeghian L, Sakellariadou M, CONCLUSIONS:Individuals with COPD show a reduction in both sympathetic and parasympathetic activity, associated Salconi L, Saleem M, Salemi F, Samajdar A, Sammut L, Sampson LM, Sanchez EJ, Sanchez LE, Sanchis-Gual N, with decreased complexity of autonomic nervous system function, as identified by RPs, which provide important Incomplete childhood immunization with new and old vaccines and associated complementary information in the detection of autonomic changes in this population. Sandberg V, Sanders JR, Sassolas B, Sathyaprakash BS, Saulson PR, Sauter O, Savage RL, Sawadsky A, Schale P,

factors: BRISA birth cohort, São Luís, Maranhão State, Northeast Brazil.

Scheel M, Scheuer J, Schmidt J, Schmidt P, Schnabel R, Schofield RMS, Schönbeck A, Schreiber E, Schuette D, Schulte 1.133 PMID 29538497 Cad Saude Publica 2018 Mar 12 ;34(3) BW, Schutz BF, Schwalbe SG, Scott J, Scott SM, Seidel E, Sellers D, Sengupta AS, Sentenac D, Sequino V, Sergeev A, DOI 10.1590/0102-311X00041717 Shaddock DA, Shaffer TJ, Shah AA, Shahriar MS, Shaner MB, Shao L, Shapiro B, Shawhan P, Sheperd A, Shoemaker Silva FS, Barbosa YC, Batalha MA, Ribeiro MRC, Simões VMF, Branco MDRFC, Thomaz ÉBAF, Queiroz RCS, Araújo DH, Shoemaker DM, Siellez K, Siemens X, Sieniawska M, Sigg D, Silva AD, Singer LP, Singh A, Singhal A, Sintes AM, WRM, Silva AAMD ­ Slagmolen BJJ, Smith B, Smith JR, Smith RJE, Somala S, Son EJ, Sonnenberg JA, Sorazu B, Sorrentino F, Souradeep T, This study estimated the percentages of incomplete immunization with new vaccines and old vaccines and associated Spencer AP, Srivastava AK, Staats K, Staley A, Steinke M, Steinlechner J, Steinlechner S, Steinmeyer D, Stevenson SP, factors in children 13 to 35 months of age belonging to a birth cohort in São Luís, the capital of Maranhão State, Brazil. The sample was probabilistic, with 3,076 children born in 2010. Information on vaccination was obtained from the Stone R, Stops DJ, Strain KA, Stratta G, Strigin SE, Strunk A, Sturani R, Stuver AL, Summerscales TZ, Sun L, Sunil S, Child's Health Card. The new vaccines, namely those introduced in 2010, were meningococcal C and 10-valent Suresh J, Sutton PJ, Swinkels BL, Szczepańczyk MJ, Tacca M, Tait SC, Talbot C, Talukder D, Tanner DB, Tápai M, pneumococcal, and the old vaccines, or those already on the childhood immunization schedule, were BCG, hepatitis B, human rotavirus, polio, tetravalent (diphtheria, tetanus, pertussis, Haemophilus influenzae b), yellow fever, and triple Taracchini A, Tasson JD, Taylor JA, Taylor R, Tewari SV, Theeg T, Thies F, Thomas EG, Thomas M, Thomas P, Thorne viral (measles, mumps, rubella). The study used hierarchical modeling and Poisson regression with robust variance. KA, Thrane E, Tiwari S, Tiwari V, Tokmakov KV, Toland K, Tonelli M, Tornasi Z, Torres-Forné A, Torrie CI, Töyrä D, Prevalence ratios (PR) and 95% confidence intervals (95%CI) were calculated. Incomplete immunization was higher (0) (100) Endnote with new vaccines (51.1%) than with old vaccines (33.2%). Children 25 to 35 months of age (PR = 1.27; 95%CI: 1.14Travasso F, Traylor G, Trinastic J, Tringali MC, Trozzo L, Tsang KW, Tse M, Tso R, Tsukada L, Tsuna D, Tuyenbayev D, 1.41) and those in economic classes D/E (PR = 1.20; 95%CI: 1.06-1.35) were only significantly associated with new Ueno K, Ugolini D, Unnikrishnan CS, Urban AL, Usman SA, Vahlbruch H, Vajente G, Valdes G, van Bakel N, van vaccines; low maternal schooling (PR = 1.58; 95%CI: 1.21-2.06), unavailability of outpatient and/or hospital care for the Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic child (PR = 1.20; 95%CI: 1.04-1.38), and unavailability of the vaccine in health services (PR: 1.28; 95%CI: 1.12-1.46) Beuzekom M, van den Brand JFJ, Van Den Broeck C, Vander-Hyde DC, van der Schaaf L, van Heijningen JV, van Veggel Tubular Injury Caused by Hemorrhagic Shock in Rats. were only associated with old vaccines. Immunization strategies should consider the vulnerability of older preschoolAA, Vardaro M, Varma V, Vass S, Vasúth M, Vecchio A, Vedovato G, Veitch J, Veitch PJ, Venkateswara K, Venugopalan age children and those belonging to classes D and E, especially when new vaccines are introduced, as well as children PMID 29535870 Pain Res Treat 2018 ;2018 DOI 10.1155/2018/8375746 of mothers with low schooling. Strategies should also address problems with the availability of health services and G, Verkindt D, Vetrano F, Viceré A, Viets AD, Vinciguerra S, Vine DJ, Vinet JY, Vitale S, Vo T, Vocca H, Vorvick C, vaccines. Takaku M, da Silva AC, Iritsu NI, Vianna PTG, Castiglia YMM Vyatchanin SP, Wade AR, Wade LE, Wade M, Walet R, Walker M, Wallace L, Walsh S, Wang G, Wang H, Wang JZ,

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Wang WH, Wang YF, Ward RL, Warner J, Was M, Watchi J, Weaver B, Wei LW, Weinert M, Weinstein AJ, Weiss R, Wen Parecoxib, a selective COX-2 inhibitor, is used to improve analgesia in postoperative procedures. Here we evaluated L, Wessel EK, Weßels P, Westerweck J, Westphal T, Wette K, Whelan JT, Whiting BF, Whittle C, Wilken D, Williams D, whether pretreatment with a single dose of parecoxib affects the function, cell injury, and inflammatory response of the kidney of rats subjected to acute hemorrhage. Inflammatory response was determined according to serum and renal Williams RD, Williamson AR, Willis JL, Willke B, Wimmer MH, Winkler W, Wipf CC, Wittel H, Woan G, Woehler J, Wofford tissue cytokine levels (IL-1, IL-1, IL-6, IL-10, and TNF-). Forty-four adult Wistar rats anesthetized with sevoflurane were J, Wong KWK, Worden J, Wright JL, Wu DS, Wysocki DM, Xiao S, Yamamoto H, Yancey CC, Yang L, Yap MJ, Yazback randomized into four groups: placebo/no hemorrhage (Plc/NH); parecoxib/no hemorrhage (Pcx/NH); placebo/hemorrhage (Plc/H); and parecoxib/hemorrhage (Pcx/H). Pcx groups received a single dose of intravenous M, Yu H, Yu H, Yvert M, Zadrożny A, Zanolin M, Zelenova T, Zendri JP, Zevin M, Zhang L, Zhang M, Zhang T, Zhang parecoxib while Plc groups received a single dose of placebo (isotonic saline). Animals in hemorrhage groups YH, Zhao C, Zhou M, Zhou Z, Zhu SJ, Zhu XJ, Zucker ME, Zweizig J, LIGO Scientific Collaboration and Virgo underwent bleeding of 30% of blood volume. Renal function and renal histology were then evaluated. Plc/H showed the (0) (100) Endnote highest serum levels of cytokines, suggesting that pretreatment with parecoxib reduced the inflammatory response in Collaboration ­ rats subjected to hemorrhage. No difference in tissue cytokine levels between groups was observed. Plc/H showed higher percentage of tubular dilation and degeneration, indicating that parecoxib inhibited tubular injury resulting from The protective arm of the renin-angiotensin system may counteract the intense renal hypoperfusion. Our findings indicate that pretreatment with a single dose of parecoxib reduced the inflammatory inflammatory process in fetuses with posterior urethral valves. response and tubular renal injury without altering renal function in rats undergoing acute hemorrhage. 2.081

PMID 29534877

J Pediatr (Rio J) 2018 Mar 10

DOI 10.1016/j.jped.2018.02.003

Rocha NP, Bastos FM, Vieira ÉLM, Prestes TRR, Silveira KDD, Teixeira MM, Silva ACSE

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OBJECTIVE:Posterior urethral valve is the most common lower urinary tract obstruction in male children. A high percentage of patients with posterior urethral valve evolve to end-stage renal disease. Previous studies showed that cytokines, chemokines, and components of the renin-angiotensin system contribute to the renal damage in obstructive uropathies. The authors recently found that urine samples from fetuses with posterior urethral valve have increased levels of inflammatory molecules. The aim of this study was to measure renin-angiotensin system molecules and to investigate their correlation with previously detected inflammatory markers in the same urine samples of fetuses with posterior urethral valve. METHODS:Urine samples from 24 fetuses with posterior urethral valve were collected and compared to those from 22 (0) (99) Endnote healthy male newborns at the same gestational age (controls). Renin-angiotensin system components levels were measured by enzyme-linked immunosorbent assay. RESULTS:Fetuses with posterior urethral valve presented increased urinary levels of angiotensin (Ang) I, Ang-(1-7) Microplastics in the environment: Challenges in analytical chemistry - A review. and angiotensin-converting enzyme 2 in comparison with controls. ACE levels were significantly reduced and Ang II levels were similar in fetuses with posterior urethral valve in comparison with controls. 4.95 PMID 29534790 Anal. Chim. Acta 2018 Aug 09 ;1017 CONCLUSIONS:Increased urinary levels of angiotensin-converting enzyme 2 and of Ang-(1-7) in fetuses with posterior DOI 10.1016/j.aca.2018.02.043 urethral valve could represent a regulatory response to the intense inflammatory process triggered by posterior urethral valve. Silva AB, Bastos AS, Justino CIL, da Costa JP, Duarte AC, Rocha-Santos TAP

Microplastics can be present in the environment as manufactured microplastics (known as primary microplastics) or resulting from the continuous weathering of plastic litter, which yields progressively smaller plastic fragments (known as secondary microplastics). Herein, we discuss the numerous issues associated with the analysis of microplastics, and to a less extent of nanoplastics, in environmental samples (water, sediments, and biological tissues), from their sampling and sample handling to their identification and quantification. The analytical quality control and quality assurance associated with the validation of analytical methods and use of reference materials for the quantification of microplastics are also discussed, as well as the current challenges within this field of research and possible routes to overcome such limitations.

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