MARKET SURVEY CUM DETAILED TECHNO ECONOMIC FEASIBILITY REPORT (PROJECT FEASIBILITY REPORT) ON
AYURVEDIC MEDICINES Published Date: 23 March 2014 For Latest Report – Visit www.eiriindia.org
INDENTIFICATION & EVALUATION DIVISION FOR HI-TECH PROJECTS
EIRI CONSULTANTS & ENGINEERS * REGD. OFFICE * 4449, NAI SARAK, MAIN ROAD, NEAR CHANDNI CHOWK, DELHI - 11 00 06. (INDIA) (BETWEEN MARWARI KATRA AND ROSHAN PURA), PH : 91-11-23918117, 23916431, 45120361, 64727385, 23947058
E-Mail :
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This project report has been prepared on the basis of information available with M/S. ENGINEERS INDIA RESEARCH INSTITUTE. The intention here is to provide preliminary information to the prospective entrepreneur. Prior to making a firm decision for investment in the project the entrepreneur must verify the various feasibility aspects together along with the addresses for the procurement of plant & machinery and raw materials independently. The information supplied in this report is obtained from the reliable sources but it is not guaranteed and the money once paid will not be refunded back in any case. Claims for incomprehensiveness of the project report will not be entertained and no legal action in this regard would be entertained in any case (Subject to Delhi Jurisdiction only). Any matter relating to our standard points covered in the report may be modified with in 5 days time only from the date of purchase. ENGINEERS INDIA RESEARCH INSTITUTE, 4449 NAI SARAK, DELHI-110006
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] (J.C. 442) CONTENTS
Introduction Uses and application B.I.S specifications Market survey Some present manufacturers of ayurvedic medicines for diabetes Formulation of liquid ayurvedic medicine for diabetes Formulation of ayurvedic granules for diabetes (madhuhari type) Formulation of ayurvedic capsules for diabetes (deebonil type) Formulation of ayurvedic tablets for diabetes (dybit-32 type) Manufacturing process for liquid ayurvedic medicine for diabetes Process flow diagram for the manufacture of liquid ayurvedic medicine for diabetes Plant layout for liquid ayurvedic medicine for diabetes General detailed aspects of liquid extract of ayurvedic medicine production by distillation Manufacturing process of ayurvedic tablets for diabetes Process flow diagram for the manufacture of ayurvedic tablets for diabetes Manufacturing process of ayurvedic capsules for diabetes Process flow diagram for the manufacture of ayurvedic capsules for diabetes Manufacturing process of ayurvedic granules for diabetes Plant layout of ayurvedic medicine for diabetes (granules, capasules and tablets) Suppliers of plant and machinery Suppliers of packaging materials Liquid ayurvedic medicine for diabetes Raw materials calculations for ayurvedic medicines for diabetes (granules, capsules & tablets)
5 8 9 11 18 19 20 21 22 24 28 30 31 45 51 52 55 56 58 59 66 68 69
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APPENDIX – A : 1. Cost Of Plant Economics 2. Land & Building 3. Plant And Machinery 4. Fixed Capital Investment 5. Raw Material 6. Salary And Wages 7. Utilities And Overheads 8. Total Working Capital 9. Cost Of Production 10. Profitability Analysis 11. Break Even Point 12. Resources Of Finance 13. Interest Chart 14. Depreciation Chart 15. Cash Flow Statment 16. Projected Balance Sheet
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AYURVEDIC MEDICINES INTRODUCTION Ayurvedic system of medicine is as old as the Vedic age. Now–a–days people give preference to the Ayurvedic medicines as the allopathic medicines are costlier and have side effects. Ayurvedic medicines are based on plants, animals extract and minerals both in single ingredient drugs and compound formulations, however, Ayurveda does not rule out any substances from being used as a potential source of medicine. Ayurvedic compound formulations are mainly divided into two groups viz. (1) Kasthausadhi (predominantly plant drugs) and (2). Rasausadhi (predominantly metals and minerals). There are several categories of Kasthausadhi formulations such as Asavaristra, Avleha, Grafa Churena, Taila etc. and of Rasausadhis such as Bhasma, Pisti, Lauha, Kapibadkva, Rasayana etc. The Ayurvedic drugs are derived from vegetable sources from the various parts of the plant like root, leaf, flower, fruit extrude or plant as a whole. There are about 21 varieties of compound formulations in which some of the single drugs of animal origin (52 Nos). Mineral origin (55 Nos.) and plant origin (351 Nos.) are used. There details of the single drugs and other particulars can be had from the Ayurvedic formulary of India, published by Govt. of India, Ministry of Health and Family Welfare. Ayurvedic system has its origin in antiquity in our country which has been dedicated to the cure of innumerable ailments. It has been most indelible system for treatment which invariably stood to the test of time. India abounds in medicinal plants and more than 75% of the vegetable drugs included in pharmacopias are available in the country.
Ayurvedic medicines have been derived from variegated medicinal plants. Forests abound in various medical plants from which various herbs are
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collected and herbal/ayurvedic medicines are made out of than Ayurveda, Unani, Siddha, Emchi (Tibetan) and Prakrtika Cikitsa (Naturopathy) are the various traditional systems of medicine still prevalent in India. The word `Ayurveda' is composed of two Sanskrit terms, viz., `ayus' meaning `life' and `veda' meaning the `knowledge' and taken together, it means the "Science of Life". However, in a limited sense, it is always used to imply "the Science of Medicine". Charaka has defined ayurveda as the "Science through the help of which one can obtain knowledge about the useful and harmful types of life (hita and ahita ayus), happy and miserable types of life, things which are useful and harmful for such types of life, the span of life as well as the very nature of life. There has been a tremendous work on Ayurveda viz. Astaga Hardaya which deals with drugs, their intricate composition and pharmacologial action. This system has a great efficacy in eradicating ailments from their root cause, though the action of Ayurvedic medicines may be slower. DIABETES MELLITUS It is a chronic disorder of carbohydrate metabolism due to inadequate endogenous production or utilization of insulin and characterized by hyperglycemia, glycosuria, polyuria, polydipsia, polyphagia, pruritus debility and loss of weight. As for the etiological consideration, damage of the insulin-producing cells of the islets of longer hour is responsible for most cases of diabeties mellitus. Continued hyperglycemia may produce such permanent damage reducing the endogenous output of insulin. The Ayurveidc medicine for Diabetes in India is available in the form of Granules, tablets and Capsules. Among the ones prevelant, mention may be made of madhuhari granules, Deebonil capsules, Dybit-32 Tablets.
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Though in the modern world of hurry and scurry where people have no time to stand and stare. They look for such medication which shows prompt action. This they find in allopathic medication. But, however, there are lot of side effects of Allopatic medicines. That is precisely why people are reverting back to Herbal/Ayurvedic system of treatment which has no side effects. The basically accounts for the prominence of Ayurvedic system of medicines. As a consequence the demand of Ayurvedic/Herbal products is increasing day by day. At present there exists a great demand supply gap, therefore in order to bridge this gap this is imperative need for more new units come up the field.
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USES AND APPLICATION Ayurvedic medicine for Diabetes is used for the treatment of Diabetes, by controlling the blood sugar level.
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B.I.S. SPECIFICATIONS There are no Indian Standard prescribed products viz. Ayurvedic medicine for Diabetes.
for
manufacturing Ayurvedic
For more Information contact at: Headquarters: Manak Bhavan, 9 Bahadur Shah Zafar Marg, New Delhi-110 002 91 11 23238821,23233375,23239402 91 23238821, 23239399 (Fax)
[email protected] Institution. Sr.No. 01.
02.
03.
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Sales Outlets Address Director (Sales) Manak Bhawan, 9, Bahadur Shah Zafar Marg New Delhi-110 002 Western Regional Office Manakalaya, Plot No. E-9, MIDC, Road No. 8, Behind Telephone Exchange, Andheri (East), Mumbai-400 093 Eastern Regional Office 5, Chowringhee Approach P.O. Princep Street, Kolkata-700 012 Northern Regional Office SCO 335-336, Sector 34-A Chandigarh-160 022 Southern Regional Office C.I.T. Campus, IV Cross Road Chennai-600 013
Telephone No/Fax/e-mail 91-1123238821,23233375,23239402 91-23238821, 23239399(Fax) Phone 022-28329295 Fax 28374231 Email:
[email protected]
033-232053243 91-33-23377459(Fax)
[email protected] 91-0172 2665512 91-0172 2602025 (Fax) 910172-2609285, 2664750,2624136(PBX)
[email protected] 91-044-22542315, 22541584,22541470 91-044-22541087 (Fax)
[email protected]
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NOTE :- The use of the ISI Certification Mark is governed by the provisions of the Indian Standards Institution (Certification Marks) Act and the Rules and Regulations made thereunder. The ISI Mark on products covered by an Indian Standard conveys the assurance that they have been produced to comply with the requirements of that standard under a well-defined system of inspection, testing and quality control which is devised and supervised by ISI and operated by the producer. ISI marked products are also continuously checked by ISI for conformity to that standard as a further safeguard. Details of conditions under which a licence for the use of the ISI Certification Mark may be granted to manufacturers or processors, may be obtained from the Indian Standards Institution.
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MARKET SURVEY
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Thirdly firms need to spend time on patient education, Letting both Indian and global consumers know the benefits of using Ayurveda. I do feel that many young Indians associate Ayurveda with the older vision of India and do not want to adopt it. During a recent trip to a Natu Marandu (Traditional Ayurveda )Shop in Chennai I saw that most customers were in the age group of 50 plus. As a matter of fact many in my peer group found it funny that I was buying traditional medicine despite being trained in Allopathy. In conclusion I feel the future of Ayurveda is in our hands. Firms need to get smart about branding, manufacturing and patient education for us to get our due in the global market place.
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SOME PRESENT MANUFACTURERS OF AYURVEDIC MEDICINES FOR DIABETES
1) Madhuhari Granules (Net wt. 100 gms Granules per pack) Shiv Herbal Research Lab Ltd. Plot No. S-19 M.I.D.C. Hingna Road Nagpur-26
2) Deebonil Capsules (40 Capsules per pack) Manufactured by Prabhat Ayurvedic Pharmacy ASR 2171/5, Tilak Bazar, Khari Baoli, Delhi
3) Dybit-32 Tablets (100 Tablets (wt. = 50 gms) per pack) Shree Hans Ayurvedic Pharma Shree Prem Nagar Ashram P.O. Jwalapur, Haridwar-249407 Phone: 7503, 6345
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FORMULATION OF LIQUID AYURVEDIC MEDICINE FOR DIABETES COMPOSITION 1. Gurmar
45%
2. Vijay Sar
25%
3. Bilva Patra
10%
4. Karela Seeds
10%
5. Jamun Guthi
10%
Bhavina, Karela Ras, Pan Ras, Methi Ras, etc.
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FORMULATION OF AYURVEDIC GRANULES FOR DIABETES (MADHUHARI TYPE)
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FORMULATION OF AYURVEDIC CAPSULES FOR DIABETES (DEEBONIL TYPE)
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FORMULATION OF AYURVEDIC TABLETS FOR DIABETES (DYBIT-32 TYPE)
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Dosage of Ayurvedic Medicine for Diabetes 1) Madhuhari Granules 1/2 Tab Granules twice a day 2) Deebonil Capsules 1 Cap twice a day before meals with warm milk or as directed. 3) Dybit-32 Tablets 2 Tablets two or three times a day 1 Tab twice a day
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MANUFACTURING PROCESS FOR LIQUID AYURVEDIC MEDICINE FOR DIABETES
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The different ingredients are taken in requisite quantities. Among these ingredients, however, those of primal signifacance are Gumar available as leaves and Vijay Sar as wood. To prepere the liquid extract (in concentrated form), the main methodology takes recourse to steam distillation technique. However, the process of extraction for essential constituents in liquid form from these Ayurvedic herbs comprises the following steps (If herbs are available already in cleaned form, that is well and good. In case of adhering contaminents, cleaning, etc. is done) 1. Cleaning of the botanical herbs viz. leaves, wood, seeds, etc. 2. Washing 3. Drying 4. Disintegration into small chips 5. Steam distillation 6. Bottling of the liquid extract
1.
CLEANING
These herbs, if accompanied with adhering contaminations, are subjected to cleaning to remove the impurities. 2.
WASHING
The herbs are then washed with water to wash off the adhering dust or any other impurities. 3.
DRYING
Then these herbs from which liquid is extracted is subjected to drying.
to
be drawn, are
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4.
DISINTEGRATION (COMMINUTION)
Prior to distillation, the herbs must be disintegrated to some extent. This disintegration process commonly terned `comminution' results in exposing directly as many oil glands as is practically possible. It always reduces the thickness of the material through which diffusion must occur, greatly increasing the rate or speed of vaporization and distillation of essential oils as extract Seeds must be thoroughly washed in order to rupture as many of the cell walls as possible, to render the essential oil extract accessible to the passing steam. Woody materials should be cut into short lengths in order to expose a great number or oil glands. Vijay Sar (wood) is disintegrated by sawing into small pieces (chips) or chipped mechanically the woody material should be cut into short lengths in order to expose a great number of glands. Karela seeds can be best crushed by passing then through smooth rolls. These rolls should be arranged so that the distance between then can be varied. The width of this space will determine the extent of crushing obtained. Each roll should also be equipped with a scraping device, called a "doctor blade", which serves to keep it free of adhering crushed material.
In general, roots, stalks, guthi (viz. jamun guthi) can be best handled in a hay or ensilage cutter, or similar device, However, leaves and thin and nonfibrous parts of the plant viz. Gurmar leaves, silva patra can be distilled without comminution. The cell walls in these parts are in most cases sufficiently thin and permeable to permit rapid removal of the essential liquid extract. 5.
STEAM DISTILLATION
Steam distillation process is carried out with steam. Cleaned Gurmar leaves, Vijay Sar wood chips, Bilva patra, karela seeds and jamun guthi are sepaartely charged (not-collectively) into the distillation still filled with water and steam distillation operation is carried out for the purpose of collecting the liquid Ayurvedic extract separate distillation process for each of these herbs is based on the different vopor processes of the individual constituents which are ultimately condensed to obtain the liquid extract.
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The distillation stills employed in industry are of copper, tin-lined copper or stainless steel and of capacity in accordance with the amount of material to be handled. They are provided with condensers of various sorts, tubular one being the aqueous one. A better procedure is to constract the still with a perforated false plate lying just above the bottom. Underneath this false bottom are steam coils, bath closed and perforated. In operating these stills, the charge is heated with steam in both the open and closed pipes, thus affecting economical steam distillation. The individual liquid extract collected by separately distilling the herbs viz. Gurmar, Vijay Sar, Silva patra, Karela seeds & Jamun guthi in the condensing vessel being heavier than water sinks to the bottom and the water cover prevents loss by evaporation the aqueous layer in the condensate frequently carries in solution, valuable constituents, and is consequently pumped back into the still to supply some of the necessary water. The indvidual condensate liquid extracts collected separately by distillation are then mixed together to prepare the final liquid extract (concentrated) as liquid Ayurvedic medicine.
QUALITY TESTING Quality testing of the product i.e. liquid extract is done to ensure that it is of requisite quality. BOTTLING Then, this is filled in suitable containers and dispatched for marketing. NOTE The concentrated extract may be diluted to desire degree and accordingly selling price will vary i.e. reduced.
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PROCESS FLOW DIAGRAM FOR THE MANUFACTURE OF LIQUID AYURVEDIC MEDICINE FOR DIABETES
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PLANT LAYOUT FOR LIQUID AYURVEDIC MEDICINE FOR DIABETES
TOTAL LAND AREA = 500 SQ.MT.
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GENERAL DETAILED ASPECTS OF LIQUID EXTRACT OF AYURVEDIC MEDICINE PRODUCTION BY DISTILLATION In general, the term `distillation' applies to vaporization process in which the vapour evolved is recovered, usually by condensation. The main purpose of distillation is either the separation of volatile components from nonvolatile materials or the separation of mixture of volatile components. The separation of volatile components from non-volatile materials is carried out by simple distillation in which material is placed in a still and heated and the vapour removed and condensed. This process is frequently used for high boiling organic compounds, to prevent thermal degradation of the product, with addition of steam or water, termed as water, steam/water, steam distillation. The quality of essential oil produced is, of course, dependent on the plant material but also the general design and operation of distillation equipment. the distillation unit plays important role in the production of essential oils. It is the controlling link between these oils in their natural state within the tissues of the plant and their liberated form which are utilized for many purposes. The yields and qualities of commercial essential oils depend on the correct design and operation of the still. Principle Steam distillation is a simple vaporization achieved by letting in live steam directly through the charge. The relation between the quantity of steam and that of volatile constituent is given by the equation: Ps Ls -------- = -------P LT Where Ps is the partial pressure of the steam. P is total pressure of the system Ls is moles of steam issuing from the charge LT is total moles of vapour generated (i.e., steam + volatile oil).
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In order to isolate and essential oil from an aromatic plant, the material is packed into a still, a sufficient quantity of water is added and brought to a boil, or live steam is injected into the plant charge. Due to the influence of hot water and steam, the essential oil will be freed from the oil glands in the plant tissue. The vapour mixture of water and oil is condensed by indirect cooling with water. From the condenser, distillate flows into a separator, where oil separates automatically from the distillate water. Mechanism of Distillation Hydrodistillation of plant involves following main physico-chemical process: i) Hydrodiffusion ii) Hydrolysis iii) Decomposition by heat.
(i) Hydrodiffusion Diffusion of essential oil and hot water through the plant membranes is known as hydrodiffusion. In steam distillation, the steam does not actually penetrate the dry cell membranes. Therefore, dry plant material can be exhausted with dry steam only when all the volatile oil has been freed from the oil bearing cells by first thorough comminution of the plants. But, when the plant material is soaked with water, exchange of vapours within the tissue is based on their permeability while in swollen condition. It has been studied that volatile oils are almost impermeable through membranes of plant cells. Therefore, in the actual process, at the temperature of boiling water a part of volatile oil dissolves in the water present within the glands, and this oil in water solution permeates, by osmosis, through swollen membranes and finally reaches the outer surface, where the oil is vaporized by passing steam. Another aspect of hydrodiffusion is that the speed of oil vaporization is not influenced by the volatility of oil components but by their degree of solubility in water. therefore, the higher boiling but more water soluble constituents of an oil in the plant tissue, distill before the lower boiling but less water soluble constituents. Since hydrodiffusion rates are slow, distillation of uncomminuted material takes longer time than comminuted.
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Hydrolysis
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Besides, being a time dependent reaction, the extent to which hydrolysis proceeds, depends upon the time of contact between oil and water. This is one of the disadvantages of water distillation. (iii) Effect of heat Almost all constituents of essential oils are unstable at high temperatures. To obtain best quality of oil, it is necessary that the distillation is resorted to low temperatures. The temperature in steam distillation is determined entirely by the operating pressure, whereas in case of water distillation and water steam distillation operating pressure is usually atmospheric. All the above described there effects, i.e. hydrodiffusion, hydrolysis and thermal decomposition occur simultaneously and they affect one another. The rate of diffusion usually increases by higher temperatures and so also the solubility of essential oil in water. The same is true for rate and extent of hydrolysis. However, it has been observed that by (1) maintaining of low feasible temperature; (2) use of as little water as possible in case of steam distillation; and (3) through comminution of plant material before distillation and uniform packing, it is possible to obtain better yield and quality of oils.
Types of Distillation and Their Techniques There are three types of hydrodistillation techniques for isolating essential oils from plant materials. (1) Water distillation (2) Water and steam distillation (3) Direct steam distillation 1)
Water Distillation
In this method, the material is completely immersed in water and water is boiled by applying heat either by direct fire or steam jacket or closed steam coil or open steam coil. the main characteristic of this process is that there is direct contact between boiling water and plant material.
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Adequate precautions are necessary to prevent the charge from overheating when the still is heated by direct fire. When a steam jacket or closed steam coils are used, there is less danger of overheating and with open steam coils this danger is avoided. But with open steam, care must be taken to prevent accumulation of condensed water within the still. Therefore, still should be well insulated. During water distillation, all parts of the plant charge must be kept in motion by boiling water and this is possible when the distillation material is charged loosely and remains loose in the boiling water. For this reason only, water distillation possesses one distinct advantage that it permits processing of very finely powdered material or plant parts which by contact with live steam would easily form lumps through which the steam connot penetrate. other practical advantages of water distillation still a5e that these are cheap and easy to construct and suitable for field operation. These are still quite widely used with portable equipment in may countries. The main disadvantage of water distillation is that complete extraction of material is not possible. Besides, certain esters are partly hydrolysed and sensitive substances like aldehydes tend to polymerize. Water distillation requires a greater number of still, more space and more fuel. It demands considerable experience and familiarity with the method. The high boiling and somewhat water soluble oil constituents cannot be completely vaporized or they require large quantities of steam. Thus the process becomes uneconomical. For these reasons, water distillation is used only in case where the plant material by its very nature cannot be processed by water and steam distillation or by direct steam distillation. (2) Water and Steam Distillation In this method, the plant material is supported on a perforated grid or screen inserted some distance above the bottom of still. The lower part of the still is filled with water, to a level somewhat below this grid. The water is heated either by open fire, or by jacket steam, or steam coil or open steam. The saturated low pressure steam rises through plant material. The typical characteristics of this method are that the steam is always fully saturated, wet and never superheater and that the plant material is in contact with steam only and not with boiling water. This method is generally employed by small producers using portable distillation equipment that can be moved from field to field, following the harvest. The smaller units are heated by direct fire and the larger ones by steam jacket or coil or open steam. When using direct fire, care is taken to ensure that only
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bottom of the still is heated, otherwise one one of the major advantage of this method over water distillation (no overheating of charge) will be lost. Preparation of the plant material is also important factor in this method. Since steam contacts the material only by rising through it, the plant charge must be so dispersed that all parts of it are uniformly contacted by steam for obtaining high yields. Compared with water distillation, water and steam distillation has many advantages, i.e., the decomposition of the oil is less, it requires less fuel, less time and yields more oil. If, however, a plant material (for instance, rose or orange blossoms) forms lumps under the influence of steam, the steam cannot penetrate the charge and reach every plant material. In such a case water distillation is opted.
One great disadvantage of water and steam distillation is that as a result of the low pressure of the rising steam, oils, of high boiling range require large quantities of steam for complete vaporization-hence long hours of distillation. Water beneath the grid is usually discarded after the distillation is complete because water soluble materials of the plant charge accumulate in the water and they decompose during subsequent distillation imparting an objectionable note to the essential oil. (3) Steam Distillation at Reduced Pressure This method is used when volatile oil is likely to decompose at high pressure, especially for oils containing esters. However, it should be noted that in case of distillation at reduced pressure the ratio of oil to water in the distillate is less than when some products are distilled at atmospheric pressure, because any lowering in the external pressure reduces the vapour pressure of all high boiling compounds relatively much more than that of water. Besides, at reduced pressure, because of lowering in temperature, effective log mean temperature between water and vapours will reduce and considerable oil losses may be expected by evaporation. In order to achieve high rage of distillation at reduced pressure the empty space above the liquid in the vacuum still should be kept sufficiently large to
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permit the still content to boil without foaming into the condenser (this is particularly so in respect of hydrodistillation). Besides, the condenser surface must be larger, estimated to be 4 to 5 times than that required fro distillation at atmospheric pressure, because of high volumetric rates and low temperature difference. Distillation at high pressure Pressure in the still can be increased by inserting a throttling valve in the vapour line connecting the still and condenser. Steam distillation at high pressure is useful for certain purposes, for instances, for the hydrolysis of ester if so desired. There is another advantage, i.e., relative to steam pressure, the vapour pressure of higher boiling oil constituents increases more as the temperature rises resulting in better oil to water ratio in the distillate. However, from this viewpoint distillation with superheated steam is better because it vaporizes more oil without necessitating the high pressure of the former method, but hydrodiffusion in this case has be maintained by injecting wet steam, intermittently to obtain good yield. Superheated steam distillation In this method saturated steam may be superheated within the still by means of closed coils or jacket or outside the still in boiler. Usually, the stills employed for distillation by superheated steam are constructed high with small diameter, well insulated and provided with jacket. this method is with mostly used for distilling all high boiling and chemically stable compounds and with the plants containing high moisture (60 -80%), because hydrodiffusion is automatically maintained by the presence of water in the plant material. The operation can be carried out with superheated steam at reduced pressure as well. By this methods, it is possible to regulate the temperature of the oil vapours at will. According to degree of superheat, rise in vapour temperature will result which means a more favourable ratio of oil in the distillate than is the case when oil is merely steam distilled at reduced pressure without superheating. Injection of wet steam intermittently is necessary to maintain hydrodiffusion conditions.
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Equipment The equipment required for carrying out distillation of plant materials depends upon the size of the operation and the type of distillation to be used. But, however, in industrial practice, the following items are necessary: i) ii) iii) iv) v)
Still Condenser Separator Steam generator Labour saving devices
(i) Still:- This serves primarily as a container for the plant material where steam contacts the plant material and vaporizes the essential oil from the plant material. It is usually cylindrical, vertical tank equipped with a removable cover which can be clamped upon the cylindrical section. On or near the top of the cylindrical section a pipe is attached for leading the vapours to the condenser. Nearby the bottom, there is a grid or false bottom on which the material rests and live steam is introduced through a steam line, usually a perforated coil below false bottom. The cylindrical section is slightly tapered to facilitate easy discharging of material manually or mechanically. The bottom of the still is provided with a drain valve so that any water condensing within the charge can be drawn off in the course of distillation. Insulation:- The still, including the top should be well insulated to conserve heat. If insulation is neglected, excessive steam condensation occurs resulting in bumping of particles, higher steam consumption, prolonged distillation and inferior yield of oil. Usually all heated sections including steam lines are well insultated. (ii) Condenser:- This serves to convert the steam and accompanying oil vapours into liquid. This requires the removal of an amount of heat equivalent to the heat of vaporization of the vapours plus steam, and cooling the distillate to near ambient temperatures. The rate which heat will be removed from the vapours is expressed by:
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Q = UA/_\tlm Where
Q is heat removed per unit time U is over all heat transfer coefficient A is area of heat transfer /_\ tlm is long mean temperature difference between cooling medium and vapours.
Condenser design is important, the most efficient type being the multi-tubular condenser. It is compact, does not develop back pressure and permits higher distillation rate than the single coil or pipe condenser as U valves are much higher. Another point of importance in favour of shell and tube condenser is that when a distillation is carried out by cohobation, the condenser being compact, enables the distillates to be returned easily to the still from the oil separator without recourse to a high still head connection to the condenser. (iii) Oil Separator:- Its function is to achieve a quick and complete separation of the oil from condensed water. Volatile oil and water are mutually insoluble. Because of the difference in their specific gravities two liquids form two separate layers. Since the total volume of water condensed is always greater than the quantity of oil, water is removed continuously. Various types of designs for separator area in practice and are designed on the basis of specific gravities and average flow rates. Some of the prominent types of oil separators that are commonly used are discussed below: (a) For oils lighter than water:- A smooth flow of condensate is assured by inserting a long stemmed funnel, the end turning upward. The distillate streaming from the condenser thus flows first through the funnel and oil droplets rise slowly towards the oil layer where they merge. Water is continuously removed through a siphon pipe. (b) For oils heavier than water:- In this type flow through the funnel steam ending in the middle there is no upward bend. The oil droplets which slowly to the bottom and get collected there. continuously from the top.
also condensate is allowed to of the separator chamber but are heavier than water sink Water is allowed to flow
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When some of the essential oil fractions are lighter than water and some heavier, the separator is then so designed that both the heavy and light parts are collected separately. The general arrangement is shown in Fig 2.(a). In such cases, a cylindrical or rectangular chamber is divided into two parts by partition which ends a few inches from the bottom of the vessel. the condensate flows into the first chamber, oil lighter than water collects in the upper part of the first chamber and flows out from there, while oil heavier than water sinks to the bottom of the two chambers and is drawn off from there. In some cases when oil and water do not separate immediately in the oil separator, especially when the difference between specific gravities of water and oil is slight, one operational precaution must be taken into consideration that the condensate does not flow too rapidly and disturb the oil water layer. In such cases the chamber must be large enough to allow enough residence time for oil droplets. The stems of the inlet funnel and water outlet are bent upwards as shown in Fig 2(a). The performance of the separator can also be improved by providing more compartments as shown in Fig. 2(b) and bottom of the chamber partitions may be tapered to ensure quick and complete withdrawal of heavy oil. The same arrangement can be obtained by connecting serially several separators usually in the form of step like cascades. The continuous withdrawal of oil is based on the difference in surface tensions of oil and water. But this type is useful for small flow rates, therefore, not of much use in industrial large scale stills. The effect of condensate temperature:- When the oil specific gravity is slightly less than water, condensate should be allowed to flow hot through the separator, because with rising temperature the specific gravity of oil decreases relatively more than that of water. The resulting greater differential in the specific gravity between oil and water at elevated temperature causes the two layers to separate more rapidly. But in case of the specific gravity f oil at room temperature being slightly higher than water, the condensate should run as cold as possible. Any increase in the temperature would further decrease the already small differential between the specific gravity of the oil and water. Steam generator:- Steam is most useful heating medium in process plant. In the initial stages of steam generation, water is evaporated and is in equilibrium with the boiling water at the pressure of generation. This water vapour is called saturated steam and any lowering of temperature or increasing of pressure will cause condensation to begin. High moisture in steam is undesirable, therefore, saturated steam passes through a heat exchanger called super-heater, which is located in a hot zone of the furnace. The steam is heated above its
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saturation temperature, so that it will be sufficiently dry to provide moisturefree steam.
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Solid fuels such as coal are all fed to the furnace manually or by mechanical means. These include the following: a) b) c) d)
Retort Stoker Spreader stoker Travelling grate Pulverizer
: Introduces fuel beneath the bed. : Distributes coal above burning bed. : Pulverized coal is mixed with air and distributed vertically/ horizontally into the combustion zone.
Liquid fuels must be atomized so that drops of fuel will burn as completely as possible. A number of different types of burners can be obtained using either steam or mechanical atomization. In the first type, stem flows through nozzle with oil causing atomization. In the second type atomization is produced by forcing oil at high pressure through a spray type nozzle. Types of boilers:- Boilers consist of surfaces through which heat is transferred and are designed for circulation and separation of water and steam. They may be classified generally as fire tube or water tube types. Fire tube boilers:- I fire tube boilers, water circulation, steam formation and separation all take place in a large horizontal drum situated above the furnace floor so that it will receive both radiant and convective heat. Hot gases pass over the drum and then through the drum . Feed water is maintained above the top row of tubes. Fire tube boilers are low in initial cost and because of the large capacity of the drum operate will under fluctuating loads common to process plants. They are, however, limited to low capacities and pressure. Water tube boilers:- In water tube boilers, water and steam flow inside the tubes and hot gases are directed across the tubes by baffles. They may be classified as straight tube and bent tube boilers. All large high pressure boilers are water tube types. Since the pressure is on the inside of the tubes instead of outside, the given thickness and diameter of the tube can withstand a higher pressure.
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Standardized and packaged steam generators:- the boiler industry has standardized construction of many boiler styles in recent past. Standardized boilers are obtainable as packaged units which are completely assembled units that are ready fro installation. Fire tube units are built for capacities from 200 to 8000 kg/hr of saturated steam and pressure form 10 to 600 psig. Water tube units produce twice as much steam and upto 900 psig. Packaged units are automatically controlled and are designed to operate efficiently both at low and high capacities. The locomotive type (oil fed) boiler is sometimes used for temporary installation in process plants. (v) Labour saving devices:- In industrial large scale steam distillation practice, large-sized distillation stills in series are common. Labour and time requirement for charging and discharging the stills are very high if done manually. Therefore, in order to save both time and labour, the methods, of charging and discharging are mechanized. This is accomplished by installing a EOT Crane with suitable devices for lifting the top of the still and material. Automatic charging is done by placing the still sin such a position that truck or cart can directly empty the material in the still. The false bottom or grid supporting the plant material, is usually circular in shape. Chains or heavy wires attached to three or four equally spaced points around the circumference of the grid, serve as handles so that the plant charge can be easily removed after distillation simply by lifting the grid. If charges in excess of one quintal are to be distilled, it will be convenient to use more than one such section, placing a new one on top of the first layer and continuing the charge above this section. This arrangement prevents excessive packing, assures better steam distribution, and facilitates discharging the spent material. Coarse and specifically lighter material can be packed higher, whereas fine and heavier material should not exceed a certain height. Material of Construction In the past copper was main choice for the still body, but mild steel and aluminium are used in many cases. There is increasing use of stainless steel as it offers many advantages, because it is non-reactive to the oils and has good mechanical strength. When mild steel constructed still is used, the condenser vapour lines and separator are constructed of aluminium for economy and maintaining the quality of oil.
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Wood and concrete have been used in some instances, but because of their absorption characteristics, are suitable for distilling only one type of material. The use of plastic materials for lining purposes is not allowed. Where gaskets are necessary and come in contact with the oils, they should be constructed from compressed asbestos fibre. Rubber should never be used as packing material as it tends to be dissolved by essential oils. Optimization It is quite obvious that steam distillation parameters greatly influence the total cost of production therefore, for economic production on large scale it is always necessary to determine the optimum operating conditions so that the total cost of production per unit weight or volume of essential oil is minimum. The main parameters that should be considered before commercial scale production of essential oil by steam distillation are: (a) (b) (c) (d) (e)
Batch size Comminution of plant materials and handling Steam pressure and its saturation Steam injection rate Time of distillation.
For any particular type of plant material, the optimum values of the parameters can be determined only by experimentation and economic considerations; in essence, series of experiments are to be conducted by keeping all but one parameter constant and then studying the effect on overall cost of production. Detailed investigations on optimization studies on steam distillation of various plant materials like Mentha piperita, Eucalyptus citriodora, saussurea lappa roots, Himalayan Cedrus deodara wood, are available in literature and are discussed here in brief. On pilot plant scale, studies were conducted by Narasimha et al. on steam distillation of M.piperita and E.citriodora by keeping batch size and steam pressure constant and it was found that at the steam injection rate of 1.2 kg/min for M. p;iperita (80kg/batch) and 1.3 kg/min for E.citriodora (175 kg/batch) and operation time of 45 minutes (which does not include charging, preheating and discharging time, etc.), the cost of production per unit weight of oil was found to be minimum. At this steam injection rate, cost of production for the total oil produced at the end of each interval was calculated. We get optimum distillation time. Similarly, for E. citriodora the percentage recovery vs time at different steam rates. At 1.3 kg/min percentage recovery is maximum. At this steam injection rate optimum distillation time can be graphically evaluated.
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MANUFACTURING PROCESS OF AYURVEDIC TABLETS FOR DIABETES
As per the formulation specified under Ayurvedic Tablets for Diabetes, various ingredients are taken in requisite quantities.
The process consists of the following operations : 1. Formulation 2. Mixing and milling the dry extracts 3. Granulation 4. Drying 5. Lubrication 6. Compression 7. Coating (if required)
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1.
FORMULATION
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2.
MIXING AND MILLING THE DRY INGREDIENTS
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3.
GRANULATION
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GRANULATION BY SLUGGING In this method the ingredients are thoroughly in the form of powder and then they are compressed into crude tablets or slugs. Now these slugs are ground down to the size of the granules desired, then these granules are recompressed into the final product. The machine known as 'Oscillating Granulator' is used for breaking the slugs into uniform granulation, and the machine used for initial compression of a powder is a rotary type tabulating machine. Oscillating granulator machine has a rotor at the bottom of the hopper which oscillates back and forth, breaking the slugs, and forcing them through a special steel screen of the proper mesh. In tabulating machine the powder is fed through a satisfactory feeding device into die cavities which pass beneath it by means of a revolving table. 4.
DRYING
This method, described above, requires no granulating agent, since the materials are always available in granular form. It is the result of a minor vacuum created in the pores of the tablets by the evaporation of the moisture at the surface. The granulations should be dehydrated before they are compressed into the tablet form or the moisture imprisoned within melt cause the tablet to crack. The drying equipments must be flexible to a cause idle conditions to suit the product, because of the foil, all materials dry at deferent speeds, thus requiring that under ordinary factory conditions where a variety of products will be made. Normally dryer used for tablet making is designed to circulate dry air through the drying closet. Dry extracts are prepared in granular form by manufacturers. Dry extracts of cascarasa grade, for example, is used almost exclusively in tablet form.
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5.
LUBRICATION
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6.
COMPRESSION
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ADJUSTMENT OF THE MACHINE For Capacity 1. The lower punch is set at a low position by moving the capacity regulating screw upwards and turning the driving wheel until punch is at its lowest point. 2. A weighed quantity of granules is placed in the die. 3. The lower punch is then moved upwards by turning the driving wheel until the surface of the granules is level with surface of die. 4. The lower punch is now in its correct chopped position and is fixed by moving the capacity regulating screw downwards until it presses against the base of the machine.
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Following care should be taken while compressing of tablets is being carried out : 1. Ensure proper cohesion of the particles that are being compressed. 2. Regulate the pressure carefully. 3. Secure readily soluble or medicinally active tablets. 4.
Prevent adhesion of the material to any part of the machine.
QUALITY CHECK-UP The Tablets are checked for quality. PACKING Then they are packed in suitable plastic packs marketing.
and despatched for
PACKING: 100 Tablets (Weight = 50 gms.) per pack (Each Tablet = 500 mg)
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PROCESS FLOW DIAGRAM FOR THE MANUFACTURE OF AYURVEDIC TABLETS FOR DIABETES Ingredients As per Formulation Grinder
Granulator
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MANUFACTURING PROCESS OF AYURVEDIC CAPSULES FOR DIABETES As per the formulation specified under Deebonil type Ayurvedic capsules recipe. Each capsule of 500 mg contains 1. Abhrak Bhasm
35 mg
% age 7.00
2. Gurmar Buti
50 mg
10.00
3. Haldi Shudh
10 mg
2.00
4. Jamun Seeds
100 mg
20.00
5. Jaiphal
40 mg
8.00
6. Kapit Phal
30 mg
6.00
7. Karela Seeds
50 mg
10.00
8. Makar Dhwaj
35 mg
7.00
9. Parwal Bhasm
35 mg
7.00
10. Shud Shilajit
40 mg
8.00
11. Trivang Bhasm
50 mg
10.00
12. Vijay Sar
25 mg
5.00
---------500 mg ----------
---------100.00 -----------
Bhavina, Karela Ras, Pan Ras, Methi Ras, etc.
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MIXING Out of these, the ingredients viz. Abhrak Bhasm, Gurmar Buti, Haldi shudh, jamun seeds, Jaiphal, kapit phol, Karela seeds, Trivang Bhasm & Vijay sar are in requisite quantities and introduced into a mixer fitted with a double or single spiral agitator and mixed well. MILLING/GRINDING Then the above mixture is subjected to milling operation, which comprises crushing and grinding, crushing is conducted in jaw tooth crusher. Then it is fed to the grinder and the contents are ground well. Then, the remaining ingredients viz. Makar Dhwaj, Pariwal Bhasm & Shud shilajit in requisite quantities are mixed into the above staff and well ground. CAPSULE FILLING The powders or liquid are filled in soft and hard gelatine capsules. Hard filling of capsules has been practiced for a long time in India. But now some semi automatic and automatic machines are being used. The semi automatic machines only fill the bottom of the capsules. The caps however are removed and replaced manually. The complete automatic machines remove the caps and clean the outside of capsules. A semi automatic, hand operated capsules filling machine is capable of opening and closing 200 hard gelatine capsules at a time in a single operation. The unit is mainly fabricated out of steel and brass, chromium, with the all contact parts made of stainless steel. The empty capsules are first loaded in the sockers, provided in the loading keys which are then fed in the machine where the capsules are opened, filled with the powder, pressed bad closed. The powder to be filled is made by mixing the ingredients thoroughly with a suitable diluent. The next step after filling the capsules, this is usually accomplished, with held of a motorized capsules sealing machine. It can seal 30,000 to 40,000 capsules, or more in a day. All contact parts are made of stainless steel with motor, heaters and panel lights. This machine can process all sizes of capsules.
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Soft gelatine capsules are usually employed for filling of liquids, ointments and a modern die, capsules machine, is employed for the purposes. It is a self contained unit capable of continuously and automatically producing finished, capsules from a supply of gelatine mass and filling materials. Two continuous gelatine ribbons formed by the machine, it self are brought into vonveragence between a pair of revolging dies and an injection wedge. Accurate filling under pressure and sealing of the capsule occurs, as dual and coidicent in operations perfectly times against each other. Subsequent sealing the capsules is also achieved by the same machine, this machine also has the advantage that the contents of each capsule are accurately measured or weighes individually by the single store of a pump. The machine contains a back of pump so arranged that many capsules may be formed and filled simultaneously. A provision is also made to encapsulate the products such as vitamin A under an inert atmosphere so as to avoid oxidation of the vitamin. After the process of filling and sealing the capsules are ready for packing and shipments. Specially designed capsules counters for quick and accurate counting of the capsule are available to be used as an laternate to manual counterting, the later being a tedious and time consuming job. However, the mechanical counting, of capsules also provide a means of producing a product completely untouched by hand right from the manufacturing to packaging stage provided the mechanical packaging is employed. A capsule counter is a simple mechanism. A typical counter can count upto 2,00,000 capsules per day. These are available in various sizes. QUALITY CHECKUP There are checked for quality. PACKING Then they are packed in plastic packs and despatched for marketing. PACKING 40 Capsules (500 mg each Capsule) per pack.
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PROCESS FLOW DIAGRAM FOR THE MANUFACTURE OF AYURVEDIC CAPSULES FOR DIABETES
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MANUFACTURING PROCESS OF AYURVEDIC GRANULES FOR DIABETES As per the formulation for Madhukari type granules. Composition:
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MILLING/GRINDING Then the above mixture is subjected to milling operation which comprises crushing and grinding, crushing is conducted in jaw tooth crusher. Then it is fed to the grinder and the contents are ground well. Then, the remaining ingredient shilajeet in requisite quantity is taken and mixed into the above stuf and well ground. GRANULATION Then the above stuff is subjected to granulation in a granulator, where granules are formed. Though the methods of granulation in corporate Dry granulation, moist-granulation, Granulation by preliminary compression, the general method of granulation is to cause it rubbing through a screen or buffer plate having a suitable mesh for producing desired size granules.
In the method of granulation by slugging, the ingredients which are thoroughly in the form of powder, are compressed into crude tablets or slugs. These slugs are ground down to the size of the granules desired. Subsequently these granules are recompressed into the final product. The machine oscillating granulator breaks the slugs into uniform granules. In the oscillating granulator machine has a rotor at the bottom of the hopper which oscillates back and forth, breaking the slugs and forcing them through a special steel screen of proper mesh. QUALITY CHECK-UP After the granules are formed. They are checked for quality. PACKING Then these granules are packed in suitable plastic packs and despatched for marketing.
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PLANT LAYOUT OF AYURVEDIC MEDICINE FOR DIABETES (GRANULES, CAPASULES AND TABLETS)
Raw Material Storage 50 sq. mt.
Tablet Making Section
Capsule Making Section
Granules Making Section
Production Shed 400 sq. mt.
Finished Goods Storage 50 sq. mt.
Adm. Building 50 sq.mt.
vvvvvvvvvvvvvv vvvvvvvvvvvvvv PARKING vvvvvvvvvvvvvv vvvvvvvvvvvvvv vv GATE
Lab. 25 sq.mt.
Security Guard Room 10 sq.mt.
TOTAL LAND AREA = 700 SQ.MT.
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SUPPLIERS OF PLANT AND MACHINERY
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Mixer/Blenders
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Storage Tanks
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Stirrers
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Pulverizers
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Paste Filling Equipments
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Bottle Filling Machine
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SUPPLIERS OF PACKAGING MATERIALS Aluminium Caps
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Pharma Bottles
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Ayurvedic Herbs
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LIQUID AYURVEDIC MEDICINE FOR DIABETES Raw Materials Calculations Basis = 1 Month Plant Capacity = 25 Kgs/day = 625 Kgs/Month Liquid Ayurvedic For Diabetes As per the Formulation of Liquid Ayurvedic medicine Composition
%Content
% age Extract Recovery
(Average Recovery = 1.72%) Considering average recovery = 1.72% 625 Total Raw Materials required/month = 100 x --------- Kg. = 36,337 kgs. 1.72
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1) Gurmar (leaves) reqd.
= 0.45 x 36,337
= 16,351.65 kgs.
2) Vijay Sar (Wood) reqd.
= 0.25 x 36,337
= 9,084.25 kgs.
3) Bilva Patra reqd.
= 0.10 x 36,337
= 3,633.70 kgs.
4) Karela Seeds reqd.
= 0.10 x 36,337
= 3,633.70 kgs.
5) Jamun Guthi reqd.
= 0.10 x 36,337
= 3,633.70 kgs.
RAW MATERIALS CALCULATIONS FOR AYURVEDIC MEDICINES FOR DIABETES (GRANULES, CAPSULES & TABLETS) 1.
AYURVEDIC GRANULES FOR DIABETES (MADHUHARI TYPE) Capacity = 50 kgs/day (500 packs/day) (1 pack = 100 gms) Granules = 1250 kgs/month Ayurvedic Granules for Diabetes (Madhuhari Type)
As per Formulation For Granules (Madhuhari Type)
2.
AYURVEDIC CAPSULES FOR DIABETES (DEEBONIL TYPE)
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Capacity = 25 kgs/day (1250 packs/day) (1 pack = 40 capsules, Each capsule = 500 mg.) = 625 kgs/month Ayurvedic Capsules For Diabetes (Deebonil Type)
As per Formulation For Capsules (Deebonil Type)
1
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3.
AYURVEDIC TABLETS FOR DIABETES (DYBIT-32 TYPE) Capacity = 25 Kgs/Day (500 packs/day) (1 pack wt. = 50 gms. = 100 Tablets, Each Tablet = 500 mg) = 625 Kgs/Month 1. Vang Bhasm
=
0.01 x 625
= 6.25 Kgs
2. Yashad Bhasm
=
0.01 x 625
= 6.25 Kgs
3. Loha Bhasm
= 0.0165 x 625
= 10.31 Kgs
4. Tej Patra
= 0.1365 x 625
= 85.31 Kgs
5. Triphala Churn
=
0.53 x 625 ----------------
= 3.31 Kgs
100 6. Vijay Sar
= 0.0652 x 625
= 40.75 Kgs
7. Saptarangi
= 0.0435 x 625
= 27.19 Kgs
8. Gudmar
= 0.0435 x 625
= 27.19 Kgs
9. Jamun Beej
= 0.0435 x 625
= 27.19 Kgs
10. Tulsi Patra
= 0.0218 x 625
= 27.19 Kgs
11. Bel Patra
= 0.0218 x 625
= 27.19 Kgs
12. Kali Mirch
= 0.0218 x 625
= 27.19 Kgs
13. Aam Beej
= 0.0218 x 625
= 27.19 Kgs
14. Neem Beej
= 0.0218 x 625
= 27.19 Kgs
15. Neem Patra
= 0.0218 x 625
= 27.19 Kgs
16. Kundru
= 0.0218 x 625
= 27.19 Kgs
17. Amla
= 0.0218 x 625
= 27.19 Kgs
18. Haldi
= 0.0218 x 625
= 27.19 Kgs
19. Methi Beej
= 0.0218 x 625
= 27.19 Kgs
20. Gilay
= 0.0218 x 625
= 27.19 Kgs
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21. Patol Patra
= 0.0218 x 625
= 27.19 Kgs
22. Pitta Papdc
= 0.0218 x 625
= 27.19 Kgs
23. Chirayata
= 0.0218 x 625
= 27.19 Kgs
24. Surphonkha
= 0.0218 x 625
= 27.19 Kgs
25. Makoy
= 0.0218 x 625
= 27.19 Kgs
26. Kutki
= 0.0218 x 625
= 27.19 Kgs
27. Kalmegh
= 0.0218 x 625
= 27.19 Kgs
28. Karela
= 0.0218 x 625
= 27.19 Kgs
29. Pokher Mool
= 0.0218 x 625
= 27.19 Kgs
30. Shilajeet
= 0.0218 x 625
= 27.19 Kgs
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A-
1
PLANT ECONOMICS
Rated Plant capacity
= =
100.00 Kgs./day 30000.00 Kgs./annum AYURVEDIC MEDICINES
No. of working days
= =
25 days/month 300 days/annum
No. of shifts
=
One shift
=
Basis
1
per day
8 hours
50 Kgs/Day (500 Packs/Day) Gra nules, 25 Kgs/Day (1250 Packs/ Day) Capsules, 25 Kgs/Day (500 Packs/Day Tablets. Currency - Rs.
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A-
2
LAND & BUILDING
1.
2.
3.
4.
5.
6.
7.
Total land required 700 sq.mts. @ Rs. 5000/-per sq.mtr.
Rs.
35,00,000.00
Production shed 400 sq.mts. @ Rs. 10,000/-per sq.mtr.
Rs.
40,00,000.00
Raw material storage 50 sq.mts. @ Rs. 10,000/-per sq.mtr.
Rs.
5,00,000.00
Finished Goods Storage 50 sq.mts. @ Rs. 10,000/-per sq.mtr.
Rs.
5,00,000.00
Laboratory 25 sq.mts. @ Rs. 12,000/-per sq.mtr.
Rs.
3,00,000.00
Administration Building 50 sq.mts. @ Rs. 12,000/-per sq.mtr.
Rs.
6,00,000.00
Boundary wall, gate, etc
Rs.
3,00,000.00
TOTAL
-----------------------Rs. 97,00,000.00 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A-
3
PLANT & MACHINERY
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A-
4
OTHER FIXED ASSETS
1.
Office equipment, furniture plus other equipment & accessories
Rs.
1,50,000.00
Installation costs for water, electricity, fuel etc.
Rs.
5,00,000.00
3.
Pre-operative & preliminary expenses
Rs.
1,00,000.00
4.
Technical Know-How & consultancy
Rs.
50,000.00
5.
Miscellaneous
Rs.
30,000.00
2.
TOTAL
-----------------------Rs. 8,30,000.00 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A-
5
FIXED CAPITAL 1.
LAND & BUILDING
Rs.
97,00,000.00
2.
PLANT & MACHINERY
Rs.
55,57,000.00
3.
OTHER FIXED ASSETS
Rs.
8,30,000.00
TOTAL
-----------------------Rs. 1,60,87,000.00 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A-
6
WORKING CAPITAL REQUIREMENT/MONTH RAW MATERIALS
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TOTAL
-----------------------Rs. 22,85,316.72 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 11
SALARY & WAGES / MONTH
1.
Manager/Technologist
1 No.
Rs.
35,000.00
2.
Shift Supervisor
1 No.
Rs.
25,000.00
3.
Chemist
1 No.
Rs.
22,000.00
4.
Skilled workers
5 No.
Rs.
60,000.00
5.
Semi skilled workers
6 No.
Rs.
60,000.00
6.
Unskiiled workers
8 No.
Rs.
72,000.00
7.
Marketing personnel
2 No.
Rs.
32,000.00
8.
Accountant
1 No.
Rs.
14,000.00
9.
Typist/Clerk
1 No.
Rs.
10,000.00
10.
B. Pharmacist
1 No.
Rs.
20,000.00
11.
Peon/Chowkidar
2 No.
Rs.
18,000.00
TOTAL
-----------------------Rs. 3,68,000.00 ------------------------
Plus perks @ 33% p.a. Rs. TOTAL
1,21,440.00
-----------------------Rs. 4,89,440.00 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 12
UTILITIES AND OVERHEADS
TOTAL
Total load is
-----------------------Rs. 4,90,500.00 ------------------------
33 Kwatts
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 13
TOTAL WORKING CAPITAL/MONTH 1.
RAW MATERIAL
Rs.
22,85,316.72
2.
SALARY & WAGES
Rs.
4,89,440.00
3.
UTILITIES & OVERHEADS
Rs.
4,90,500.00
TOTAL
1.
WORKING CAPITAL FOR
2 MONTHS
2.
MARGIN MONEY FOR W/C LOAN
-----------------------Rs. 32,65,256.72 -----------------------Rs.
65,30,513.44
Rs.
16,32,628.36
Rs.
1,60,87,000.00
Rs.
16,32,628.36
COST OF PROJECT TOTAL FIXED CAPITAL MARGIN MONEY
TOTAL
-----------------------Rs. 1,77,19,628.36 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 14
TOTAL CAPITAL INVESTMENT
TOTAL FIXED CAPITAL
Rs. 1,60,87,000.00
TOTAL WORKING CAPITAL FOR 2 MONTHS Rs. TOTAL
65,30,513.44
-----------------------Rs. 2,26,17,513.44 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 15
COST OF PRODUCTION/ANNUM
TOTAL
-----------------------Rs. 4,39,97,844.95 ------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 16
TURN OVER/ANNUM
TOTAL
-----------------------Rs. 5,39,25,000.00 ------------------------
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PROFIT
=
RECEIPTS - COST OF PRODUCTION
PROFIT SALES RATIO = =
=
RATE OF RETURN =
Profit / Sales
x
100
99,27,155.05 ------------------------------ X 100 5,39,25,000.00 18.41 %
Operating profit / T.C.I =
=
x
100
99,27,155.05 ------------------------------ X 100 2,26,17,513.44 43.89 %
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 17
BREAK EVEN POINT (B.E.P) Fixed Costs of the plant are as under 1.
Interests
Rs.
30,53,364.31
2.
Depreciation
Rs.
17,61,400.00
3.
40.00% of salaries
Rs.
23,49,312.00
4.
40.00% of overheads TOTAL
B.E.P.
Rs. 23,54,400.00 -----------------------Rs. 95,18,476.31 ------------------------
=
FIXED COSTS ------------------------------ X 100 FIXED COSTS + PROFIT
=
95,18,476.31 ------------------------------ X 100 95,18,476.31 + 99,27,155.05
=
48.95 %
LAND MAN RATIO = Total land / Manpower 700 : 29
::
24 :
1
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
Page A- 18
RESOURCES FOR FINANCE
1. Term loans from Financial institutions ( 65.00 % of fixed capital ) at @13.50% p.a rate of interest
Rs.
1,04,56,550.00
2. Bank loans for 3 months ( 65.00 % of working capital ) at @ 13.50% p.a rate of interest
Rs.
42,44,833.74
3. Self raised capital from even funds & loans from close ones to meet the margin money needs at a @ 13.50% p.a rate of interest
Rs.
79,16,129.70
TOTAL
-------------------------Rs. 2,26,17,513.44 --------------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
INSTALMENT PAYABLE IN
Page A- 19
5 YEARS
================================================================================ Year To Financial To Commercial To others Total institutions banks (Rs. 10456550) (Rs. 4244834) (Rs. 7916130) ================================================================================
================================================================================
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INTEREST PAYABLE IN
5 YEARS
================================================================================ Year On term loans On bank loans On self loans Total (Rs. 10456550) (Rs. 4244834) (Rs. 7916130) @ 13.50 % P.A. @ 13.50 % P.A. @ 13.50 % P.A. ================================================================================
================================================================================
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TOTAL REPAYMENT SCHEDULE FOR 5 YEARS ================================================================================ Year Interest Instalments Total ================================================================================
================================================================================
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
DEPRECIATION CHART FOR
Page A- 20
5 YEARS
================================================================================ Year Building costs Plant & Machinery fur. & office equip. Total ( Rs. 6200000.00 ) ( Rs. 5557000.00 ) ( Rs. 150000.00 ) @ 10.00 % P.A. @ 20.00 % P.A. @ 20.00 % P.A. ================================================================================
================================================================================
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 J.C. 442
PROFIT ANALYSIS FOR
Page A- 21
5 YEARS
================================================================================================ YR CAP. Sales Mfg. Gross DepreInterest Net profit Net profit UTIL Expenses Profit ciation before tax after tax @ 35.00% ================================================================================================
================================================================================================
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CASH FLOW STATEMENT FOR
5 YEARS
================================================================================ YR CAP. Net profit DepreCash Repayment of Net surplus UTIL (after tax) ciation in hand Instalment ================================================================================
================================================================================
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442 PROJECTED BALANCE SHEET FOR ( 5 YEARS)
LIABILITIES
1. 2.
Promoters Capital Term loans
3.
W/C loan
79,16,129 1,04,56,550
Promoters capital Net Surplus Term loans W/C loans
Promoters capital Net Surplus Term loans W/C loans
Promoters capital Net Surplus Term loans W/C loans
70
Year
80
Year
80
Fixed Assets 1,19,07,000 Interest during Construction period @ 13.50 p.a. 11,96,074 Surplus funds 95,14,438 -------------------2,26,17,512 --------------------
% Capacity Depreciated value of Fixed Assets Working Capital Surplus funds
1,01,45,600 45,71,359 73,59,378 -------------------2,20,76,337 --------------------
% Capacity
1,03,15,230 1. 36,52,666 62,73,930 2. 25,46,901 3. -------------------2,27,88,727 -------------------3
1. 2. 3. 4.
Year
79,16,129 1. 23,99,101 83,65,240 2. 33,95,867 3. -------------------2,20,76,337 -------------------2
1. 2. 3. 4.
1. 2.
42,44,833 3. -------------------2,26,17,512 -------------------1
1. 2. 3. 4.
ASSETS
Depreciated value of Fixed Assets Working Capital Surplus funds
86,74,480 52,24,410 88,89,837 -------------------2,27,88,727 --------------------
% Capacity
1,39,67,896 1. 39,66,154 41,82,620 2. 16,97,935 3. -------------------2,38,14,605 --------------------
Depreciated value of Fixed Assets Working Capital Surplus funds
74,41,784 52,24,410 1,11,48,411 -------------------2,38,14,605 --------------------
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AYURVEDIC MEDICINES [EIRI/EDPR/1638] J.C. 442
4 1. 2. 3. 4.
Promoters capital Net Surplus Term loans W/C loans
Promoters capital Net Surplus Term loans W/C loans
90
% Capacity
1,79,34,050 1. 52,52,605 20,91,310 2. 8,48,969 3. -------------------2,61,26,934 -------------------5
1. 2. 3. 4.
Year
Year
100
Depreciated value of Fixed Assets 64,05,408 Working Capital 58,77,462 Surplus funds 1,38,44,064 -------------------2,61,26,934 --------------------
% Capacity
2,31,86,655 1. 65,51,043 0 2. 0 3. -------------------2,97,37,698 --------------------
Depreciated value of Fixed Assets Working Capital Surplus funds
55,31,109 65,30,513 1,76,76,076 -------------------2,97,37,698 --------------------
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We hope MARKET SURVEY CUM DETAILED TECHNO ECONOMIC FEASIBILITY REPORT in your possession at the time, must have conveyed you the elementary idea on process data, market and economics. We feel you must have now taken a decision to finalize your project plan for ultimate implementation in a successful manner. Before you go ahead, we suggest you to take our PRACTICAL PROJECT EXECUTION KNOW HOW REPORT. "EIRI" offer you PRACTICAL PROJECT EXECUTION KNOW HOW REPORT on this project. Brief contents of PRACTICAL PROJECT EXECUTION KNOW HOW REPORT are as under : THIS REPORT SHALL BE FULLY BASE DON CLIENT’S REQUIREMENTS WITH THEIR PROJECT COST, CAPACITY, PROJECT LOCATION WITH DETAILED MARKET SURVEY, DELIVERY SHALL BE MADE WITHIN 20 DAYS ON RECEIPT OF 60% AS ADVANCE- EIRI • • • • • • • • • • • • • • • • • • • • • • •
Introduction Properties BIS (Bureau of Indian Standard) Specifications & Requirements Uses & Applications Present Indian Market Position Expected Future Demand Export & Import Statistics Data Names and Addresses of Existing Units (Present Manufactures) List of Plant & Machineries Miscellaneous Items and Accessories Instruments, Laboratory Equipments and Accessories Electrification, Electric Load and Water Maintenance, Suppliers/Manufacturers of Plant and Machineries Process of Manufacture with formulae if applicable Flow Sheet Diagram List of Raw Materials Availability of Raw Materials Requirement of Staff & Labour Personnel Management Skilled & Unskilled Labour Requirement of Land Area Built up Area Plant Layout.
along with financial details as under: Summary of Capital Cost of Project Land & Side Development Exp. Buildings Plant & Machineries Misc. Fixed Assets Technical Know how Fees & Exp. Preliminary Expenses Pre-operative Expenses Provision for Contingencies below mentioned financial statements (Annexure) will be for 5 to 10 Years
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Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure Annexure
:: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: ::
Cost of Project and Means of Finance Output, Profitability and Cash Flow Chart Assessment of Working Capital requirements Sources of Finance Balance Sheets Break-Even Analysis and profitability analysis. Quantitative Details-Output/Sales/Stocks Sales Realisation Raw Material Cost Other Raw Material Cost Packing Material Cost Consumables, Store etc., Employees Expenses Fuel Expenses Power/Electricity Expenses Repairs & Maintenance Exp. Other Mfg. Expenses Administration Expenses Selling Expenses Depreciation Charges - Profitability Depreciation Charges Interest and Repayment - Term Loans Tax on Profit Assumptions for Profitability workings Assessment of Working Capital
Engineers India Research Institute (EIRI) is a renowned name in the industrial world for offering technical and financial consultancy services. EIRI services are: Detailed Feasibility Reports New Project Identification Project Feasibility and Market Study Identification of Lucrative Industrial Project Opportunities Preparation of Project Profiles / Pre-Investment and Detailed Feasibility Studies, Market Surveys / Studies, Market Survey Cum Detailed Techno-Economic Feasibility Reports Project Reports in CD Roms Identification of Plant /Process/Machinery and Equipment, Industrial General Guidance for setting up new industrial projects. PLEASE SEND YOUR CONFIRMED ORDER WITH REMITTANCE AT: ENGINEERS INDIA RESEARCH INSTITUTE 4449, Nai Sarak, Main Road, Delhi-110 006 (India) Ph: 91-11-23916431, 23918117, 45120361, 64727385, 23947058 E-Mail:
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